Kuo-Hsiang Chuang

2023

Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice With Acute Liver Failure

Wang, C. H., Chen, C. Y., Wang, K. H., Kao, A. P., Chen, Y. J., Lin, P. H., Chen, M., Wu, T. Y., Cheng, J. J., Lee, K. D. & Chuang, K. H., 1月 30 2023, 於: Stem cells translational medicine. 12, 1, p. 39-53 15 p.

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1 引文斯高帕斯（Scopus）

Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment

Wu, T. Y., Chen, M., Chen, I. C., Chen, Y. J., Chen, C. Y., Wang, C. H., Cheng, J. J., Nepali, K., Chuang, K. H. & Liou, J. P., 4月 2023, 於: Journal of Advanced Research. 46, p. 159-171

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2 引文斯高帕斯（Scopus）

2022

A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor

Chen, M., Sheu, M. T., Cheng, T. L., Roffler, S. R., Lin, S. Y., Chen, Y. J., Cheng, Y. A., Cheng, J. J., Chang, H. Y., Wu, T. Y., Kao, A. P., Ho, Y. S. & Chuang, K. H., 1月 7 2022, 於: Biomaterials Science. 10, 1, p. 202-215 14 p.

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3 引文斯高帕斯（Scopus）

A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies

Hsieh, Y. C., Liao, J. M., Chuang, K. H., Ho, K. W., Hong, S. T., Liu, H. J., Huang, B. C., Chen, I. J., Liu, Y. L., Wang, J. Y., Tsai, H. L., Su, Y. C., Wang, Y. T. & Cheng, T. L., 1月 31 2022, 於: Journal of Nanobiotechnology. 20, 1, p. 58 58.

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Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy

Cheng, W. J., Chuang, K. H., Lo, Y. J., Chen, M., Chen, Y. J., Roffler, S. R., Ho, H. O., Lin, S. Y. & Sheu, M. T., 4月 2022, 於: Journal of Controlled Release. 344, p. 235-248 14 p.

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4 引文斯高帕斯（Scopus）

Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer

Cheng, W. J., Lin, S. Y., Chuang, K. H., Chen, M., Ho, H. O., Chen, L. C., Hsieh, C. M. & Sheu, M. T., 2022, 於: International Journal of Nanomedicine. 17, p. 5353-5374 22 p.

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New ent-kaurene and germacrene derivatives from Mesona procumbens Hemseley and their biological activity

Ganzon, J. G., Liaw, C. C., Lin, Y. C., Lin, Z. H., Wang, C. H., Chen, C. Y., Chuang, K. H. & Kuo, Y. H., 2022, (接受/付印) 於: Natural Product Research.

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1 引文斯高帕斯（Scopus）

Oct-4 induces cisplatin resistance and tumor stem cell-like properties in endometrial carcinoma cells

Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., 2022, (接受/付印) 於: Taiwanese Journal of Obstetrics and Gynecology.

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2021

Active Tumoral/Tumor Environmental Dual-Targeting by Non-Covalently Arming with Trispecific Antibodies or Dual-Bispecific Antibodies on Docetaxel-Loaded mPEGylated Nanocarriers to Enhance Chemotherapeutic Efficacy and Minimize Systemic Toxicity

Cheng, W. J., Lin, S. Y., Chen, M., Chen, L. C., Ho, H. O., Chuang, K. H. & Sheu, M. T., 2021, 於: International Journal of Nanomedicine. 16, p. 4017-4030 14 p.

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4 引文斯高帕斯（Scopus）

Downregulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells

Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., 6月 2021, 於: Biotechnology and Applied Biochemistry. 68, 3, p. 676-682 7 p.

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6 引文斯高帕斯（Scopus）

In situ subcutaneously injectable thermosensitive PEG-PLGA diblock and PLGA-PEG-PLGA triblock copolymer composite as sustained delivery of bispecific anti-CD3 scFv T-cell/anti-EGFR Fab Engager (BiTEE)

Wei, P. S., Chen, Y. J., Lin, S. Y., Chuang, K. H., Sheu, M. T. & Ho, H. O., 11月 2021, 於: Biomaterials. 278, 121166.

