Wei-Jan Huang

文章

(-)-Epigallocatechin gallate, the most active polyphenolic catechin in green tea, presynaptically facilitates Ca2+-dependent glutamate release via activation of protein kinase C in rat cerebral cortex

Chou, C. W., Huang, W. J., Tien, L. T. & Wang, S. J., 11月 2007, 於: Synapse. 61, 11, p. 889-902 14 p.

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1,2,3,4,6-Penta-O-galloyl-D-glucose Interrupts the Early Adipocyte Lifecycle and Attenuates Adiposity and Hepatic Steatosis in Mice with Diet-Induced Obesity

Sathyanarayana, A. R., Lu, C. K., Liaw, C. C., Chang, C. C., Han, H. Y., Green, B. D., Huang, W. J., Huang, C., He, W. D., Lee, L. C. & Liu, H. K., 4月 1 2022, 於: International journal of molecular sciences. 23, 7, 4052.

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4 引文斯高帕斯（Scopus）

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats

Lin, T. Y., Huang, W. J., Wu, C. C., Lu, C. W. & Wang, S. J., 2月 10 2014, 於: PLoS One. 9, 2, e88644.

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37 引文斯高帕斯（Scopus）

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., 3月 2020, 於: Food and Function. 11, 3, p. 2328-2338 11 p.

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9 引文斯高帕斯（Scopus）

Activation of iodosobenzene by catalytic tetrabutylammonium iodide and its application in the oxidation of some isoquinoline alkaloids

Huang, W. J., Singh, O. V., Chen, C. H., Chiou, S. Y. & Lee, S. S., 2002, 於: Helvetica Chimica Acta. 85, 4, p. 1069-1078 10 p.

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34 引文斯高帕斯（Scopus）

A facile method for the synthesis of glaucine and norglaucine from boldine

Huang, W. J., Chen, C. H., Singh, O. V., Lee, S. L. & Lee, S. S., 2002, 於: Synthetic Communications. 32, 23, p. 3681-3686 6 p.

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23 引文斯高帕斯（Scopus）

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 5月 15 2017, 於: International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

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20 引文斯高帕斯（Scopus）

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 4月 28 2014, 於: Cancer Letters. 346, 1, p. 84-93 10 p.

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20 引文斯高帕斯（Scopus）

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., 4月 15 2016, 於: Life Sciences. 151, p. 7-14 8 p.

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29 引文斯高帕斯（Scopus）

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., 11月 1 2019, 於: Cancers. 11, 11, 1703.

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13 引文斯高帕斯（Scopus）

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 8月 1 2017, 於: Cancer Letters. 400, p. 79-88 10 p.

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19 引文斯高帕斯（Scopus）

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., 3月 1 2018, 於: Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

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2 引文斯高帕斯（Scopus）

A novel hydroxysuberamide derivative potentiates MG132-mediated anticancer activity against human hormone refractory prostate cancers - The role of histone deacetylase and endoplasmic reticulum stress

Chen, Y. C., Huang, W. J., Hsu, J. L., Yu, C. C., Wang, W. T. & Guh, J. H., 9月 2013, 於: Prostate. 73, 12, p. 1270-1280 11 p.

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6 引文斯高帕斯（Scopus）

A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase i

Yu, C. C., Pan, S. L., Chao, S. W., Liu, S. P., Hsu, J. L., Yang, Y. C., Li, T. K., Huang, W. J. & Guh, J. H., 8月 1 2014, 於: Biochemical Pharmacology. 90, 3, p. 320-330 11 p.

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27 引文斯高帕斯（Scopus）

Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats

Huang, W. J., Niu, H. S., Lin, M. H., Cheng, J. T. & Hsu, F-L., 6月 25 2010, 於: Journal of Natural Products. 73, 6, p. 1170-1172 3 p.

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62 引文斯高帕斯（Scopus）

A Taiwanese propolis derivative induces apoptosis through inducing endoplasmic reticular stress and activating transcription factor-3 in human hepatoma cells

Suk, F. M., Lien, G. S., Huang, W. J., Chen, C. N., Lu, S. Y., Yang, Y. C., Yan, M. D. & Liang, Y. C., 2013, 於: Evidence-based Complementary and Alternative Medicine. 2013, 658370.

