許 銘仁

研究成果

每年研究成果 2000 2004 2006 2007 2009 2010 2011 2012 2013 2014 2015 2016 2018 2022

• 62 文章
• 4 論文
• 2 海报
• 1 回顧型文獻

每年研究成果

每年研究成果

搜尋結果

• 2022

  Anti-Angiogenetic and Anti-Lymphangiogenic Effects of a Novel 2-Aminobenzimidazole Derivative, MFB

  Hsu, M. J., Chen, H. K., Chen, C. Y., Lien, J. C., Gao, J. Y., Huang, Y. H., Hsu, J. B. K., Lee, G. A. & Huang, S. W., 6月 20 2022, 於: Frontiers in Oncology. 12, 862326.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Vascular Endothelial Growth Factor A 42%
  • Endothelial Cells 30%
  • Benzimidazoles 26%
  • Vascular Endothelial Growth Factor C 22%
  • Lymphangiogenesis 22%
  1 引文 斯高帕斯（Scopus）

• Suppressing VEGF-A/VEGFR-2 Signaling Contributes to the Anti-Angiogenic Effects of PPE8, a Novel Naphthoquinone-Based Compound

  Hsu, M. J., Chen, H. K., Lien, J. C., Huang, Y. H. & Huang, S. W., 7月 1 2022, 於: Cells. 11, 13, 2114.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Naphthoquinones 100%
  • Antiangiogenic 87%
  • Naphthoquinone 80%
  • Vascular Endothelial Growth Factor Receptor 77%
  • Vascular Endothelial Growth Factor A 55%
  2 引文 斯高帕斯（Scopus）
• 2020

  Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade

  Huang, S. W., Chyuan, I. T., Shiue, C., Yu, M. C., Hsu, Y. F. & Hsu, M. J., 1月 1 2020, 於: Journal of Cellular and Molecular Medicine. 24, 2, p. 1822-1836 15 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • AMP-activated protein kinase kinase 100%
  • Lovastatin 88%
  • Survivin 79%
  • MCF-7 Cells 71%
  • p38 Mitogen-Activated Protein Kinases 68%
  32 引文 斯高帕斯（Scopus）
• 2019

  A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti-angiogenesis effects by targeting VEGFR-2 signalling

  Lien, J. C., Chung, C. L., Huang, T. F., Chang, T. C., Chen, K. C., Gao, G. Y., Hsu, M. J. & Huang, S. W., 10月 1 2019, 於: British Journal of Pharmacology. 176, 20, p. 4034-4049 16 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • compound 17 81%
  • Vascular Endothelial Growth Factor Receptor-2 61%
  • Angiogenesis Inhibitors 59%
  • Vascular Endothelial Growth Factor A 42%
  • benzimidazole 35%
  11 引文 斯高帕斯（Scopus）

• WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade

  Huang, S. W., Yang, H. Y., Huang, W. J., Chen, W. C., Yu, M. C., Wang, S. W., Hsu, Y. F. & Hsu, M. J., 11月 6 2019, 於: Frontiers in Oncology. 9, 1188.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • WMJ-S-001 100%
  • Lymphangiogenesis 56%
  • Survivin 49%
  • Endothelial Cells 13%
  • p38 Mitogen-Activated Protein Kinases 6%
  1 引文 斯高帕斯（Scopus）
• 2018

  Abeta-induced cerebral endothelial cell death via LKB1-AMPK-p38MAPK cascade

  Chuang, Y-F. & Hsu, M-J., 2018, 於: Proceedings for Annual Meeting of The Japanese Pharmacological Society. WCP2018, p. PO1-1-60

  研究成果: 雜誌貢獻 › 文章 › 同行評審

• A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

  Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., 3月 1 2018, 於: Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • AMP-activated protein kinase kinase 100%
  • Survivin 79%
  • Squamous Cell Carcinoma of Head and Neck 73%
  • p38 Mitogen-Activated Protein Kinases 68%
  • Cell Death 50%
  2 引文 斯高帕斯（Scopus）

• CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

  Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., 2月 2018, 於: Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Protein Phosphatase 2 100%
  • Ceramides 91%
  • Nitric Oxide Synthase Type II 81%
  • Polysaccharides 72%
  • RAW 264.7 Cells 67%
  17 引文 斯高帕斯（Scopus）
• 2017

  Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition

  Chang, Y., Li, J. Y., Jayakumar, T., Hung, S. H., Lee, W. C., Manubolu, M., Sheu, J. R. & Hsu, M. J., 12月 1 2017, 於: International Journal of Molecular Sciences. 18, 12, 2545.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Enzyme inhibition 100%
  • Phosphatases 94%
  • Cell proliferation 83%
  • phosphatases 83%
  • Ketamine 81%
  10 引文 斯高帕斯（Scopus）

• WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade

  Chuang, Y. F., Huang, S. W., Hsu, Y. F., Yu, M. C., Ou, G., Huang, W. J. & Hsu, M. J., 2017, 於: British Journal of Pharmacology. 174, 17, p. 2941-2961 21 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • WMJ-8-B 100%
  • Survivin 46%
  • Cell Death 29%
  • Breast Neoplasms 24%
  • Histone Deacetylase Inhibitors 11%
  15 引文 斯高帕斯（Scopus）
• 2016

  Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats

  Yen, T. L., Chen, R-J., Jayakumar, T., Lu, W. J., Hsieh, C., Hsu, M-J., Yang, C. H., Chang, C. C., Lin, Y-K., Lin, K. H. & Sheu, J-R., 4月 1 2016, 於: Translational Research. 170, p. 57-72 16 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • andrographolide 100%
  • Andrographolide 99%
  • Cytoprotection 75%
  • Heme Oxygenase-1 74%
  • stroke 73%
  59 引文 斯高帕斯（Scopus）

• Interleukin-6 induces vascular endothelial growth factor-C expression via Src-FAK-STAT3 signaling in lymphatic endothelial cells

  Huang, Y. H., Yang, H. Y., Huang, S. W., Ou, G., Hsu, Y. F. & Hsu, M. J., 7月 1 2016, 於: PLoS One. 11, 7, e0158839.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • vascular endothelial growth factor C 100%
  • non-specific protein-tyrosine kinase 80%
  • Vascular Endothelial Growth Factor C 71%
  • Silencing RNA 67%
  • Phosphotransferase Inhibitor 66%
  40 引文 斯高帕斯（Scopus）

• Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade

  Yen, C. S., Chen, J. C., Chang, Y. F., Hsu, Y. F., Chiu, P. T., Shiue, C., Chuang, Y. F., Ou, G. & Hsu, M. J., 4月 28 2016, 於: Scientific Reports. 6, 25082.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Lovastatin 100%
  • Survivin 89%
  • AMP-Activated Protein Kinases 89%
  • Cell Death 56%
  • Carcinoma 49%
  20 引文 斯高帕斯（Scopus）

• Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species

  Lin, R. K., Lin, Y. F., Hsu, M. J., Hsieh, C. L., Wang, C. Y., Huang, C. C. & Huang, W. J., 2016, 於: Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5528-5533 6 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Lovastatin 100%
  • Reactive Oxygen Metabolite 70%
  • Reactive Oxygen Species 60%
  • PC-3 Cells 30%
  • Cisplatin 27%
  3 引文 斯高帕斯（Scopus）
• 2015

  Antiproliferative activity of hinokitiol, a tropolone derivative, is mediated via the inductions of p-JNK and p-PLCγ1 signaling in PDGF-BB-Stimulated vascular smooth muscle cells

  Yang, P. S., Wang, M. J., Jayakumar, T., Chou, D. S., Ko, C. Y., Hsu, M. J. & Hsieh, C. Y., 5月 1 2015, 於: Molecules. 20, 5, p. 8198-8212 15 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • beta-thujaplicin 100%
  • Tropolone 93%
  • smooth muscle 76%
  • muscle cells 72%
  • Becaplermin 70%
  14 引文 斯高帕斯（Scopus）