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8 引文斯高帕斯（Scopus）

Interleukin-33 promotes invasiveness of human ovarian endometriotic stromal cells through the ST2/MAPK/MMP-9 pathway activated by 17β-estradiol

Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., 7月 2021, 於: Taiwanese Journal of Obstetrics and Gynecology. 60, 4, p. 658-664 7 p.

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3 引文斯高帕斯（Scopus）

2020

A Pilot Study of Silymarin as Supplementation to Reduce Toxicities in Metastatic Colorectal Cancer Patients Treated With First-Line FOLFIRI Plus Bevacizumab

Chang, T. K., Yin, T. C., Su, W. C., Tsai, H. L., Huang, C. W., Chen, Y. C., Li, C. C., Chen, P. J., Ma, C. J., Chuang, K. H., Cheng, T. L. & Wang, J. Y., 2020, 於: Oncology Research. 28, 7, p. 801-809 9 p.

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3 引文斯高帕斯（Scopus）

Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer

Cheng, Y. A., Wu, T. H., Wang, Y. M., Cheng, T. L., Chen, I. J., Lu, Y. C., Chuang, K. H., Wang, C. K., Chen, C. Y., Lin, R. A., Chen, H. J., Liao, T. Y., Liu, E. S. & Chen, F. M., 8月 27 2020, 於: Journal of Nanobiotechnology. 18, 1, p. 118 118.

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4 引文斯高帕斯（Scopus）

Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo

Ojha, R., Nepali, K., Chen, C. H., Chuang, K. H., Wu, T. Y., Lin, T. E., Hsu, K. C., Chao, M. W., Lai, M. J., Lin, M. H., Huang, H. L., Chang, C. D., Pan, S. L., Chen, M. C. & Liou, J. P., 3月 15 2020, 於: European Journal of Medicinal Chemistry. 190, 112086.

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19 引文斯高帕斯（Scopus）

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., 1月 1 2020, 於: European Journal of Medicinal Chemistry. 185, p. 111725 111725.

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35 引文斯高帕斯（Scopus）

2019

Development of an inflammatory tissue-selective chimeric TNF receptor

Lee, C. J., Wang, C. C., Chen, M., Chuang, K. H., Cheng, T. L., Jian, T. Y., Wang, Y. M., Huang, T. H., Liao, K. W. & Tzou, S. C., 1月 1 2019, 於: Cytokine. 113, p. 340-346 7 p.

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5 引文斯高帕斯（Scopus）

Modulation of tumor stem cell characteristics by 17β-estradiol in human mesenchymal stem cells derived from ovarian endometrioma

Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., 5月 2019, 於: Taiwanese Journal of Obstetrics and Gynecology. 58, 3, p. 338-344 7 p.

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4 引文斯高帕斯（Scopus）

Simply Mixing Poly Protein G with Detection Antibodies Enhances the Detection Limit and Sensitivity of Immunoassays

Chen, Y. J., Chen, M., Cheng, T. L., Roffler, S. R., Lin, S. Y., Hsu, H. L., Wang, C. H., Chen, C. Y., Kao, A. P., Cheng, J. J. & Chuang, K. H., 1月 1 2019, 於: Analytical Chemistry.

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3 引文斯高帕斯（Scopus）

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

Lu, Y. C., Chuang, C. H., Chuang, K. H., Chen, I. J., Huang, B. C., Lee, W. H., Wang, H. E., Li, J. J., Cheng, Y. A., Cheng, K. W., Wang, J. Y., Hsieh, Y. C., Lin, W. W. & Cheng, T. L., 6月 1 2019, 於: PLoS Biology. 17, 6, p. e3000286

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15 引文斯高帕斯（Scopus）

2018

Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors

Su, C. Y., Chen, M., Chen, L. C., Ho, Y. S., Ho, H. O., Lin, S. Y., Chuang, K. H. & Sheu, M. T., 11月 1 2018, 於: Drug Delivery. 25, 1, p. 1066-1079 14 p.

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19 引文斯高帕斯（Scopus）

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., Lee, K. H., Wu, S. Y., Chen, Y. F., Chuang, K. H., Shieh, D. B., Chen, Y. L., Tu, C. C., Tsui, W. L. & Wu, M. H., 1月 4 2018, 於: Oncogene. 37, 1, p. 116-127 12 p.