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5 引文斯高帕斯（Scopus）

Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia

Chen, L. C., Huang, H. L., Huangfu, W. C., Yen, S. C., Ngo, S. T., Wu, Y. W., Lin, T. E., Sung, T. Y., Lien, S. T., Tseng, H. J., Pan, S. L., Huang, W. J. & Hsu, K. C., 10月 23 2020, 於: Journal of Natural Products. 83, 10, p. 2967-2975 9 p.

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12 引文斯高帕斯（Scopus）

Butyrate modulates adipose-derived stem cells isolated from polygenic obese and diabetic mice to drive enhanced immunosuppression

Hsu, W. T., Huang, W. J., Chiang, B. L. & Tseng, P. H., 7月 2021, 於: Cytotherapy. 23, 7, p. 567-581 15 p.

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2 引文斯高帕斯（Scopus）

Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes

Lin, L. C., Ho, F. M., Yen, S. J., Wu, P. Y., Hung, L. F., Huang, W. J. & Liang, Y. C., 12月 2010, 於: International Immunopharmacology. 10, 12, p. 1520-1525 6 p.

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13 引文斯高帕斯（Scopus）

Cerebellar α6-subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

Chiou, L-C., Lee, H-J., Ernst, M., Huang, W-J., Chou, J-F., Chen, H-L., Mouri, A., Chen, L-C., Treven, M., Mamiya, T., Fan, P-C., Knutson, D. E., Witzigmann, C., Cook, J., Sieghart, W. & Nabeshima, T., 2018, 於: British Journal of Pharmacology. 175, 12, p. 2414-2427 14 p.

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21 引文斯高帕斯（Scopus）

Chalcones display anti-nlrp3 inflammasome activity in macrophages through inhibition of both priming and activation steps—structure-activity-relationship and mechanism studies

Leu, W. J., Chu, J. C., Hsu, J. L., Du, C. M., Jiang, Y. H., Hsu, L. C., Huang, W. J. & Guh, J. H., 12月 2020, 於: Molecules. 25, 24, 5960.

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6 引文斯高帕斯（Scopus）

Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan

Chen, C. Y., Chiu, F. Y., Lin, Y., Huang, W. J., Hsieh, P. S. & Hsu, F-L., 1月 22 2015, 於: International journal of molecular sciences. 16, 2, p. 2497-2516 20 p.

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12 引文斯高帕斯（Scopus）

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Chen, C. N., Hsiao, C. J., Lee, S. S., Guh, J. H., Chiang, P. C., Huang, C. C. & Huang, W. J., 1月 1 2012, 於: Natural Product Research. 26, 2, p. 116-124 9 p.

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24 引文斯高帕斯（Scopus）

Clerodendrum inerme leaf extract alleviates animal behaviors, hyperlocomotion, and prepulse inhibition disruptions, mimicking tourette syndrome and schizophrenia

Chen, H. L., Lee, H. J., Huang, W. J., Chou, J. F., Fan, P. C., Du, J. C., Ku, Y. L. & Chiou, L. C., 2012, 於: Evidence-based Complementary and Alternative Medicine. 2012, 284301.

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19 引文斯高帕斯（Scopus）

Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Ho, S. Y., Lin, P. & Wang, Y. J., 6月 10 2016, 於: Molecular Cancer. 15, 1, 46.

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34 引文斯高帕斯（Scopus）

Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors

Hsu, J. Y., Hsu, K. C., Sun, C., Chou, C. H., Lin, T. E., Sung, T. Y., Tseng, H. J., Yen, S. C., Yang, C. R. & Huang, W. J., 3月 2023, 於: Biomedicine and Pharmacotherapy. 159, 114258.

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1 引文斯高帕斯（Scopus）

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., 7月 3 2018, 於: Frontiers in Pharmacology. 9, JUL, 708.

