Alexander TH Wu

2024

Alterações dos parâmetros bioquímicos séricos e fosforilação da tirosina em rim e fígado de ratos induzidos por estresse crônico

Khanthiyong, B., Arun, S., Bunsueb, S., Thongbuakaew, T., Suwannakhan, A., Tsang-Hsien Wu, A., Iamsaard, S. & Chaiyamoon, A., 2024, 於: Brazilian Journal of Biology. 84, e254646.

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2023

In silico study of novel niclosamide derivatives, SARS-CoV-2 nonstructural proteins catalytic residue-targeting small molecules drug candidates

Lawal, B., Tsai, S. K., Wu, A. T. H. & Huang, H. S., 5月 2023, 於: Arabian Journal of Chemistry. 16, 5, 104654.

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Multiomics Study of a Novel Naturally Derived Small Molecule, NSC772864, as a Potential Inhibitor of Proto-Oncogenes Regulating Cell Cycle Progression in Colorectal Cancer

Mokgautsi, N., Kuo, Y. C., Chen, C. H., Huang, Y. J., Wu, A. T. H. & Huang, H. S., 1月 2023, 於: Cells. 12, 2, 340.

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Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK/Akt-mTOR signaling axis

Chen, M. Y., Hsu, C. H., Setiawan, S. A., Tzeng, D. T. W., Ma, H. P., Ong, J. R., Chu, Y. C., Hsieh, M. S., Wu, A. T. H., Tzeng, Y. M. & Yeh, C. T., 1月 2023, 於: Phytomedicine. 108, 154478.

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1 引文斯高帕斯（Scopus）

Preclinical Evaluation of a Novel Small Molecule LCC-21 to Suppress Colorectal Cancer Malignancy by Inhibiting Angiogenic and Metastatic Signatures

Mokgautsi, N., Kuo, Y. C., Huang, Y. J., Chen, C. H., Mukhopadhyay, D., Wu, A. T. H. & Huang, H. S., 1月 2023, 於: Cells. 12, 2, 266.

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Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways

Hsu, C. H., Weng, P. W., Chen, M. Y., Yeh, C. T., Setiawan, S. A., Yadav, V. K., Wu, A. T. H., Tzeng, D. T. W., Gong, J. X., Yang, Z. & Tzeng, Y. M., 1月 2023, 於: Chemico-Biological Interactions. 370, 110329.

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2022

Anticancer Activities of 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinolin-11-one (SJ10) in Glioblastoma Multiforme (GBM) Chemoradioresistant Cell Cycle-Related Oncogenic Signatures

Mokgautsi, N., Kuo, Y. C., Tang, S. L., Liu, F. C., Chen, S. J., Wu, A. T. H. & Huang, H. S., 1月 1 2022, 於: Cancers. 14, 1, 262.

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2 引文斯高帕斯（Scopus）

Atypical Teratoid/Rhabdoid Tumor in Taiwan: A Nationwide, Population-Based Study

Liu, Y. L., Tsai, M. L., Chen, C. I., Yar, N., Tsai, C. W., Lee, H. L., Kuo, C. C., Ho, W. L., Hsieh, K. L. C., Tseng, S. H., Miser, J. S., Chang, C. Y., Chang, H., Huang, W. C., Wong, T. T., Wu, A. T. H. & Yen, Y. C., 2月 1 2022, 於: Cancers. 14, 3, 668.

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5 引文斯高帕斯（Scopus）

Biochemical and tissue physiopathological evaluation of the preclinical efficacy of Solanum torvum Swartz leaves for treating oxidative impairment in rats administered a β-cell-toxicant (STZ)

Sani, S., Lawal, B., Ejeje, J. N., Aliu, T. B., Onikanni, A. S., Uchewa, O. O., Ovoh, J. C., Ekpa, F. U., Ozoagu, C. D., Akuma, T. S., Onyeji, S. C., Obialor, A., Alotaibi, S. S., Albogami, S. M., De Waard, M., Batiha, G. E. S., Huang, T. H. & Wu, A. T. H., 10月 2022, 於: Biomedicine and Pharmacotherapy. 154, 113605.