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24 引文斯高帕斯（Scopus）

Development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates

Chen, Y. J., Chen, M., Hsieh, Y. C., Su, Y. C., Wang, C. H., Cheng, C. M., Kao, A. P., Wang, K. H., Cheng, J. J. & Chuang, K. H., 12月 1 2018, 於: Scientific Reports. 8, 1, 17868.

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15 引文斯高帕斯（Scopus）

2017

Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy

Su, Y. C., Burnouf, P. A., Chuang, K. H., Chen, B. M., Cheng, T. L. & Roffler, S. R., 6月 8 2017, 於: Nature Communications. 8, 15507.

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49 引文斯高帕斯（Scopus）

Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays

Hao, W. R., Chen, M., Chen, Y. J., Su, C. Y., Cheng, C. M., Hsueh, H. Y., Kao, A. P., Hsieh, Y. C., Chang, J., Tseng, M. Y. & Chuang, K. H., 12月 1 2017, 於: Scientific Reports. 7, 1, 989.

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6 引文斯高帕斯（Scopus）

Pueraria mirifica inhibits 17β-estradiol-induced cell proliferation of human endometrial mesenchymal stem cells

Lin, T. C., Wang, K. H., Kao, A. P., Chuang, K. H. & Kuo, T. C., 12月 2017, 於: Taiwanese Journal of Obstetrics and Gynecology. 56, 6, p. 765-769 5 p.

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5 引文斯高帕斯（Scopus）

Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe

Chen, M., Cheng, K. W., Chen, Y. J., Wang, C. H., Cheng, T. C., Chang, K. C., Kao, A. P. & Chuang, K. H., 12月 1 2017, 於: Scientific Reports. 7, 1, 3142.

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25 引文斯高帕斯（Scopus）

2016

Engineering Chimeric Receptors To Investigate the Size- and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells

Huang, W-C., Burnouf, P-A., Su, Y-C., Chen, B-M., Chuang, K-H., Lee, C-W., Wei, P-K., Cheng, T-L. & Roffler, S. R., 1月 13 2016, 於: ACS Nano. 10, 1, p. 648-62 15 p.

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26 引文斯高帕斯（Scopus）

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

Chen, B. M., Su, Y. C., Chang, C. J., Burnouf, P. A., Chuang, K-H., Chen, C. H., Cheng, T. L., Chen, Y. T., Wu, J. Y. & Roffler, S. R., 11月 1 2016, 於: Analytical Chemistry. 88, 21, p. 10661-10666 6 p.

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100 引文斯高帕斯（Scopus）

Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules

Lin, W. W., Hsieh, Y. C., Cheng, Y-A., Chuang, K-H., Huang, C. C., Chuang, C. H., Chen, I. J., Cheng, K. W., Lu, Y-C., Cheng, T. C., Wang, Y. T., Roffler, S. R. & Cheng, T. L., 12月 20 2016, 於: Analytical Chemistry. 88, 24, p. 12371-12379 9 p.

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12 引文斯高帕斯（Scopus）

Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles

Hsieh, Y. C., Cheng, T. C., Wang, H. E., Li, J. J., Lin, W. W., Huang, C. C., Chuang, C. H., Wang, Y. T., Wang, J. Y., Roffler, S. R., Chuang, K-H. & Cheng, T. L., 12月 19 2016, 於: Scientific Reports. 6, 39119.

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7 引文斯高帕斯（Scopus）

2015

Direct coating of culture medium from cells secreting classical swine fever virus E2 antigen on ELISA plates for detection of E2-specific antibodies

Cheng, T. C., Pan, C. H., Chen, C. S., Chuang, K. H., Chuang, C. H., Huang, C. C., Chu, Y. Y., Yang, Y. C., Chu, P. Y., Kao, C. H., Hsieh, Y. C. & Cheng, T. L., 7月 1 2015, 於: Veterinary Journal. 205, 1, p. 107-109 3 p.