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4 引文斯高帕斯（Scopus）

Development of a simple fluorescence sensing system for carbonyl stress in urine

Huang, W. J., Sun, Y. T., Lee, W. H., Lin, P. Y. & Chen, C. M., 2021, 於: Sensors and Materials. 33, 10, p. 3489-3497 9 p.

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Dibenzofuran, 4-chromanone, acetophenone, and dithiecine derivatives: Cytotoxic constituents from eupatorium fortunei

Chang, C. H., Wu, S., Hsu, K. C., Huang, W. J. & Chen, J. J., 7月 2021, 於: International journal of molecular sciences. 22, 14, 7448.

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3 引文斯高帕斯（Scopus）

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., 1月 1 2018, 於: European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

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16 引文斯高帕斯（Scopus）

Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment

Lin, T. E., Yang, C. R., Chou, C. H., Hsu, J. Y., Chao, M. W., Sung, T. Y., Hsieh, J. H., Huang, W. J. & Hsu, K. C., 2月 2022, 於: Biomedicine and Pharmacotherapy. 146, 112459.

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4 引文斯高帕斯（Scopus）

DUSP1 expression induced by HDAC1 inhibition mediates gefitinib sensitivity in non-small cell lung cancers

Lin, Y. C., Lin, Y. C., Shih, J. Y., Huang, W. J., Chao, S. W., Chang, Y. L. & Chen, C. C., 1月 15 2015, 於: Clinical Cancer Research. 21, 2, p. 428-438 11 p.

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33 引文斯高帕斯（Scopus）

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., 6月 15 2012, 於: Food Chemistry. 132, 4, p. 2074-2080 7 p.

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28 引文斯高帕斯（Scopus）

Effects of yam tuber protein, dioscorin, on attenuating oxidative status and learning dysfunction in d-galactose-induced BALB/c mice

Han, C. H., Lin, Y. F., Lin, Y. S., Lee, T. L., Huang, W. J., Lin, S. Y. & Hou, W. C., 3月 2014, 於: Food and Chemical Toxicology. 65, p. 356-363 8 p.

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29 引文斯高帕斯（Scopus）

Evaluation of antioxidant and free radical scavenging capacities of polyphenolics from pods of caesalpinia pulcherrima

Hsu, F-L., Huang, W. J., Wu, T. H., Lee, M. H., Chen, L. C., Lu, H. J., Hou, W. C. & Lin, M. H., 5月 2012, 於: International Journal of Molecular Sciences. 13, 5, p. 6073-6088 16 p.

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36 引文斯高帕斯（Scopus）

Evaluation of the antihyperuricemic activity of phytochemicals from Davallia formosana by enzyme assay and hyperuricemic mice model

Chen, C. Y., Huang, C. C., Tsai, K. C., Huang, W. J., Huang, W. C., Hsu, Y. C. & Hsu, F-L., 2014, 於: Evidence-based Complementary and Alternative Medicine. 2014, 873607.

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13 引文斯高帕斯（Scopus）

Evaluation of the potential hypoglycemic and beta-cell protective constituents isolated from corni fructus to tackle insulin-dependent diabetes mellitus

Lin, M. H., Liu, H. K., Huang, W. J., Huang, C. C., Wu, T. H. & Hsu, F-L., 7月 27 2011, 於: Journal of Agricultural and Food Chemistry. 59, 14, p. 7743-7751 9 p.

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65 引文斯高帕斯（Scopus）

Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes)

Chang, Y., Huang, W. J., Tien, L. T. & Wang, S. J., 1月 6 2008, 於: European Journal of Pharmacology. 578, 1, p. 28-36 9 p.

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35 引文斯高帕斯（Scopus）

Growth stimulating effect on queen bee larvae of histone deacetylase inhibitors

Huang, C. Y., Chi, L. L., Huang, W. J., Chen, Y. W., Chen, W. J., Kuo, Y. C., Yuan, C. M. & Chen, C. N., 6月 20 2012, 於: Journal of Agricultural and Food Chemistry. 60, 24, p. 6139-6149 11 p.

