Mei-Chuan Chen

2023

Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade

Chang, C-H., Lin, B-J., Chen, C-H., Nguyen, N-L., Hsieh, T-H., Su, J-H. & Chen, M-C., 2023, 於: Marine Drugs. 21, 2

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2021

Arenarosides A-G, Polyhydroxylated Oleanane-Type Saponins from Polycarpaea arenaria and their Cytotoxic and Antiangiogenic Activities

Nguyen, N. L., Vo, T. H., Lin, Y. C., Liaw, C. C., Lu, M. K., Cheng, J. J., Chen, M. C. & Kuo, Y. H., 2月 26 2021, 於: Journal of Natural Products. 84, 2, p. 259-267 9 p.

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5 引文斯高帕斯（Scopus）

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., 1月 1 2021, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.

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3 引文斯高帕斯（Scopus）

Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent

Ojha, R., Chen, I. C., Hsieh, C. M., Nepali, K., Lai, R. W., Hsu, K. C., Lin, T. E., Pan, S. L., Chen, M. C. & Liou, J. P., 2021, (接受/付印) 於: Journal of Medicinal Chemistry. 64, 24, p. 17824-17845 22 p.

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9 引文斯高帕斯（Scopus）

2020

Bioassay-guided isolation and HPLC quantification of antiproliferative metabolites from Stahlianthus thorelii

Nguyen, N. L., Vo, T. H., Lin, Y. C., Liaw, C. C., Lin, Z. H., Chen, M. C. & Kuo, Y. H., 1月 28 2020, 於: Molecules. 25, 3, 551.

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4 引文斯高帕斯（Scopus）

CK1δ as a potential therapeutic target to treat bladder cancer

Lin, Y. C., Chen, M. C., Hsieh, T. H., Liou, J. P. & Chen, C. H., 4月 15 2020, 於: Aging. 12, 7, p. 5764-5780 17 p.

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9 引文斯高帕斯（Scopus）

Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells

Wu, W. C., Liu, Y. M., Liao, Y. H., Hsu, K. C., Lien, S. T., Chen, I. C., Lai, M. J., Li, Y. H., Pan, S. L., Chen, M. C. & Liou, J. P., 10月 1 2020, 於: European Journal of Medicinal Chemistry. 203, 112540.

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4 引文斯高帕斯（Scopus）

Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo

Ojha, R., Nepali, K., Chen, C. H., Chuang, K. H., Wu, T. Y., Lin, T. E., Hsu, K. C., Chao, M. W., Lai, M. J., Lin, M. H., Huang, H. L., Chang, C. D., Pan, S. L., Chen, M. C. & Liou, J. P., 3月 15 2020, 於: European Journal of Medicinal Chemistry. 190, 112086.

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23 引文斯高帕斯（Scopus）

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., 1月 1 2020, 於: European Journal of Medicinal Chemistry. 185, p. 111725 111725.

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38 引文斯高帕斯（Scopus）

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., 2月 1 2020, 於: Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.

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5 引文斯高帕斯（Scopus）

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., 1月 15 2019, 於: European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

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31 引文斯高帕斯（Scopus）

Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells

Nepali, K., Lin, M. H., Chao, M. W., Peng, S. J., Hsu, K. C., Eight Lin, T., Chen, M. C., Lai, M. J., Pan, S. L. & Liou, J. P., 10月 1 2019, 於: Bioorganic Chemistry. 91, 103119.

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10 引文斯高帕斯（Scopus）

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 5月 21 2019, 於: Oncotarget. 10, 36, p. 3430 1 p.

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3 引文斯高帕斯（Scopus）

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., 1月 1 2019, 於: Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

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8 引文斯高帕斯（Scopus）

MPT0G612, a novel HDAC6 inhibitor, induces apoptosis and suppresses ifn-Γ-induced programmed death-ligand 1 in human colorectal carcinoma cells

Chen, M. C., Lin, Y. C., Liao, Y. H., Liou, J. P. & Chen, C. H., 10月 2019, 於: Cancers. 11, 10, 1617.

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24 引文斯高帕斯（Scopus）

2017

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 2017, 於: Oncotarget. 8, 17, p. 28342-28358 17 p.

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46 引文斯高帕斯（Scopus）

Identification of 7-(4′-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells

Wu, T. Y., Cho, T. Y., Lu, C. K., Liou, J. P. & Chen, M. C., 12月 1 2017, 於: Scientific Reports. 7, 1, 12406.

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10 引文斯高帕斯（Scopus）

Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea

Chen, M. C., Cho, T. Y., Kuo, Y. H. & Lee, T. H., 9月 22 2017, 於: Journal of Natural Products. 80, 9, p. 2439-2446 8 p.

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16 引文斯高帕斯（Scopus）

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., 2月 15 2017, 於: European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

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19 引文斯高帕斯（Scopus）

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., 4月 7 2017, 於: Scientific Reports. 7, 46149.