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7 引文斯高帕斯（Scopus）

Discovery of akt kinase inhibitors through structure-based virtual screening and their evaluation as potential anticancer agents

Chuang, C. H., Cheng, T. C., Leu, Y. L., Chuang, K. H., Tzou, S. C. & Chen, C. S., 2月 2 2015, 於: International journal of molecular sciences. 16, 2, p. 3202-3212 11 p.

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27 引文斯高帕斯（Scopus）

Discovery of specific inhibitors for intestinal E. coli β -glucuronidase through in silico virtual screening

Cheng, T. C., Chuang, K. H., Roffler, S. R., Cheng, K. W., Leu, Y. L., Chuang, C. H., Huang, C. C., Kao, C. H., Hsieh, Y. C., Chang, L. S., Cheng, T. L. & Chen, C. S., 2015, 於: Scientific World Journal. 2015, 740815.

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10 引文斯高帕斯（Scopus）

Selective delivery of PEGylated compounds to tumor cells by anti-PEG hybrid antibodies

Tung, H. Y., Su, Y. C., Chen, B. M., Burnouf, P. A., Huang, W. C., Chuang, K. H., Yan, Y. T., Cheng, T. L. & Roffler, S. R., 6月 1 2015, 於: Molecular Cancer Therapeutics. 14, 6, p. 1317-1326 10 p.

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30 引文斯高帕斯（Scopus）

2014

Development of an anti-methoxy poly(ethylene glycol) (α-mPEG) cell-based capture system to measure mPEG and mPEGylated molecules

Chuang, K. H., Kao, C. H., Roffler, S. R., Lu, S. J., Cheng, T. C., Wang, Y. M., Chuang, C. H., Hsieh, Y. C., Wang, Y. T., Wang, J. Y., Weng, K. Y. & Cheng, T. L., 10月 14 2014, 於: Macromolecules. 47, 19, p. 6880-6888 9 p.

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8 引文斯高帕斯（Scopus）

High-throughput sorting of the highest producing cell via a transiently protein-anchored system

Chuang, K. H., Hsieh, Y. C., Chiang, I. S., Chuang, C. H., Kao, C. H., Cheng, T. C., Wang, Y. T., Lin, W. W., Chen, B. M., Roffler, S. R., Huang, M. Y. & Cheng, T. L., 7月 18 2014, 於: PLoS One. 9, 7, e102569.

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7 引文斯高帕斯（Scopus）

Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies

Su, Y. C., Al-Qaisi, T. S., Tung, H. Y., Cheng, T. L., Chuang, K. H., Chen, B. M. & Roffler, S. R., 2014, 於: mAbs. 6, 4, p. 1069-1083 15 p.

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7 引文斯高帕斯（Scopus）

One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles

Kao, C. H., Wang, J. Y., Chuang, K. H., Chuang, C. H., Cheng, T. C., Hsieh, Y. C., Tseng, Y. L., Chen, B. M., Roffler, S. R. & Cheng, T. L., 12月 1 2014, 於: Biomaterials. 35, 37, p. 9930-9940 11 p.

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41 引文斯高帕斯（Scopus）

2013

Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length

Cheng, T. C., Chuang, K. H., Chen, M., Wang, H. E., Tzou, S. C., Su, Y. C., Chuang, C. H., Kao, C. H., Chen, B. M., Chang, L. S., Roffler, S. R. & Cheng, T. L., 8月 21 2013, 於: Bioconjugate Chemistry. 24, 8, p. 1408-1413 6 p.

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13 引文斯高帕斯（Scopus）

2012

An activity-based near-infrared glucuronide trapping probe for imaging β-glucuronidase expression in deep tissues

Cheng, T. C., Roffler, S. R., Tzou, S. C., Chuang, K. H., Su, Y. C., Chuang, C. H., Kao, C. H., Chen, C. S., Harn, I. H., Liu, K. Y., Cheng, T. L. & Leu, Y. L., 2月 15 2012, 於: Journal of the American Chemical Society. 134, 6, p. 3103-3110 8 p.

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73 引文斯高帕斯（Scopus）

A regularly spaced and self-revealing protein ladder for anti-tag Western blot analysis

Kao, C. H., Cheng, C. M., Chuang, K. H., Chuang, C. H., Tzou, S. C., Cheng, T. C., Hsieh, Y. C., Liao, K. W., Wang, Y. M., Chang, L. S., Roffler, S. R., Chen, F. M. & Cheng, T. L., 12月 1 2012, 於: Analytical Biochemistry. 431, 1, p. 1-3 3 p.