• Protein phosphatase 2A in lipopolysaccharide-induced cyclooxygenase-2 expression in murine lymphatic endothelial cells

  Chuang, Y. F., Chen, M. C., Huang, S. W., Hsu, Y. F., Ou, G., Tsai, Y. J. & Hsu, M. J., 8月 28 2015, 於: PLoS ONE. 10, 8, e0137177.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • phosphoprotein phosphatase 100%
  • Protein Phosphatase 2 99%
  • prostaglandin synthase 84%
  • Cyclooxygenase 2 80%
  • endothelial cells 78%
  7 引文 斯高帕斯（Scopus）

• The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death

  Huang, Y. H., Huang, S. W., Hsu, Y. F., Ou, G., Huang, W. J. & Hsu, M. J., 10月 29 2015, 於: Scientific Reports. 5, 15900.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • WMJ-S-001 100%
  • Colorectal Neoplasms 33%
  • Cell Death 31%
  • AMP-Activated Protein Kinases 19%
  • HCT116 Cells 16%
  7 引文 斯高帕斯（Scopus）

• WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domaincontaining protein tyrosine phosphatase 1

  Chang, Y. F., Hsu, Y. F., Chiu, P. T., Huang, W. J., Huang, S. W., Ou, G., Sheu, J. R. & Hsu, M. J., 2015, 於: Oncotarget. 6, 1, p. 85-100 16 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • WMJ-S-001 100%
  • Protein Phosphatase 1 56%
  • Protein Tyrosine Phosphatases 51%
  • Vascular Endothelial Growth Factor A 11%
  • Phosphorylation 9%
  11 引文 斯高帕斯（Scopus）

• WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in LPS-stimulated RAW264.7 macrophages

  Chen, W. C., Yen, C. S., Huang, W. J., Hsu, Y. F., Ou, G. & Hsu, M. J., 2015, 於: British Journal of Pharmacology. 172, 7, p. 1894-1908 15 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • WMJ-S-001 100%
  • Dual Specificity Phosphatase 1 63%
  • CCAAT-Enhancer-Binding Proteins 32%
  • Anti-Inflammatory Agents 30%
  • Macrophages 29%
  23 引文 斯高帕斯（Scopus）
• 2014

  Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

  Chen, Y. Y., Hsieh, C. Y., Jayakumar, T., Lin, K. H., Chou, D. S., Lu, W-J., Hsu, M. J. & Sheu, J. R., 7月 10 2014, 於: Scientific Reports. 4, 5651.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Non-Receptor Type 6 Protein Tyrosine Phosphatase 100%
  • andrographolide 99%
  • Protein Phosphatase 2 82%
  • p38 Mitogen-Activated Protein Kinases 65%
  • Vascular Smooth Muscle 62%
  29 引文 斯高帕斯（Scopus）

• Andrographolide inhibits nuclear factor- B activation through JNK-Akt-p65 signaling cascade in tumor necrosis factor- α -Stimulated vascular smooth muscle cells

  Chen, Y. Y., Hsu, M. J., Hsieh, C. Y., Lee, L. W., Chen, Z. C. & Sheu, J. R., 2014, 於: Scientific World Journal. 2014, 10 p., 130381.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • andrographolide 100%
  • Andrographolide 99%
  • necrosis 80%
  • JNK Mitogen-Activated Protein Kinases 71%
  • LY294002 70%
  21 引文 斯高帕斯（Scopus）

• PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells

  Hsieh, C. Y., Hsiao, G., Hsu, M. J., Wang, Y. H. & Sheu, J. R., 2014, 於: Journal of Cellular and Molecular Medicine. 18, 7, p. 1278-1289 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Tocopherols 100%
  • Protein Phosphatase 2 98%
  • Vascular Smooth Muscle 74%
  • Smooth Muscle Myocytes 66%
  • Interferons 59%
  11 引文 斯高帕斯（Scopus）

• Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells

  Huang, Y. H., Yang, H-Y., Hsu, Y. F., Chiu, P. T., Ou, G. & Hsu, M-J., 4月 1 2014, 於: Angiogenesis. 17, 2, p. 407-418 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Vascular Endothelial Growth Factor C 100%
  • Interleukin-6 56%
  • Endothelial Cells 54%
  • PP2 43%
  • Lymphangiogenesis 29%
  33 引文 斯高帕斯（Scopus）

• Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells

  Chuang, Y. F., Yang, H. Y., Ko, T. L., Hsu, Y. F., Sheu, J. R., Ou, G. & Hsu, M. J., 4月 1 2014, 於: Biochemical Pharmacology. 88, 3, p. 372-383 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Mitogen-Activated Protein Kinase Phosphatases 100%
  • Dual Specificity Phosphatase 1 98%
  • Valproic Acid 94%
  • Cyclooxygenase 2 68%
  • Lipopolysaccharides 55%
  40 引文 斯高帕斯（Scopus）
• 2013

  Andrographolide, a novel NF- B inhibitor, induces vascular smooth muscle cell apoptosis via a ceramide-p47phox-ROS signaling cascade

  Chen, Y. Y., Hsu, M. J., Sheu, J. R., Lee, L. W. & Hsieh, C. Y., 2013, 於: Evidence-based Complementary and Alternative Medicine. 2013, 821813.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • andrographolide 100%
  • Ceramides 75%
  • Vascular Smooth Muscle 62%
  • Smooth Muscle Myocytes 56%
  • Reactive Oxygen Species 51%
  29 引文 斯高帕斯（Scopus）

• Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: Targeting vascular endothelial growth factor receptor signaling and angiogenesis

  Yang, H. Y., Hsu, Y. F., Chiu, P. T., Ho, S. J., Wang, C. H., Chi, H. N., Huang, Y. H., Lee, C. F., Li, Y. S., Ou, G. & Hsu, M. J., 11月 27 2013, 於: PLoS One. 8, 11, e81592.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Osthole 100%
  • vascular endothelial growth factor receptors 98%
  • osthol 96%
  • angiogenesis 70%
  • Vascular Endothelial Growth Factor Receptor 69%
  16 引文 斯高帕斯（Scopus）

• Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade

  Weng, H. Y., Hsu, M. J., Chen, C. C., Chen, B. C., Hong, C. Y., Teng, C. M., Pan, S. L., Chiu, W. T. & Lin, C. H., 1月 5 2013, 於: European Journal of Pharmacology. 698, 1-3, p. 103-109 7 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • denbinobin 100%
  • Rhabdomyosarcoma 54%
  • Glioblastoma 45%
  • Apoptosis 28%
  • Phosphorylation 9%
  11 引文 斯高帕斯（Scopus）

• Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

  Chang, H. L., Chen, C. Y., Hsu, Y. F., Kuo, W. S., Ou, G., Chiu, P. T., Huang, Y. H. & Hsu, M. J., 2013, 於: Biochimica et Biophysica Acta - General Subjects. 1830, 8, p. 4053-4064 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Simvastatin 100%
  • Survivin 81%
  • p38 Mitogen-Activated Protein Kinases 70%
  • Colorectal Neoplasms 54%
  • Apoptosis 41%
  53 引文 斯高帕斯（Scopus）

• Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/ JAK2/STAT3 pathway

  Bai, K. J., Chen, B. C., Pai, H. C., Weng, C. M., Yu, C. C., Hsu, M. J., Yu, M. C., Ma, H. P., Wu, C. H., Hong, C. Y., Kuo, M. L. & Lin, C. H., 1月 2013, 於: Journal of Leukocyte Biology. 93, 1, p. 101-112 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Thrombin 100%
  • Fibroblasts 74%
  • Lung 54%
  • alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 27%
  • Phosphorylation 25%
  21 引文 斯高帕斯（Scopus）
• 2012

