Hsueh-Yun Lee

2023

6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers

Narwanti, I., Yu, Z. Y., Sethy, B., Lai, M. J., Lee, H. Y., Olena, P., Lee, S. B. & Liou, J. P., 10月 2023, 於: European Journal of Medicinal Chemistry. 258, 115505.

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CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents

Peng, C. M., Wang, S. W., Hwang, Y. L., Sun, W. C., Chiu, L. P., Liu, Y. T., Lai, Y. W. & Lee, H. Y., 4月 28 2023, 於: RSC Advances. 13, 19, p. 13169-13176 8 p.

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Definition of fatty acid transport protein-2 (FATP2) structure facilitates identification of small molecule inhibitors for the treatment of diabetic complications

Kumar, M., Gaivin, R. J., Khan, S., Fedorov, Y., Adams, D. J., Zhao, W., Lee, H. Y., Dai, X., Dealwis, C. G. & Schelling, J. R., 7月 31 2023, 於: International Journal of Biological Macromolecules. 244, 125328.

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In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer

Chang, C. D., Chao, M. W., Lee, H. Y., Liu, Y. T., Tu, H. J., Lien, S. T., Lin, T. E., Sung, T. Y., Yen, S. C., Huang, S. H., Hsu, K. C. & Pan, S. L., 2023, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 2166039.

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1 引文斯高帕斯（Scopus）

2022

A novel HDAC1/2 inhibitor suppresses colorectal cancer through apoptosis induction and cell cycle regulation

Lee, H. Y., Tang, D. W., Liu, C. Y. & Cho, E. C., 1月 25 2022, 於: Chemico-Biological Interactions. 352, 109778.

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6 引文斯高帕斯（Scopus）

Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases

Lee, S. B., Chang, T. Y., Lee, N. Z., Yu, Z. Y., Liu, C. Y. & Lee, H. Y., 1月 5 2022, 於: European Journal of Medicinal Chemistry. 227, 113904.

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3 引文斯高帕斯（Scopus）

Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors

Lin, T. E., Sung, L. C., Chao, M. W., Li, M., Zheng, J. H., Sung, T. Y., Hsieh, J. H., Yang, C. R., Lee, H. Y., Cho, E. C. & Hsu, K. C., 2022, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 37, 1, p. 226-235 10 p.

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3 引文斯高帕斯（Scopus）

2021

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., 1月 1 2021, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.

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3 引文斯高帕斯（Scopus）

Effect of phenylurea hydroxamic acids on histone deacetylase and VEGFR-2

Lee, S., Wang, S. W., Yu, C. L., Tai, H. C., Yen, J. Y., Tuan, Y. L., Wang, H. H., Liu, Y. T., Chen, S. S. & Lee, H. Y., 11月 15 2021, 於: Bioorganic and Medicinal Chemistry. 50, 116454.

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1 引文斯高帕斯（Scopus）

Ring size changes in the development of class I HDAC inhibitors

Cho, E. C., Liu, C. Y., Tang, D. W. & Lee, H. Y., 12月 2021, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 1387-1401 15 p.

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1 引文斯高帕斯（Scopus）

2020

HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen-glucose deprivation injuries via H3K14 and H4K5 acetylation-mediated BDNF expression

Fang, Y-C., Chan, L., Liou, J-P., Tu, Y-K., Lai, M-J., Chen, C-I., Vidyanti, A. N., Lee, H-Y. & Hu, C-J., 6月 1 2020, 於: Journal of Cellular and Molecular Medicine. 24, 12, p. 6966-6977 12 p.

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7 引文斯高帕斯（Scopus）

Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment

Kaur, N., Fang, Y. C., Lee, H. Y., Singh, A., Nepali, K., Lin, M. H., Yeh, T. K., Lai, M. J., Chan, L., Tu, Y. K., Banerjee, S., Hu, C. J. & Liou, J. P., 2月 1 2020, 於: European Journal of Medicinal Chemistry. 187, 111915.

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11 引文斯高帕斯（Scopus）

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., 2月 1 2020, 於: Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.