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5 引文斯高帕斯（Scopus）

In vivo positron emission tomography imaging of protease activity by generation of a hydrophobic product from a noninhibitory protease substrate

Chuang, C. H., Chuang, K. H., Wang, H. E., Roffler, S. R., Shiea, J. T., Tzou, S. C., Cheng, T. C., Kao, C. H., Wu, S. Y., Tseng, W. L., Cheng, C. M., Hou, M. F., Wang, J. M. & Cheng, T. L., 1月 1 2012, 於: Clinical Cancer Research. 18, 1, p. 238-247 10 p.

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27 引文斯高帕斯（Scopus）

2010

Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes

Chuang, K. H., Wang, H. E., Cheng, T. C., Tzou, S. C., Tseng, W. L., Hung, W. C., Tai, M. H., Chang, T. K., Roffler, S. R. & Cheng, T. L., 6月 2010, 於: Journal of Nuclear Medicine. 51, 6, p. 933-941 9 p.

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28 引文斯高帕斯（Scopus）

Endocytosis of PEGylated agents enhances cancer imaging and anticancer efficacy

Chuang, K. H., Wang, H. E., Chen, F. M., Tzou, S. C., Cheng, C. M., Chang, Y. C., Tseng, W. L., Shiea, J., Lin, S. R., Wang, J. Y., Chen, B. M., Roffler, S. R. & Cheng, T. L., 6月 2010, 於: Molecular Cancer Therapeutics. 9, 6, p. 1903-1912 10 p.

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29 引文斯高帕斯（Scopus）

Measurement of Poly(ethylene glycol) by Cell-Based Anti-poly(ethylene glycol) ELISA

Chuang, K. H., Tzou, S. C., Cheng, T. C., Kao, C. H., Tseng, W. L., Shiea, J., Liao, K. W., Wang, Y. M., Chang, Y. C., Huango, B. J., Wu, C. J., Chu, P. Y., Roffler, S. R. & Cheng, T. L., 3月 15 2010, 於: Analytical Chemistry. 82, 6, p. 2355-2362 8 p.

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22 引文斯高帕斯（Scopus）

Sensitive quantification of PEGylated compounds by second-generation anti-poly(ethylene glycol) monoclonal antibodies

Su, Y. C., Chen, B. M., Chuang, K. H., Cheng, T. L. & Roffler, S. R., 7月 21 2010, 於: Bioconjugate Chemistry. 21, 7, p. 1264-1270 7 p.

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74 引文斯高帕斯（Scopus）

2009

Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems

Cheng, C. M., Chu, P. Y., Chuang, K. H., Roffler, S. R., Kao, C. H., Tseng, W. L., Shiea, J., Chang, W. D., Su, Y. C., Chen, B. M., Wang, Y. M. & Cheng, T. L., 1月 2009, 於: Cancer Gene Therapy. 16, 1, p. 83-90 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

7 引文斯高帕斯（Scopus）

Micro-PET imaging of β-glucuronidase activity by the hydrophobic conversion of a glucuronide probe

Tzou, S. C., Roffler, S., Chuang, K. H., Yeh, H. P., Kao, C. H., Su, Y. C., Cheng, C. M., Tseng, W. L., Shiea, J., Harm, I. H., Cheng, K. W., Chen, B. M., Hwang, J. J., Cheng, T. L. & Wang, H. E., 9月 2009, 於: Radiology. 252, 3, p. 754-762 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

17 引文斯高帕斯（Scopus）

2008

Tumor-targeting prodrug-activating bacteria for cancer therapy

Cheng, C. M., Lu, Y. L., Chuang, K. H., Hung, W. C., Shiea, J., Su, Y. C., Kao, C. H., Chen, B. M., Roffler, S. & Cheng, T. L., 6月 2008, 於: Cancer Gene Therapy. 15, 6, p. 393-401 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

43 引文斯高帕斯（Scopus）

莊 國祥

研究成果

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莊國祥