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20 引文斯高帕斯（Scopus）

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

Qi, J., Singh, S., Hua, W. K., Cai, Q., Chao, S. W., Li, L., Liu, H., Ho, Y., McDonald, T., Lin, A., Marcucci, G., Bhatia, R., Huang, W. J., Chang, C. I. & Kuo, Y. H., 11月 5 2015, 於: Cell Stem Cell. 17, 5, p. 597-610 14 p.

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69 引文斯高帕斯（Scopus）

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., 1月 2 2019, 於: International Journal of Molecular Sciences. 20, 2, p. 410 410.

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16 引文斯高帕斯（Scopus）

Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice

Huang, W. J., Lee, H. J., Chen, H. L., Fan, P. C., Ku, Y. L. & Chiou, L. C., 5月 26 2015, 於: Journal of Ethnopharmacology. 166, p. 18-22 5 p.

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26 引文斯高帕斯（Scopus）

Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABA_A receptors in the cerebellum

Liao, Y. H., Lee, H. J., Huang, W. J., Fan, P. C. & Chiou, L. C., 9月 1 2016, 於: Psychopharmacology. 233, 17, p. 3187-3199 13 p.

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17 引文斯高帕斯（Scopus）

Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice

Mouri, A., Lee, H. J., Mamiya, T., Aoyama, Y., Matsumoto, Y., Kubota, H., Huang, W. J., Chiou, L. C. & Nabeshima, T., 7月 2020, 於: British Journal of Pharmacology. 177, 14, p. 3210-3224 15 p.

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9 引文斯高帕斯（Scopus）

Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach

Yen, S. C., Chen, L. C., Huang, H. L., HuangFu, W. C., Chen, Y. Y., Eight Lin, T., Lien, S. T., Tseng, H. J., Sung, T. Y., Hsieh, J. H., Huang, W. J., Pan, S. L. & Hsu, K. C., 4月 2022, 於: Bioorganic Chemistry. 121, p. 105675 105675.

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6 引文斯高帕斯（Scopus）

Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

Chao, M. W., Lin, T. E., HuangFu, W. C., Chang, C. D., Tu, H. J., Chen, L. C., Yen, S. C., Sung, T. Y., Huang, W. J., Yang, C. R., Pan, S. L. & Hsu, K. C., 12月 2021, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 98-108 11 p.

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6 引文斯高帕斯（Scopus）

Identification of trans, trans-2,4-Decadienal metabolites in mouse and human cells using liquid chromatography-mass spectrometry

Pan, K. L., Huang, W. J., Hsu, M. H., Lee, H. L., Liu, H. J., Cheng, C. W., Tsai, M. H., Shen, M. Y. & Lin, P., 10月 20 2014, 於: Chemical Research in Toxicology. 27, 10, p. 1707-1719 13 p.

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8 引文斯高帕斯（Scopus）

Improved enamine-type addition of dehydroaporphine using microwave irradiation

Huang, W. J., Huang, C. C., Hsin, L. W., Tsai, Y. M., Lin, C. T., Lin, J. H. & Lee, S. S., 6月 9 2010, 於: Tetrahedron Letters. 51, 23, p. 3062-3064 3 p.

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2 引文斯高帕斯（Scopus）

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies

Mahindroo, N., Wang, C. C., Liao, C. C., Huang, C. F., Lu, I. L., Lien, T. W., Peng, Y. H., Huang, W. J., Lin, Y. T., Hsu, M. C., Lin, C. H., Tsai, C. H., Hsu, J. T. A., Chen, X., Lyu, P. C., Chao, Y. S., Wu, S. Y. & Hsieh, H. P., 2月 9 2006, 於: Journal of Medicinal Chemistry. 49, 3, p. 1212-1216 5 p.

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71 引文斯高帕斯（Scopus）

Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor

Chiu, C. F., Chin, H. K., Huang, W. J., Bai, L. Y., Huang, H. Y. & Weng, J. R., 12月 4 2019, 於: Biomolecules. 9, 12, 824.

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19 引文斯高帕斯（Scopus）

黃 偉展

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黃偉展