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5 引文斯高帕斯（Scopus）

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., 1月 15 2019, 於: European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

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31 引文斯高帕斯（Scopus）

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Misko, T. A., Liu, Y. T., Harris, M. E., Oleinick, N. L., Pink, J., Lee, H. Y. & Dealwis, C. G., 1月 1 2019, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 438-450 13 p.

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12 引文斯高帕斯（Scopus）

2018

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 2月 8 2018, 於: Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

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60 引文斯高帕斯（Scopus）

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 8月 23 2018, 於: Journal of Medicinal Chemistry. 61, 16, p. 7087-7102 16 p.

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52 引文斯高帕斯（Scopus）

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 3月 13 2018, 於: Frontiers in Pharmacology. 9, MAR, 205.

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23 引文斯高帕斯（Scopus）

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 1月 1 2018, 於: Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

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2017

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 1月 5 2017, 於: European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

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36 引文斯高帕斯（Scopus）

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於: Oncotarget. 8, 17, p. 27772-27785 14 p.

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6 引文斯高帕斯（Scopus）

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., 2月 15 2017, 於: European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

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19 引文斯高帕斯（Scopus）

Total Synthesis of Two Glycosylated Stilbenes, Oxyresveratrol 2-O-β- d -Glucopyranoside and 2,3,5,4′-Tetrahydroxystilbene 2-O-β- d -Glucopyranoside

Kumar, S., Lee, H. Y. & Liou, J. P., 5月 26 2017, 於: Journal of Natural Products. 80, 5, p. 1294-1301 8 p.

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6 引文斯高帕斯（Scopus）

2016

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., 10月 21 2016, 於: European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

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25 引文斯高帕斯（Scopus）

Total Synthesis of Denbinobin

Lee, H. Y., Kumar, S., Lin, T. C. & Liou, J. P., 4月 22 2016, 於: Journal of Natural Products. 79, 4, p. 1170-1173 4 p.

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9 引文斯高帕斯（Scopus）

2015

1-arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells

Liu, Y-M., Lee, H. Y., Chen, C-H., Lee, C-H., Wang, L-T., Pan, S. L., Lai, M-J., Yeh, T-K. & Liou, J. P., 1月 2015, 於: European Journal of Medicinal Chemistry. 89, p. 320-330 11 p.

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20 引文斯高帕斯（Scopus）

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, 於: Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

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9 引文斯高帕斯（Scopus）

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes

Lee, H. Y., Chang, C-Y., Lai, M-J., Chuang, H-Y., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 7月 23 2015, 於: Bioorganic and Medicinal Chemistry. 23, 15, p. 4230-4236 7 p.

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17 引文斯高帕斯（Scopus）

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo

Huang, H-L., Peng, C-Y., Lai, M-J., Chen, C-H., Lee, H. Y., Wang, J-C., Liou, J. P., Pan, S. L. & Teng, C-M., 2015, 於: Oncotarget. 6, 7, p. 4976-4991 16 p.

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14 引文斯高帕斯（Scopus）

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 8月 27 2015, 於: Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

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27 引文斯高帕斯（Scopus）

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Liu, Y-M., Lee, H. Y., Lai, M-J., Pan, S. L., Huang, H-L., Kuo, F-C., Chen, M. C. & Liou, J. P., 8月 17 2015, 於: Organic and Biomolecular Chemistry. 13, 40, p. 10226-10235 10 p.

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14 引文斯高帕斯（Scopus）

2014

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, 於: Oncotarget. 5, 20, p. 9838-9850 13 p.

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10 引文斯高帕斯（Scopus）

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5- trimethoxybenzophenones

Chang, C. Y., Chuang, H. Y., Lee, H. Y., Yeh, T. K., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 4月 22 2014, 於: European Journal of Medicinal Chemistry. 77, p. 306-314 9 p.

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9 引文斯高帕斯（Scopus）

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 5月 22 2014, 於: Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

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67 引文斯高帕斯（Scopus）

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 9月 1 2014, 於: Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

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9 引文斯高帕斯（Scopus）

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Yang, C. R., Shih, K. S., Liou, J. P., Wu, Y. W., Hsieh, I. N., Lee, H. Y., Lin, T. C. & Wang, J. H., 10月 22 2014, 於: Journal of Molecular Medicine. 92, 11, p. 1147-1158 12 p.

