許 準榕

研究成果

每年研究成果 1991 2003 2005 2011 2013 2014 2015 2017 2018 2023

• 285 文章
• 8 回顧型文獻
• 6 評論/辯論
• 3 社論
• 5 更多
  • 2 Erratum
  • 1 章節
  • 1 會議貢獻
  • 1 海报

每年研究成果

每年研究成果

搜尋結果

• 2023

  Attenuation of indoxyl sulfate–induced cell damage by cinchonidine—a Cinchona alkaloid—through the downregulation of p53 signaling pathway by promoting MDM2 cytoplasmic-nuclear shuttling in endothelial cells

  Teng, R. D., Yang, C. H., Chung, C. L., Sheu, J. R. & Hsieh, C. Y., 4月 1 2023, 於: Life Sciences. 318, 121477.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • indoxyl 100%
  • Cinchona 99%
  • cinchonidine 85%
  • Indoxyl 84%
  • Indican 78%
• 2022

  Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells

  Jayakumar, T., Huang, C. J., Yen, T. L., Hsia, C. W., Sheu, J. R., Bhavan, P. S., Huang, W. C., Hsieh, C. Y. & Hsia, C. H., 8月 2022, 於: Molecules. 27, 16, 5143.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • esculetin 100%
  • Esculetin 96%
  • RAW 264.7 Cells 77%
  • lipoteichoic acid 74%
  • NF-kappa B 63%
  4 引文 斯高帕斯（Scopus）

• Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules

  Jayakumar, T., Yang, C. M., Yen, T. L., Hsu, C. Y., Sheu, J. R., Hsia, C. W., Manubolu, M., Huang, W. C., Hsieh, C. Y. & Hsia, C. H., 6月 1 2022, 於: International journal of molecular sciences. 23, 11, 5889.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Alkaloids 98%
  • alkaloids 93%
  • Lipoteichoic Acid 87%
  • lipoteichoic acid 80%
  • Transcription factors 79%
  4 引文 斯高帕斯（Scopus）

• Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB

  Huang, W. C., Hou, S. M., Wu, M. P., Hsia, C. H., Jayakumar, T., Hsia, C. H., Bhavan, P. S., Chung, C. L. & Sheu, J. R., 1月 1 2022, 於: Molecules. 27, 2, 476.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • 3-(4-methylphenylsulfonyl)-2-propenenitrile 89%
  • thrombosis 85%
  • inhibitors 64%
  • Platelet Activation 61%
  • platelets 60%
  5 引文 斯高帕斯（Scopus）

• Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice

  Chung, C. L., Chen, J. H., Huang, W. C., Sheu, J. R., Hsia, C. W., Jayakumar, T., Hsia, C. H., Chiou, K. R. & Hou, S. M., 10月 2022, 於: International journal of molecular sciences. 23, 19, 11372.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • glabridin 100%
  • Glabridin 99%
  • Flavonoids 92%
  • Glycyrrhiza 75%
  • Platelets 69%
  3 引文 斯高帕斯（Scopus）

• Influence of Garlic (Allium sativum) Clove-Based Selenium Nanoparticles on Status of Nutritional, Biochemical, Enzymological, and Gene Expressions in the Freshwater Prawn Macrobrachium rosenbergii (De Man, 1879)

  Satgurunathan, T., Bhavan, P. S., Kalpana, R., Jayakumar, T., Sheu, J-R. & Manjunath, M., 6月 3 2022, (打印前電子出版) 於: Biological Trace Element Research.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Palaemonidae 100%
  • Syzygium 87%
  • Garlic 77%
  • Fresh Water 72%
  • Selenium 65%

• Targeting MAPK/NF-κB pathways in anti-inflammatory potential of rutaecarpine: Impact on Src/FAK-mediated macrophage migration

