Cheng-ying Hsieh

2025

Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages

Hou, S. M., Yang, C. M., Huang, W. C., Cheng, S. W., Yen, T. L., Hsia, C. W., Hsieh, C. Y. & Hsia, C. H., 2月 2025, 於: Biomolecules. 15, 2, 174.

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2023

Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice

Lu, K. J., Sheu, J. R., Teng, R. D., Jayakumar, T., Chung, C. L. & Hsieh, C. Y., 2023, 於: International Journal of Biological Sciences. 19, 9, p. 2835-2847 13 p.

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12 引文斯高帕斯（Scopus）

Attenuation of indoxyl sulfate–induced cell damage by cinchonidine—a Cinchona alkaloid—through the downregulation of p53 signaling pathway by promoting MDM2 cytoplasmic-nuclear shuttling in endothelial cells

Teng, R. D., Yang, C. H., Chung, C. L., Sheu, J. R. & Hsieh, C. Y., 4月 1 2023, 於: Life Sciences. 318, 121477.

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Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules

Hsieh, C. Y., Jayakumar, T., Lin, K. C., Yen, T. L., Hsia, C. W., Huang, W. C., Sheu, J. R. & Hsia, C. H., 2023, 於: European Journal of Inflammation. 21

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3 引文斯高帕斯（Scopus）

Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice

Lu, K. J., Yang, C. H., Sheu, J. R., Chung, C. L., Jayakumar, T., Chen, C. M. & Hsieh, C. Y., 11月 2023, 於: Translational Research. 261, p. 57-68 12 p.

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1 引文斯高帕斯（Scopus）

2022

Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells

Jayakumar, T., Huang, C. J., Yen, T. L., Hsia, C. W., Sheu, J. R., Bhavan, P. S., Huang, W. C., Hsieh, C. Y. & Hsia, C. H., 8月 2022, 於: Molecules. 27, 16, 5143.

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26 引文斯高帕斯（Scopus）

Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules

Jayakumar, T., Yang, C. M., Yen, T. L., Hsu, C. Y., Sheu, J. R., Hsia, C. W., Manubolu, M., Huang, W. C., Hsieh, C. Y. & Hsia, C. H., 6月 1 2022, 於: International journal of molecular sciences. 23, 11, 5889.

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16 引文斯高帕斯（Scopus）

Metformin Serves as a Novel Drug Treatment for Arterial Thrombosis: Inhibitory Mechanisms on Collagen-Induced Human Platelet Activation

Chang, Y., Huang, W. C., Hsu, C. Y., Hsia, C. W., Jayakumar, T., Hsieh, C. Y., Lu, W. J. & Chang, C. C., 8月 2022, 於: Applied Sciences (Switzerland). 12, 15, 7426.

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1 引文斯高帕斯（Scopus）

Yohimbine, an α2-Adrenoceptor Antagonist, Suppresses PDGF-BB-Stimulated Vascular Smooth Muscle Cell Proliferation by Downregulating the PLCγ1 Signaling Pathway

Chiu, C. W., Hsieh, C. Y., Yang, C. H., Tsai, J. H., Huang, S. Y. & Sheu, J. R., 7月 2022, 於: International journal of molecular sciences. 23, 14, 8049.

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9 引文斯高帕斯（Scopus）

2021

Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism

Lee, T. Y., Lu, W. J., Changou, C. A., Hsiung, Y. C., Trang, N. T. T., Lee, C. Y., Chang, T. H., Jayakumar, T., Hsieh, C. Y., Yang, C. H., Chang, C. C., Chen, R. J., Sheu, J. R. & Lin, K. H., 4月 2021, 於: Autophagy. 17, 12, p. 1-18 18 p.

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33 引文斯高帕斯（Scopus）

Platonin, a cyanine photosensitizing dye, ameliorates inflammatory responses in vascular smooth muscle cells by modulating inflammatory transcription factors

Chiu, C. W., Yang, C. H., Tsai, J. H., Hsieh, C. Y. & Huang, S. Y., 2月 1 2021, 於: Applied Sciences (Switzerland). 11, 3, p. 1-13 13 p., 1130.