  Antihyperglycemic and antioxidant effects of a flavanone, naringenin, in streptozotocin-nicotinamide-induced experimental diabetic rats

  Annadurai, T., Muralidharan, A. R., Joseph, T., Hsu, M. J., Thomas, P. A. & Geraldine, P., 9月 2012, 於: Journal of Physiology and Biochemistry. 68, 3, p. 307-318 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • flavanone 100%
  • naringenin 93%
  • Flavanone 88%
  • Naringenin 87%
  • Niacinamide 79%
  101 引文 斯高帕斯（Scopus）

• Histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide attenuates plasminogen activator inhibitor-1 expression in human pleural mesothelial cells

  Chung, C. L., Sheu, J. R., Chen, W. L., Chou, Y. C., Hsiao, C. J., Hsiao, S. H., Hsu, M. J., Cheng, Y. W. & Hsiao, G., 4月 2012, 於: American Journal of Respiratory Cell and Molecular Biology. 46, 4, p. 437-445 9 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Histone Deacetylase Inhibitors 100%
  • Plasminogen Activator Inhibitor 1 96%
  • Histone 91%
  • Acids 64%
  • Transforming Growth Factors 48%
  10 引文 斯高帕斯（Scopus）

• Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: Regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade

  Lu, W-J., Lin, K. H., Hsu, M. J., Chou, D. S., Hsiao, G. & Sheu, J. R., 10月 1 2012, 於: Biochemical Pharmacology. 84, 7, p. 914-924 11 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • andrographolide 100%
  • Andrographolide 99%
  • Hydroxyl Radical 70%
  • p38 Mitogen-Activated Protein Kinases 65%
  • Blood Platelets 49%
  61 引文 斯高帕斯（Scopus）

• Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway

  Ko, W. C., Chen, B. C., Hsu, M. J., Tsai, C. T., Hong, C. Y. & Lin, C. H., 1月 2012, 於: Acta Pharmacologica Sinica. 33, 1, p. 49-56 8 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • PAR-1 Receptor 100%
  • Connective Tissue Growth Factor 92%
  • JNK Mitogen-Activated Protein Kinases 78%
  • Transcription Factor AP-1 77%
  • Thrombin 69%
  13 引文 斯高帕斯（Scopus）

• Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells

  Hsu, Y. F., Sheu, J. R., Lin, C-H., Yang, D. S., Hsiao, G., Ou, G., Chiu, P. T., Huang, Y. H., Kuo, W. H. & Hsu, M. J., 2月 2012, 於: Biochimica et Biophysica Acta - General Subjects. 1820, 2, p. 104-115 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Sirtinol 100%
  • Trichostatin A 85%
  • sirtinol 84%
  • trichostatin A 64%
  • Survivin 58%
  46 引文 斯高帕斯（Scopus）

• Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells

  Weng, H. Y., Hsu, M. J., Wang, C. C., Chen, B. C., Hong, C. Y., Chen, M. C., Chiu, W. T. & Lin, C. H., 2012, 於: Journal of Biomedical Science. 19, 1, 86.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • zerumbone 100%
  • Zerumbone 99%
  • Apoptosis 34%
  • Transfection 20%
  • Phosphorylation 19%
  36 引文 斯高帕斯（Scopus）
• 2011

  Andrographolide enhances nuclear factor-κB subunit p65 Ser ⁵³⁶ dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells

  Hsieh, C. Y., Hsu, M. J., Hsiao, G., Wang, Y. H., Huang, C. W., Chen, S. W., Jayakumar, T., Chiu, P. T., Chiu, Y. H. & Sheu, J. R., 2月 25 2011, 於: Journal of Biological Chemistry. 286, 8, p. 5942-5955 14 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • andrographolide 100%
  • Andrographolide 99%
  • Protein Phosphatase 2 82%
  • Dephosphorylation 79%
  • Vascular Smooth Muscle 62%
  71 引文 斯高帕斯（Scopus）

• MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide

  Hsu, Y. F., Sheu, J. R., Lin, C-H., Chen, W. C., Hsiao, G., Ou, G., Chiu, P. T. & Hsu, M. J., 12月 2011, 於: Biochimica et Biophysica Acta - General Subjects. 1810, 12, p. 1160-1169 10 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Trichostatin A 100%
  • Dual Specificity Phosphatase 1 85%
  • trichostatin A 75%
  • Umbilicus 62%
  • Lipopolysaccharide 62%
  17 引文 斯高帕斯（Scopus）

• Molecular mechanisms in lipopolysaccharide-induced interleukin 6 release in lymphatic endothelial cells

  Hsu, W. H., Yang, H. Y., Chiu, P. T. & Hsu, M. J., 9月 2011, 於: Journal of Food and Drug Analysis. 19, 3

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • interleukin-6 100%
  • mitogen-activated protein kinase 98%
  • endothelial cells 92%
  • lipopolysaccharides 86%
  • Lipopolysaccharides 77%
  1 引文 斯高帕斯（Scopus）

• Molecular mechanisms in peptidoglycan-induced human umbilical vascular endothelial cell apoptosis

  Jang, T. N., Chiu, P. T., Chen, W. C. & Hsu, M. J., 6月 2011, 於: Journal of Food and Drug Analysis. 19, 2

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • umbilicus 100%
  • Peptidoglycan 90%
  • peptidoglycans 83%
  • Umbilicus 83%
  • MAP Kinase Kinase Kinase 5 79%

• p53 in trichostatin A induced C6 glioma cell death

  Hsu, Y. F., Sheu, J. R., Hsiao, G., Lin, C-H., Chang, T. H., Chiu, P. T., Wang, C. Y. & Hsu, M. J., 5月 2011, 於: Biochimica et Biophysica Acta - General Subjects. 1810, 5, p. 504-513 10 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Trichostatin A 100%
  • trichostatin A 75%
  • Cell Death 60%
  • Trichostatin 56%
  • Glioma 52%
  32 引文 斯高帕斯（Scopus）
• 2010

  Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages

  Hsu, M. J., Chang, C. K., Chen, M. C., Chen, B. C., Ma, H. P., Hong, C-Y. & Lin, C. H., 6月 2010, 於: Journal of Leukocyte Biology. 87, 6, p. 1069-1082 14 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • MAP Kinase Kinase Kinase 5 100%
  • Peptidoglycan 76%
  • Transcription Factor AP-1 70%
  • Macrophages 44%
  • Luciferases 23%
  24 引文 斯高帕斯（Scopus）

• Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation

  Hsieh, C. Y., Liu, C. L., Hsu, M. J., Jayakumar, T., Chou, D. S., Wang, Y. H., Hsiao, G. & Sheu, J. R., 9月 2010, 於: Free Radical Biology and Medicine. 49, 5, p. 881-893 13 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Vitamin E 100%
  • Fenton Reaction 99%
  • Hydroxyl Radical 91%
  • Vascular Smooth Muscle 81%
  • Smooth Muscle Myocytes 73%
  11 引文 斯高帕斯（Scopus）

• Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages

  Tzeng, J. I., Chen, B. C., Chang, H. M., Wang, J. J., Sureshbabu, M., Chien, M. H., Hsu, M. J., Bien, M. Y., Chiu, W. T., Hong, C. Y. & Lin, C. H., 2月 2010, 於: Pharmacological Research. 61, 2, p. 162-166 5 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Peptidoglycan 100%
  • Type C Phospholipases 92%
  • Phosphatidylcholines 90%
  • Cyclooxygenase 2 87%
  • tricyclodecane-9-yl-xanthogenate 84%
  14 引文 斯高帕斯（Scopus）

• Nuclear-targeted inhibition of NF-κB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells

  Chou, Y. C., Sheu, J. R., Chung, C. L., Chen, C. Y., Lin, F. L., Hsu, M. J., Kuo, Y. H. & Hsiao, G., 3月 2010, 於: Chemico-Biological Interactions. 184, 3, p. 403-412 10 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • N-2-(4-bromophenyl) ethyl caffeamide 100%
  • Matrix Metalloproteinase 9 43%
  • Antiinflammatory 39%
  • Ethyl 29%
  • Protein 16%
  64 引文 斯高帕斯（Scopus）
• 2009

  Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells

  Kuo, C. T., Chen, B. C., Yu, C. C., Weng, C. M., Hsu, M. J., Chen, C. C., Chen, M. C., Teng, C. M., Pan, S. L., Bien, M. Y., Shih, C. H. & Lin, C. H., 2009, 於: Journal of Biomedical Science. 16, 1, 43.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • denbinobin 100%
  • MAP Kinase Kinase Kinase 5 72%
  • N-Acetyl-L-Cysteine 68%
  • Adenocarcinoma of Lung 49%
  • A549 Cells 31%
  33 引文 斯高帕斯（Scopus）

• Peptidoglycan induces cyclooxygenase-2 expression in macrophages by activating the neutral sphingomyelinase-ceramide pathway

  Chen, B. C., Chang, H. M., Hsu, M. J., Shih, C. M., Chiu, Y. H., Chiu, W. T. & Lin, C. H., 7月 31 2009, 於: Journal of Biological Chemistry. 284, 31, p. 20562-20573 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Sphingomyelin Phosphodiesterase 100%
  • Peptidoglycan 94%
  • Ceramide 89%
  • Ceramides 87%
  • Cyclooxygenase 2 77%
  11 引文 斯高帕斯（Scopus）

• Rac1 regulates peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway

  Chen, B. C., Kang, J. C., Lu, Y. T., Hsu, M. J., Liao, C. C., Chiu, W. T., Yeh, F. L. & Lin, C. H., 3月 2009, 於: Molecular Immunology. 46, 6, p. 1179-1188 10 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Peptidoglycan 100%
  • Cyclooxygenase 2 87%
  • Phosphatidylinositol 3-Kinase 84%
  • Macrophages 58%
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39%
  35 引文 斯高帕斯（Scopus）

• Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway

  Yu, C. C., Hsu, M. J., Kuo, M. L., Chen, R. F. C., Chen, M. C., Bai, K. J., Yu, M. C., Chen, B. C. & Lin, C-H., 6月 15 2009, 於: Journal of Immunology. 182, 12, p. 7916-7927 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • MAP Kinase Kinase Kinase 5 100%
  • Connective Tissue Growth Factor 84%
  • Transcription Factor AP-1 70%
  • Thrombin 62%
  • Fibroblasts 47%
  32 引文 斯高帕斯（Scopus）
• 2008

  Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction

  Kuo, C. T., Hsu, M. J., Chen, B. C., Chen, C. C., Teng, C. M., Pan, S. L. & Lin, C. H., 2月 28 2008, 於: Toxicology Letters. 177, 1, p. 48-58 11 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • denbinobin 100%
  • Apoptotic 53%
  • Adenocarcinoma of Lung 49%
  • Cell Death 32%
  • Apoptosis 28%
  58 引文 斯高帕斯（Scopus）
• 2007

  Apoptosis signal-regulating kinase 1 in amyloid β peptide-induced cerebral endothelial cell apoptosis

  Hsu, M. J., Hsu, C-Y., Chen, B. C., Chen, M. C., Ou, G. & Lin, C. H., 5月 23 2007, 於: Journal of Neuroscience. 27, 21, p. 5719-5729 11 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • MAP Kinase Kinase Kinase 5 100%
  • Amyloid 60%
  • Endothelial Cells 46%
  • p38 Mitogen-Activated Protein Kinases 43%
  • Peptides 40%
  73 引文 斯高帕斯（Scopus）