  Jayakumar, T., Lin, K. C., Chang, C. C., Hsia, C. H., Manubolu, M., Huang, W. C., Sheu, J. R. & Hsia, C. H., 1月 1 2022, 於: International journal of molecular sciences. 23, 1, 92.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Macrophages 93%
  • macrophages 80%
  • Transcription factors 79%
  • Lipopolysaccharide 61%
  • NF-kappa B 59%
  7 引文 斯高帕斯（Scopus）

• Yohimbine, an α2-Adrenoceptor Antagonist, Suppresses PDGF-BB-Stimulated Vascular Smooth Muscle Cell Proliferation by Downregulating the PLCγ1 Signaling Pathway

  Chiu, C. W., Hsieh, C. Y., Yang, C. H., Tsai, J. H., Huang, S. Y. & Sheu, J. R., 7月 2022, 於: International journal of molecular sciences. 23, 14, 8049.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Intercellular Signaling Peptides and Proteins 100%
  • Cell proliferation 97%
  • Yohimbine 95%
  • smooth muscle 94%
  • muscle cells 89%
• 2021

  Auraptene, a Monoterpene Coumarin, Inhibits LTA-Induced Inflammatory Mediators via Modulating NF- B/MAPKs Signaling Pathways

  Hsia, C. W., Jayakumar, T., Lu, W. J., Sheu, J. R., Hsia, C. W., Saravana Bhavan, P., Manubolu, M., Huang, W. C. & Chang, Y., 2021, 於: Evidence-based Complementary and Alternative Medicine. 2021, 5319584.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • aurapten 100%
  • Monoterpenes 78%
  • lipoteichoic acid 77%
  • coumarin 72%
  • RAW 264.7 Cells 19%
  4 引文 斯高帕斯（Scopus）

• Columbianadin dampens in vitro inflammatory actions and inhibits liver injury via inhibition of nf-κb/mapks: Impacts on oh^◦ radicals and ho-1 expression

  Jayakumar, T., Hou, S. M., Chang, C. C., Fong, T. H., Hsia, C. W., Chen, Y. J., Huang, W. C., Saravanabhavan, P., Manubolu, M., Sheu, J. R. & Hsia, C. H., 2021, 於: Antioxidants. 10, 4, 553.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • columbianadin 100%
  • Lipopolysaccharides 30%
  • Liver 23%
  • Wounds and Injuries 22%
  • In Vitro Techniques 20%
  7 引文 斯高帕斯（Scopus）

• Comparison of the potency of pterostilbene with nf-κb inhibitors in platelet activation: Mutual activation by akt-nf-κb signaling in human platelets

  Hsia, C. H., Huang, W. C., Yang, C. H., Hsia, C. H., Jayakumar, T., Bhavan, P. S., Sheu, J. R. & Chiou, K. R., 7月 1 2021, 於: Applied Sciences (Switzerland). 11, 13, 6149.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Pterostilbene 100%
  • Phosphorylation 92%
  • phosphorylation 80%
  • Platelets 73%
  • inhibitors 66%
  3 引文 斯高帕斯（Scopus）

• First record of a seed shrimp (Ostracoda: Podocopida) Cypretta campechensis (Cyprididae) in a perennial lake (Coimbatore, India): Its molecular identification

  Kalpana, R., Saravana Bhavan, P., Udayasuriyan, R., Sheu, J-R., Jayakumar, T. & Fong, TH., 2021, 於: International Journal of Fauna and Biological Studies . 8, 2

  研究成果: 雜誌貢獻 › 文章 › 同行評審

• Influence of vincristine, clinically used in cancer therapy and immune thrombocytopenia, on the function of human platelets

  Lien, L. M., Lu, W. J., Lin, K. H., Kang, L. H., Chen, T. Y., Lin, B. J., Lu, Y. C., Huang, C. Y., Shih, C. M., Chen, H., Tsai, Y. C., Chen, R. J. & Sheu, J. R., 9月 2021, 於: Molecules. 26, 17, 5340.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Vincristine 100%
  • Idiopathic Thrombocytopenic Purpura 80%
  • platelets 73%
  • therapy 64%
  • cancer 63%