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2 引文斯高帕斯（Scopus）

Rutaecarpine, an alkaloid from evodia rutaecarpa, can prevent platelet activation in humans and reduce microvascular thrombosis in mice: crucial role of the pi3k/akt/gsk3β signal axis through a cyclic nucleotides/vasp—independent mechanism

Huang, C. J., Huang, W. C., Lin, W. T., Shu, L. H., Sheu, J. R., Tran, O. T., Hsia, C. W., Jayakumar, T., Bhavan, P. S., Hsieh, C. Y. & Chang, C. C., 10月 1 2021, 於: International journal of molecular sciences. 22, 20, 11109.

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18 引文斯高帕斯（Scopus）

TQ-6, a novel ruthenium derivative compound, possesses potent free radical scavenging activity in macrophages and rats

Hung, K. W., Chang, C. C., Jayakumar, T., Velusamy, M., Hsia, C. W., Trang, N. T. T., Chou, D. S., Hsieh, C. Y. & Hsia, C. H., 2月 1 2021, 於: Applied Sciences (Switzerland). 11, 3, p. 1-13 13 p., 1008.

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1 引文斯高帕斯（Scopus）

2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., 1月 1 2019, 於: Frontiers in Neuroscience. 13, JUN, 635.

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21 引文斯高帕斯（Scopus）

Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions

Wu, Z.-H., Tsai, J.-H., Hsieh, C.-Y., Chen, W.-L. & Chung, C.-L., 3月 29 2019, 於: Journal of Clinical Medicine. 8, 4, 426.

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1 引文斯高帕斯（Scopus）

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Sheu, J.-R., Hsieh, C.-Y., Jayakumar, T., Lin, G.-Y., Lee, H.-N., Huang, S.-W. & Yang, C.-H., 4月 18 2019, 於: Journal of Biomedical Science. 26, 1, 27.

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18 引文斯高帕斯（Scopus）

Thrombin upregulates PAI-1 and mesothelial–mesenchymal transition through PAR-1 and contributes to tuberculous pleural fibrosis

Hsieh, C. Y., Sheu, J. R., Yang, C. H., Chen, W. L., Tsai, J. H. & Chung, C. L., 10月 2 2019, 於: International Journal of Molecular Sciences. 20, 20, 5076.

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7 引文斯高帕斯（Scopus）

2018

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., 2月 2018, 於: Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

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21 引文斯高帕斯（Scopus）

Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., 3月 22 2018, 於: International journal of molecular sciences. 19, 4, 939.

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39 引文斯高帕斯（Scopus）

Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53

Li, J.-Y., Liu, C.-P., Shiao, W.-C., Jayakumar, T., Li, Y.-S., Chang, N.-C., Huang, S.-Y. & Hsieh, C.-Y., 1月 1 2018, 於: Archives of Medical Science. 14, 3, p. 579-587 9 p.

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17 引文斯高帕斯（Scopus）

Neuroprotective effects of platonin, a therapeutic immunomodulating medicine, on traumatic brain injury in mice after controlled cortical impact

Yen, T. L., Chang, C. C., Chung, C. L., Ko, W. C., Yang, C. H. & Hsieh, C. Y., 4月 6 2018, 於: International Journal of Molecular Sciences. 19, 4, 1100.

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14 引文斯高帕斯（Scopus）

2017

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y., 2月 6 2017, 於: Scientific Reports. 7, 42277.

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10 引文斯高帕斯（Scopus）

Antiplatelet activity of a newly synthesized novel ruthenium (II): A potential role for Akt/JNK signaling

Khamrang, T., Hung, K. C., Hsia, C. H., Hsieh, C. Y., Velusamy, M., Jayakumar, T. & Sheu, J. R., 5月 2017, 於: International journal of molecular sciences. 18, 5, 916.