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2016

Chemical Constituents from Termite-associated Xylaria acuminatilongissima YMJ623

Cho, T. Y., Wang, G. J., Ju, Y. M., Chen, M. C. & Lee, T. H., 5月 1 2016, 於: Journal of the Chinese Chemical Society. 63, 5, p. 404-409 6 p.

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4 引文斯高帕斯（Scopus）

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., 6月 9 2016, 於: Scientific Reports. 6, 27794.

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8 引文斯高帕斯（Scopus）

MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer

Huang, H. L., Chao, M. W., Li, Y. C., Chang, L. H., Chen, C-H., Chen, M. C., Cheng, C. C., Liou, J. P., Teng, C. M. & Pan, S. L., 8月 16 2016, 於: Scientific Reports. 6, 31664.

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12 引文斯高帕斯（Scopus）

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Chen, M-C., Huang, H-H., Lai, C-Y., Lin, Y-J., Liou, J-P., Lai, M-J., Li, Y-H., Teng, C-M. & Yang, C-R., 1月 5 2016, 於: Oncotarget. 7, 1, p. 402-17 16 p.

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20 引文斯高帕斯（Scopus）

2015

New whitening constituents from taiwan-native Pyracantha koidzumii: Structures and tyrosinase inhibitory analysis in human epidermalmelanocytes

Lin, R. D., Chen, M. C., Liu, Y. L., Lin, Y. T., Lu, M. K., Hsu, F-L. & Lee, M. H., 12月 2 2015, 於: International Journal of Molecular Sciences. 16, 12, p. 28598-28613 16 p.

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19 引文斯高帕斯（Scopus）

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 8月 27 2015, 於: Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

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27 引文斯高帕斯（Scopus）

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Liu, Y-M., Lee, H. Y., Lai, M-J., Pan, S. L., Huang, H-L., Kuo, F-C., Chen, M. C. & Liou, J. P., 8月 17 2015, 於: Organic and Biomolecular Chemistry. 13, 40, p. 10226-10235 10 p.

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14 引文斯高帕斯（Scopus）

R173W mutation of hydroxymethylbilane synthetase is associated with acute intermittent porphyria complicated with rhabdomyolysis: The first report

Chen, M. C., Chang, C. J., Lu, Y. H., Niu, D. M., Lou, H. Y. & Chang, C. C., 3月 13 2015, 於: Journal of Clinical Gastroenterology. 49, 3, p. 256-257 2 p.

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6 引文斯高帕斯（Scopus）

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., 6月 1 2015, 於: Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

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19 引文斯高帕斯（Scopus）

2014

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 5月 22 2014, 於: Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

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67 引文斯高帕斯（Scopus）

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 9月 1 2014, 於: Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

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9 引文斯高帕斯（Scopus）

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

Wu, S. Y., Pan, S. L., Xiao, Z. Y., Hsu, J. L., Chen, M. C., Lee, K. H. & Teng, C. M., 11月 5 2014, 於: PLoS ONE. 9, 11, e112220.

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13 引文斯高帕斯（Scopus）

Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo

Chen, C. H., Chen, M. C., Wang, J. C., Tsai, A. C., Chen, C. S., Liou, J. P., Pan, S. L. & Teng, C. M., 2014, 於: Clinical Cancer Research. 20, 5, p. 1274-1287 14 p.

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44 引文斯高帕斯（Scopus）

2013

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Chen, M. C., Chen, C. H., Wang, J. C., Tsai, A. C., Liou, J. P., Pan, S. L. & Teng, C. M., 9月 2013, 於: Cell Death and Disease. 4, 9, e810.

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70 引文斯高帕斯（Scopus）

TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells

Chen, M. C., Chen, C. H., Liu, Y. N., Wang, H. P., Pan, S. L. & Teng, C. M., 8月 19 2013, 於: Cancer Letters. 336, 2, p. 370-378 9 p.

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15 引文斯高帕斯（Scopus）

2012

Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo

Lai, C. Y., Tsai, A. C., Chen, M. C., Chang, L. H., Sun, H. L., Chang, Y. L., Chen, C. C., Teng, C. M. & Pan, S. L., 8月 13 2012, 於: PLoS One. 7, 8, e42192.

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30 引文斯高帕斯（Scopus）

QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells

Chen, M. C., Pan, S. L., Shi, Q., Xiao, Z., Lee, K. H., Li, T. K. & Teng, C. M., 1月 2012, 於: Cancer Science. 103, 1, p. 80-87 8 p.

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15 引文斯高帕斯（Scopus）

2011

Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression

Chen, C-H., Huang, P. H., Chu, P. C., Chen, M. C., Chou, C. C., Wang, D., Kulp, S. K., Teng, C. M., Wang, Q. & Chen, C. S., 3月 25 2011, 於: Journal of Biological Chemistry. 286, 12, p. 9968-9976 9 p.

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20 引文斯高帕斯（Scopus）

Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells

Chen, M. C., Chen, C-H., Chuang, H. C., Kulp, S. K., Teng, C. M. & Chen, C. S., 1月 2011, 於: Hepatology. 53, 1, p. 148-159 12 p.

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39 引文斯高帕斯（Scopus）

陳 美全

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陳美全