• Involvement of antioxidant defenses and nf-κb/erk signaling in anti-inflammatory effects of pterostilbene, a natural analogue of resveratrol

  Jayakumar, T., Wu, M. P., Sheu, J. R., Hsia, C. H., Bhavan, P. S., Manubolu, M., Chung, C. L. & Hsia, C. H., 5月 2 2021, 於: Applied Sciences (Switzerland). 11, 10, 4666.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Resveratrol 100%
  • Pterostilbene 86%
  • antioxidants 69%
  • Antioxidants 67%
  • Nitric oxide 54%
  5 引文 斯高帕斯（Scopus）

• Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism

  Lee, T. Y., Lu, W. J., Changou, C. A., Hsiung, Y. C., Trang, N. T. T., Lee, C. Y., Chang, T. H., Jayakumar, T., Hsieh, C. Y., Yang, C. H., Chang, C. C., Chen, R. J., Sheu, J. R. & Lin, K. H., 4月 2021, 於: Autophagy. 17, 12, p. 1-18 18 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Sphingolipids 100%
  • Blood Platelets 63%
  • Thrombosis 62%
  • Autophagy 57%
  • Platelet Activation 35%
  7 引文 斯高帕斯（Scopus）

• Pterostilbene, a Dimethylether Analogue of Resveratrol, Possesses High Potency in the Prevention of Platelet Activation in Humans and the Reduction of Vascular Thrombosis in Mice

  Huang, W. C., Liu, J. C., Hsia, C. W., Fong, T. H., Hsia, C. H., Tran, O. T., Velusamy, M., Yang, C. H. & Sheu, J. R., 2021, (接受/付印) 於: Journal of Agricultural and Food Chemistry. 69, 16, p. 4697-4707 11 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Pterostilbene 100%
  • pterostilbene 96%
  • platelet activation 82%
  • Resveratrol 72%
  • resveratrol 69%
  6 引文 斯高帕斯（Scopus）

• Rutaecarpine, an alkaloid from evodia rutaecarpa, can prevent platelet activation in humans and reduce microvascular thrombosis in mice: crucial role of the pi3k/akt/gsk3β signal axis through a cyclic nucleotides/vasp—independent mechanism

  Huang, C. J., Huang, W. C., Lin, W. T., Shu, L. H., Sheu, J. R., Tran, O. T., Hsia, C. W., Jayakumar, T., Bhavan, P. S., Hsieh, C. Y. & Chang, C. C., 10月 1 2021, 於: International journal of molecular sciences. 22, 20, 11109.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Cyclic Nucleotides 100%
  • Alkaloids 88%
  • Evodia 86%
  • alkaloids 84%
  • thrombosis 77%
  9 引文 斯高帕斯（Scopus）

• The antithrombotic agent pterostilbene interferes with integrin αIIbβ3-mediated inside-out and outside-in signals in human platelets

  Huang, W. C., Lin, K. C., Hsia, C. H., Hsia, C. H., Chen, T. Y., Bhavan, P. S., Sheu, J. R. & Hou, S. M., 4月 1 2021, 於: International journal of molecular sciences. 22, 7, 3643.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Pterostilbene 100%
  • pterostilbene 96%
  • Platelets 73%
  • Anticoagulant Agent 73%
  • Fibrinolytic Agents 69%
  7 引文 斯高帕斯（Scopus）
• 2020

  Biomass and Lipid Production Potential of an Indian Marine Algal Isolate Tetraselmis striata BBRR1

  Boopathy, A. B., Jayakumar, T., Chinnasamy, S., Rajaram, M. G., Mohan, N., Nagaraj, S., Rengasamy, R., Manubolu, M., Sheu, J. R. & Chang, C. C., 1月 1 2020, 於: Energies. 13, 2, 341.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Algae 100%
  • Lipids 93%
  • Biomass 86%
  • Ponds 55%
  • Productivity 54%
  9 引文 斯高帕斯（Scopus）