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12 引文斯高帕斯（Scopus）

2016

Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats

Yen, T. L., Chen, R.-J., Jayakumar, T., Lu, W. J., Hsieh, C.-Y., Hsu, M.-J., Yang, C. H., Chang, C. C., Lin, Y.-K., Lin, K. H. & Sheu, J.-R., 4月 1 2016, 於: Translational Research. 170, p. 57-72 16 p.

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74 引文斯高帕斯（Scopus）

Major vault protein regulates cell growth/survival signaling through oxidative modifications

Das, D., Wang, Y. H., Hsieh, C. Y. & Suzuki, Y. J., 1月 1 2016, 於: Cellular Signalling. 28, 1, p. 12-18 7 p.

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16 引文斯高帕斯（Scopus）

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W.-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., 2月 1 2016, 於: Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

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37 引文斯高帕斯（Scopus）

2015

Antiproliferative activity of hinokitiol, a tropolone derivative, is mediated via the inductions of p-JNK and p-PLCγ1 signaling in PDGF-BB-Stimulated vascular smooth muscle cells

Yang, P. S., Wang, M. J., Jayakumar, T., Chou, D. S., Ko, C. Y., Hsu, M. J. & Hsieh, C. Y., 5月 1 2015, 於: Molecules. 20, 5, p. 8198-8212 15 p.

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17 引文斯高帕斯（Scopus）

2014

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

Chen, Y. Y., Hsieh, C. Y., Jayakumar, T., Lin, K. H., Chou, D. S., Lu, W.-J., Hsu, M. J. & Sheu, J. R., 7月 10 2014, 於: Scientific Reports. 4, 5651.

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31 引文斯高帕斯（Scopus）

Andrographolide inhibits nuclear factor- B activation through JNK-Akt-p65 signaling cascade in tumor necrosis factor- α -Stimulated vascular smooth muscle cells

Chen, Y. Y., Hsu, M. J., Hsieh, C. Y., Lee, L. W., Chen, Z. C. & Sheu, J. R., 2014, 於: Scientific World Journal. 2014, 10 p., 130381.

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25 引文斯高帕斯（Scopus）

PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells

Hsieh, C. Y., Hsiao, G., Hsu, M. J., Wang, Y. H. & Sheu, J. R., 7月 2014, 於: Journal of Cellular and Molecular Medicine. 18, 7, p. 1278-1289 12 p.

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11 引文斯高帕斯（Scopus）

2013

Andrographolide, a novel NF- B inhibitor, induces vascular smooth muscle cell apoptosis via a ceramide-p47phox-ROS signaling cascade

Chen, Y. Y., Hsu, M. J., Sheu, J. R., Lee, L. W. & Hsieh, C. Y., 2013, 於: Evidence-based Complementary and Alternative Medicine. 2013, 821813.

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32 引文斯高帕斯（Scopus）

A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: Ex vivo and in vivo studies

Jayakumar, T., Chen, W. F., Lu, W.-J., Chou, D. S., Hsiao, G., Hsu, C.-Y., Sheu, J. R. & Hsieh, C. Y., 6月 2013, 於: Journal of Nutritional Biochemistry. 24, 6, p. 1086-1095 10 p.

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49 引文斯高帕斯（Scopus）

IL-22 activates oxidant signaling in pulmonary vascular smooth muscle cells

Bansal, G., Das, D., Hsieh, C. Y., Wang, Y. H., Gilmore, B. A., Wong, C. M. & Suzuki, Y. J., 12月 2013, 於: Cellular Signalling. 25, 12, p. 2727-2733 7 p.

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20 引文斯高帕斯（Scopus）

Novel bioactivity of ellagic acid in inhibiting human platelet activation

Chang, Y., Chen, W. F., Lin, K. H., Hsieh, C. Y., Chou, D. S., Lin, L. J., Sheu, J. R. & Chang, C. C., 2013, 於: Evidence-based Complementary and Alternative Medicine. 2013, 595128.