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38 引文斯高帕斯（Scopus）

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., 11月 28 2014, 於: Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

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8 引文斯高帕斯（Scopus）

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Mehndiratta, S., Hsieh, Y. L., Liu, Y. M., Wang, A. W., Lee, H. Y., Liang, L. Y., Kumar, S., Teng, C. M., Yang, C. R. & Liou, J. P., 10月 6 2014, 於: European Journal of Medicinal Chemistry. 85, p. 468-479 12 p.

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40 引文斯高帕斯（Scopus）

Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

Hsieh, I-N., Liou, J. P., Lee, H. Y., Lai, M-J., Li, Y-H. & Yang, C-R., 4月 2014, 於: Cell Death and Disease. 5, 4, e1166.

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29 引文斯高帕斯（Scopus）

Tubulin inhibitors: A patent review

Liu, Y. M., Chen, H. L., Lee, H. Y. & Liou, J. P., 1月 2014, 於: Expert Opinion on Therapeutic Patents. 24, 1, p. 69-88 20 p.

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77 引文斯高帕斯（Scopus）

2013

1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., 7月 2013, 於: ChemBioChem. 14, 10, p. 1248-1254 7 p.

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18 引文斯高帕斯（Scopus）

Furanylazaindoles: Potent anticancer agents in vitro and in vivo

Lee, H. Y., Pan, S. L., Su, M-C., Liu, Y-M., Kuo, C-C., Chang, Y-T., Wu, J-S., Nien, C-Y., Mehndiratta, S., Chang, C-Y., Wu, S-Y., Lai, M-J., Chang, J-Y. & Liou, J. P., 2013, 於: Journal of Medicinal Chemistry. 56, 20, p. 8008-8018 11 p.

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47 引文斯高帕斯（Scopus）

Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., 7月 2013, 於: ChemBioChem. 14, 10, p. 1150 1 p.

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2012

Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo

Huang, H-L., Lee, H. Y., Tsai, A-C., Peng, C-Y., Lai, M-J., Wang, J-C., Pan, S. L., Teng, C-M. & Liou, J. P., 8月 22 2012, 於: PLoS ONE. 7, 8, e43645.

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32 引文斯高帕斯（Scopus）

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines

Lee, H. Y., Lee, L. W., Nien, C. Y., Kuo, C. C., Lin, P. Y., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2012, 於: Organic and Biomolecular Chemistry. 10, 48, p. 9593-9600 8 p.

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6 引文斯高帕斯（Scopus）

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N -hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo

Lai, M. J., Huang, H. L., Pan, S. L., Liu, Y. M., Peng, C. Y., Lee, H. Y., Yeh, T. K., Huang, P. H., Teng, C. M., Chen, C. S., Chuang, H. Y. & Liou, J. P., 4月 26 2012, 於: Journal of Medicinal Chemistry. 55, 8, p. 3777-3791 15 p.

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62 引文斯高帕斯（Scopus）

2011

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H-Y., Chang, J-Y., Lai, M-J., Kuo, C-C., Lee, H. Y., Hsieh, H-P., Chen, Y-J., Chen, L-T., Pan, W-Y. & Liou, J. P., 3月 7 2011, 於: ChemMedChem. 6, 3, p. 450-456 7 p.

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13 引文斯高帕斯（Scopus）

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 12月 22 2011, 於: Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

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54 引文斯高帕斯（Scopus）

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J-Y., Chang, L-Y., Lai, W-Y., Lai, M-J., Shih, K-H., Kuo, C-C., Chang, C-Y. & Liou, J. P., 5月 7 2011, 於: Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

22 引文斯高帕斯（Scopus）

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Lai, M-J., Chang, J-Y., Lee, H. Y., Kuo, C-C., Lin, M. H., Hsieh, H-P., Chang, C-Y., Wu, J-S., Wu, S-Y., Shey, K-S. & Liou, J. P., 9月 2011, 於: European Journal of Medicinal Chemistry. 46, 9, p. 3623-3629 7 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

33 引文斯高帕斯（Scopus）

李 學耘

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李學耘