• Carbon dot nanoparticles exert inhibitory effects on human platelets and reduce mortality in mice with acute pulmonary thromboembolism

  Lee, T. Y., Jayakumar, T., Thanasekaran, P., Lin, K. C., Chen, H. M., Veerakumar, P. & Sheu, J. R., 7月 2020, 於: Nanomaterials. 10, 7, p. 1-15 15 p., 1254.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Platelets 100%
  • Nanoparticles 76%
  • Proteins 71%
  • Carbon 58%
  • Chemical activation 55%
  6 引文 斯高帕斯（Scopus）

• Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: Regulation by integrin α_iIbβ₃ inside-out but not outside-in signals

  Hou, S. M., Hsia, C. W., Tsai, C. L., Hsia, C. H., Jayakumar, T., Velusamy, M. & Sheu, J. R., 5月 6 2020, 於: Journal of Biomedical Science. 27, 1, 60.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • columbianadin 100%
  • Platelet Activation 50%
  • Integrins 43%
  • Thrombosis 35%
  • Blood Vessels 27%
  13 引文 斯高帕斯（Scopus）

• Reduction of NF-κB signals in platelets and prolongation of platelet plug formation against high shear flow in whole blood on human subject by Columbianadin

  Hsia, C. W., Yang, C. H., Sheu, J. R., Hsia, C. H., Tsai, C. L., Huang, W. C., Chen, T. Y., Bhavan, P. S. & Chang, Y., 10月 2 2020, 於: Applied Sciences (Switzerland). 10, 20, p. 1-15 15 p., 7323.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • prolongation 68%
  • Shear flow 62%
  • Platelets 62%
  • plugs 53%
  • platelets 52%
  1 引文 斯高帕斯（Scopus）

• Regulation of human platelet activation and prevention of arterial thrombosis in mice by auraptene through inhibition of nf-κb pathway

  Hsia, C. W., Wu, M. P., Shen, M. Y., Hsia, C. H., Chung, C. L. & Sheu, J. R., 7月 2020, 於: International journal of molecular sciences. 21, 13, p. 1-14 14 p., 4810.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Auraptene 100%
  • aurapten 97%
  • thrombosis 80%
  • Platelets 66%
  • Platelet Activation 57%
  7 引文 斯高帕斯（Scopus）

• Ruthenium derivatives attenuate LPS-induced inflammatory responses and liver injury via suppressing NF-κB signaling and free radical production

  Jayakumar, T., Huang, H. C., Hsia, C. W., Fong, T. H., Khamrang, T., Velusamy, M., Manubolu, M., Sheu, J. R. & Hsia, C. H., 3月 2020, 於: Bioorganic Chemistry. 96, 103639.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Ruthenium 100%
  • Free Radicals 59%
  • Lipopolysaccharides 54%
  • Free Radical 50%
  • Liver 32%
  12 引文 斯高帕斯（Scopus）

• Synthetic ruthenium complex TQ-6 potently recovers cerebral ischemic stroke: Attenuation of microglia and platelet activation

  Hsia, C. W., Jayakumar, T., Sheu, J. R., Hsia, C. W., Huang, W. C., Velusamy, M. & Lien, L. M., 4月 2020, 於: Journal of Clinical Medicine. 9, 4, 996.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Ruthenium 100%
  • Platelet Activation 69%
  • Microglia 64%
  • Stroke 43%
  • Heme Oxygenase-1 29%
  4 引文 斯高帕斯（Scopus）
• 2019

  A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

  Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., 1月 1 2019, 於: Frontiers in Neuroscience. 13, JUN, 635.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Neurogenesis 100%
  • Schizophrenia 76%
  • Pathology 59%
  • Poly I-C 29%
  • Animals 11%
  13 引文 斯高帕斯（Scopus）

• Esculetin, A coumarin derivative, prevents thrombosis: Inhibitory signaling on PLCγ2-PKC-AKT activation in human platelets