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24 引文斯高帕斯（Scopus）

2012

Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (humulus lupulus), in ischemic stroke of rats

Yen, T. L., Hsu, C. K., Lu, W.-J., Hsieh, C.-Y., Hsiao, G., Chou, D.-S., Wu, G.-J. & Sheu, J.-R., 2月 29 2012, 於: Journal of Agricultural and Food Chemistry. 60, 8, p. 1937-1944 8 p.

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87 引文斯高帕斯（Scopus）

2011

Andrographolide enhances nuclear factor-κB subunit p65 Ser ⁵³⁶ dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells

Hsieh, C. Y., Hsu, M. J., Hsiao, G., Wang, Y. H., Huang, C. W., Chen, S. W., Jayakumar, T., Chiu, P. T., Chiu, Y. H. & Sheu, J. R., 2月 25 2011, 於: Journal of Biological Chemistry. 286, 8, p. 5942-5955 14 p.

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81 引文斯高帕斯（Scopus）

Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells

Lu, Y. C., Jayakumar, T., Duann, Y. F., Chou, Y. C., Hsieh, C. Y., Yu, S. Y., Sheu, J. R. & Hsiao, G., 5月 11 2011, 於: Journal of Agricultural and Food Chemistry. 59, 9, p. 4969-4978 10 p.

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54 引文斯高帕斯（Scopus）

Platonin inhibited PDGF-BB-induced proliferation of rat vascular smooth muscle cells via JNK1/2-dependent signaling

Chang, Y., Uen, Y. H., Chen, C. C., Lin, S.-C., Tseng, S. Y., Wang, Y. H., Sheu, J. R. & Hsieh, C. Y., 11月 2011, 於: Acta Pharmacologica Sinica. 32, 11, p. 1337-1344 8 p.

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12 引文斯高帕斯（Scopus）

2010

Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation

Hsieh, C. Y., Liu, C. L., Hsu, M. J., Jayakumar, T., Chou, D. S., Wang, Y. H., Hsiao, G. & Sheu, J. R., 9月 2010, 於: Free Radical Biology and Medicine. 49, 5, p. 881-893 13 p.

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12 引文斯高帕斯（Scopus）

Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: The pivotal role of PKC-α translocation

Chang, C. C., Lee, J. J., Chiang, C.-W., Jayakumar, T., Hsiao, G., Hsieh, C. Y. & Sheu, J. R., 8月 2010, 於: Pharmaceutical Biology. 48, 8, p. 938-946 9 p.

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7 引文斯高帕斯（Scopus）

2009

Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activation

Sheu, J. R., Chang, Y., Lee, J. J., Hsieh, C. Y., Hsiao, G. & Chou, D. S., 2009, 於: Mediators of Inflammation. 2009, 705379.

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93 引文斯高帕斯（Scopus）

Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats

Chang, Y., Hsieh, C. Y., Peng, Z. A., Yen, T. L., Hsiao, G., Chou, D. S., Chen, C. M. & Sheu, J. R., 2009, 於: Journal of Biomedical Science. 16, 1, 9.

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122 引文斯高帕斯（Scopus）

Triflavin, an αiIβ3 disintegrin, inhibits cell adhesion and protein kinase C-α translocation in vascular smooth muscle cells

Wu, C. J., Hsieh, C. Y., Hsiao, G., Chou, D. S. & Sheu, J. R., 10月 2009, 於: Pharmaceutical Biology. 47, 10, p. 948-954 7 p.

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2007

Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: An ESR study

Chou, D. S., Lee, J. J., Hsiao, G., Hsieh, C. Y., Tsai, Y. J., Chen, T.-F. & Sheu, J. R., 2月 7 2007, 於: Journal of Agricultural and Food Chemistry. 55, 3, p. 649-655 7 p.

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27 引文斯高帕斯（Scopus）

謝 政穎

研究成果

搜尋結果

謝政穎