  Hsia, C. W., Lin, K. C., Lee, T. Y., Hsia, C. H., Chou, D. S., Jayakumar, T., Velusamy, M. & Sheu, J. R., 6月 1 2019, 於: International Journal of Molecular Sciences. 20, 11, 2731.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • esculetin 100%
  • Esculetin 96%
  • thrombosis 92%
  • Coumarins 83%
  • Platelets 76%
  18 引文 斯高帕斯（Scopus）

• HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

  Sheu, J-R., Hsieh, C-Y., Jayakumar, T., Lin, G-Y., Lee, H-N., Huang, S-W. & Yang, C-H., 4月 18 2019, 於: Journal of Biomedical Science. 26, 1, 27.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Neurogenic 100%
  • Neurogenesis 62%
  • Stroke 40%
  • Time 21%
  • Genetic Suppression 15%
  12 引文 斯高帕斯（Scopus）

• Natural Coumarin Derivative Esculetin Regulates Platelet Activation via Modulating NF-κB Signaling in Cyclic Nucleotide-Independent Manner

  Hsia, C. W., Shyu, K. G., Jayakumar, T., Hsia, C. H., Velusamy, M., Yang, C. H. & Sheu, J. R., 2019, 於: Natural Product Communications. 14, 12

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • esculetin 100%
  • Esculetin 96%
  • platelet activation 85%
  • Coumarins 83%
  • vasodilator agents 72%
  4 引文 斯高帕斯（Scopus）

• New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

  Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., 3月 1 2019, 於: Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • beta-thujaplicin 100%
  • Hemorrhagic Shock 64%
  • Liver 27%
  • Wounds and Injuries 26%
  • Resuscitation 21%
  3 引文 斯高帕斯（Scopus）

• Protective effects of ammannia baccifera against ccl4-induced oxidative stress in rats

  Goodla, L., Manubolu, M., Pathakoti, K., Jayakumar, T., Sheu, J. R., Fraker, M., Tchounwou, P. B. & Poondamalli, P. R., 4月 2 2019, 於: International Journal of Environmental Research and Public Health. 16, 8, 1440.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Oxidative stress 100%
  • Antioxidants 77%
  • Rats 68%
  • oxidative stress 67%
  • antioxidant 62%
  21 引文 斯高帕斯（Scopus）

• Suppression of human platelet activation via integrin α_iibβ₃ outside-in independent signal and reduction of the mortality in pulmonary thrombosis by auraptene

  Hsia, C. W., Tsai, C. L., Sheu, J. R., Lu, W. J., Hsia, C. H., Velusamy, M., Jayakumar, T. & Li, J. Y., 11月 2 2019, 於: International Journal of Molecular Sciences. 20, 22, 5585.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Auraptene 100%
  • aurapten 97%
  • thrombosis 80%
  • mortality 72%
  • Platelets 66%
  7 引文 斯高帕斯（Scopus）

• Thrombin upregulates PAI-1 and mesothelial–mesenchymal transition through PAR-1 and contributes to tuberculous pleural fibrosis

  Hsieh, C. Y., Sheu, J. R., Yang, C. H., Chen, W. L., Tsai, J. H. & Chung, C. L., 10月 2 2019, 於: International Journal of Molecular Sciences. 20, 20, 5076.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Plasminogen Inactivators 100%
  • thrombin 62%
  • fibrosis 62%
  • Peptide Hydrolases 62%
  • protease 60%
  6 引文 斯高帕斯（Scopus）
• 2018

  Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model

  Wu, M. P., Chang, N. C., Chung, C. L., Chiu, W. C., Hsu, C. C., Chen, H. M., Sheu, J. R., Jayakumar, T., Chou, D. S. & Fong, T. H., 11月 18 2018, 於: BioMed Research International. 2018, p. 5816875 11 p., 5816875.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Connectin 100%
  • Muscle Contraction 72%
  • White 58%
  • Red 47%
  • Muscles 42%
  11 引文 斯高帕斯（Scopus）

• An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

  Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., 11月 14 2018, 於: Journal of Clinical Medicine. 7, 11

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Phospholipase D 100%
  • Blood Platelets 58%
  • Platelet Activation 46%
  • Platelet Aggregation 32%
  • Clot Retraction 16%
  6 引文 斯高帕斯（Scopus）

• Biofuel and biochemical analysis of amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond

  Rajaram, M. G., Nagaraj, S., Manjunath, M., Boopathy, A. B., Kurinjimalar, C., Rengasamy, R., Jayakumar, T., Sheu, J. R. & Li, J. Y., 6月 1 2018, 於: Energies. 11, 6, en11061341.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Diatoms 100%
  • Biomass 75%
  • Ponds 73%
  • Biofuels 61%
  • Fatty Acids 57%
  9 引文 斯高帕斯（Scopus）

• CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

  Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., 2月 2018, 於: Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Protein Phosphatase 2 100%
  • Ceramides 91%
  • Nitric Oxide Synthase Type II 81%
  • Polysaccharides 72%
  • RAW 264.7 Cells 67%
  17 引文 斯高帕斯（Scopus）

• Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

  Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., 3月 22 2018, 於: International Journal of Molecular Sciences. 19, 4, 939.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Metalloproteases 100%
  • beta-thujaplicin 97%
  • Cell death 77%
  • apoptosis 72%
  • antioxidants 72%
  23 引文 斯高帕斯（Scopus）

• Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation

  Shyu, R. S., Khamrang, T., Sheu, J. R., Hsia, C. W., Velusamy, M., Hsia, C. H., Chou, D. S. & Chang, C. C., 1月 1 2018, 於: Bioinorganic Chemistry and Applications. 2018, p. 8291393 8291393.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Iridium 100%
  • Platelet Activation 68%
  • Metallocene 55%
  • Collagen 47%
  • Platelet Aggregation 47%
  2 引文 斯高帕斯（Scopus）

• Mechanism of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study

  Wang, C. L., Yang, P. S., Tsao, J. T., Jayakumar, T., Wang, M. J., Sheu, J. R. & Chou, D. S., 1月 1 2018, 於: Molecular Medicine Reports. 17, 1, p. 2061-2069 9 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Electron Spin Resonance Spectroscopy 100%
  • Free Radicals 72%
  • Hepatocytes 64%
  • Free Radical 61%
  • Blood Platelets 60%
  1 引文 斯高帕斯（Scopus）

• Mechanisms of TQ-6, a Novel Ruthenium-Derivative Compound, against Lipopolysaccharide-Induced In Vitro Macrophage Activation and Liver Injury in Experimental Mice: The Crucial Role of p38 MAPK and NF-κB Signaling

  Hsia, C-H., Velusamy, M., Jayakumar, T., Chen, Y-J., Hsia, C-W., Tsai, J-H., Teng, R-D. & Sheu, J-R., 11月 19 2018, 於: Cells. 7, 11

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Ruthenium Compounds 100%
  • Macrophage Activation 60%
  • Lipopolysaccharide 57%
  • p38 Mitogen-Activated Protein Kinases 54%
  • Antiinflammatory 50%
  10 引文 斯高帕斯（Scopus）

• Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen–integrin α_{II b}β₃ binding in human platelets

  Hsia, C. H., Lu, W. J., Lin, K. H., Chou, D. S., Geraldine, P., Jayakuma, T., Chang, N. C. & Sheu, J. R., 4月 1 2018, 於: Journal of Cellular and Molecular Medicine. 22, 4, p. 2142-2152 11 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • norcantharidin 100%
  • Blood Platelets 44%
  • Integrins 30%
  • Fibrinogen 23%
  • Clot Retraction 12%
  7 引文 斯高帕斯（Scopus）

• Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation

  Shyu, K. G., Velusamy, M., Hsia, C. W., Yang, C. H., Hsia, C. H., Chou, D. S., Jayakumar, T., Sheu, J. R. & Li, J. Y., 5月 1 2018, 於: International Journal of Molecular Medicine. 41, 5, p. 2589-2600 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Organometallic Compounds 100%
  • Iridium 84%
  • Platelet Activation 57%
  • Platelet Aggregation 17%
  • Phospholipases 10%
  6 引文 斯高帕斯（Scopus）

• Novel therapeutic agent against platelet activation in vitro and arterial thrombosis in vivo by morin hydrate

  Hsia, C. W., Wu, M. P., Velusamy, M., Hsia, C. H., Chou, D. S., Tsai, C. L., Hsu, C. Y., Jayakumar, T., Chung, C. L. & Sheu, J. R., 8月 13 2018, 於: International Journal of Molecular Sciences. 19, 8, 2386.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • morin 100%
  • thrombosis 95%
  • Morin 87%
  • Platelets 79%
  • hydrates 72%
  9 引文 斯高帕斯（Scopus）

• Structure-antiplatelet activity relationships of novel ruthenium (ii) complexes: Investigation of its molecular targets

  Hsia, C. H., Jayakumar, T., Sheu, J. R., Tsao, S. Y., Velusamy, M., Hsia, C. W., Chou, D. S., Chang, C. C., Chung, C. L., Khamrang, T. & Lin, K. C., 2月 22 2018, 於: Molecules. 23, 2, 477.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Ruthenium 100%
  • ruthenium 77%
  • Structure-Activity Relationship 74%
  • platelets 68%
  • Collagen 59%
  4 引文 斯高帕斯（Scopus）

• Structure⁻Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases

  Yang, C. H., Hsia, C. W., Jayakumar, T., Sheu, J. R., Hsia, C. H., Khamrang, T., Chen, Y. J., Manubolu, M. & Chang, Y., 11月 19 2018, 於: International Journal of Molecular Sciences. 19, 11

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Iridium 100%
  • Thrombotic 96%
  • iridium 76%
  • Anticoagulant Agent 53%
  • Collagen 39%
  2 引文 斯高帕斯（Scopus）
• 2017

  A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

  Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y., 2月 6 2017, 於: Scientific Reports. 7, 42277.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • platonin 100%
  • Neuroprotection 50%
  • Medicine 35%
  • Stroke 32%
  • Middle Cerebral Artery Infarction 21%
  9 引文 斯高帕斯（Scopus）

• A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

  Hsia, C. H., Velusamy, M., Sheu, J. R., Khamrang, T., Jayakumar, T., Lu, W. J., Lin, K. H. & Chang, C. C., 12月 1 2017, 於: Scientific Reports. 7, 1, 9556.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • Organometallic Compound 100%
  • Agonist 55%
  • Thrombotic 44%
  • Cyclic Nucleotide 38%
  • Anticoagulant Agent 37%
  14 引文 斯高帕斯（Scopus）

• Antiplatelet activity of a newly synthesized novel ruthenium (II): A potential role for Akt/JNK signaling

  Khamrang, T., Hung, K. C., Hsia, C. H., Hsieh, C. Y., Velusamy, M., Jayakumar, T. & Sheu, J. R., 5月 2017, 於: International journal of molecular sciences. 18, 5, 916.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  開啟存取

  • Ruthenium 100%
  • Platelets 81%
  • Anticoagulant Agent 80%
  • ruthenium 77%
  • platelets 68%
  9 引文 斯高帕斯（Scopus）

• Development of benzimidazole derivatives as novel anti-platelet drugs

  Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., 1月 1 2017, 於: Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

  研究成果: 雜誌貢獻 › 文章 › 同行評審

  • benzimidazole 97%
  • Thrombin 72%
  • Benzimidazole 70%
  • Blood Platelets 53%
  • Platelet Aggregation 39%
  2 引文 斯高帕斯（Scopus）