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Gamma-mangostin isolated from garcinia mangostana suppresses colon carcinogenesis and stemness by downregulating the GSK3β/β-catenin/CDK6 cancer stem pathway

Wu, A. TH., Yeh, Y. C., Huang, Y. J., Mokgautsi, N., Lawal, B. & Huang, T. H., 1月 2022, 於: Phytomedicine. 95, 153797.

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4 引文斯高帕斯（Scopus）

Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone

Lawal, B., Kuo, Y. C., Rachmawati Sumitra, M., Wu, A. T. H. & Huang, H. S., 9月 2022, 於: Computers in Biology and Medicine. 148, 105814.

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4 引文斯高帕斯（Scopus）

Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative

Wu, A. T. H., Lawal, B., Tzeng, Y. M., Shih, C. C. & Shih, C. M., 2月 1 2022, 於: International journal of molecular sciences. 23, 3, 1281.

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7 引文斯高帕斯（Scopus）

Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin

Cheng, S. Y., Wu, A. T. H., Batiha, G. E. S., Ho, C. L., Lee, J. C., Lukman, H. Y., Alorabi, M., Alrasheedi, A. N. & Chen, J. H., 2月 2022, 於: Biology. 11, 2, 324.

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1 引文斯高帕斯（Scopus）

Large-scale transcriptomic analysis of coding and non-coding pathological biomarkers, associated with the tumor immune microenvironment of thyroid cancer and potential target therapy exploration

Shih, M. L., Lawal, B., Cheng, S. Y., Olugbodi, J. O., Babalghith, A. O., Ho, C. L., Cavalu, S., Batiha, G. E. S., Albogami, S., Alotaibi, S. S., Lee, J. C. & Wu, A. T. H., 8月 2022, 於: Frontiers in Cell and Developmental Biology. 10, 923503.

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2 引文斯高帕斯（Scopus）

Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule

Lawal, B., Wu, A. T. H. & Huang, H. S., 5月 2022, 於: Frontiers in Immunology. 13, 872470.

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4 引文斯高帕斯（Scopus）

Luteolin-Rich Extract of Thespesia garckeana F. Hoffm. (Snot Apple) Contains Potential Drug-Like Candidates and Modulates Glycemic and Oxidoinflammatory Aberrations in Experimental Animals

Alozieuwa, U. B., Lawal, B., Sani, S., Onikanni, A. S., Osuji, O., Ibrahim, Y. O., Babalola, S. B., Mostafa-Hedeab, G., Alsayegh, A. A., Albogami, S., Batiha, G. E. S., Wu, A. T. H., Huang, H. S. & Conte-Junior, C. A., 2022, 於: Oxidative Medicine and Cellular Longevity. 2022, 1215097.

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5 引文斯高帕斯（Scopus）

Preclinical anti-inflammatory and antioxidant effects of Azanza garckeana in STZ-induced glycemic-impaired rats, and pharmacoinformatics of it major phytoconstituents

Lawal, B., Sani, S., Onikanni, A. S., Ibrahim, Y. O., Agboola, A. R., Lukman, H. Y., Olawale, F., Jigam, A. A., Batiha, G. E. S., Babalola, S. B., Mostafa-Hedeab, G., Lima, C. M. G., Wu, A. T. H., Huang, H. S. & Conte-Junior, C. A., 8月 2022, 於: Biomedicine and Pharmacotherapy. 152, 113196.

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9 引文斯高帕斯（Scopus）

Protective effects of Thai Mucuna pruriens (L.) DC. var. pruriens seeds on sexual behaviors and essential reproductive markers in chronic unpredictable mild stress mice

Choowong-in, P., Sattayasai, J., Boonchoong, P., Poodendaen, C., Wu, A. TH., Tangsrisakda, N., Sawatpanich, T., Arun, S., Uabundit, N. & Iamsaard, S., 7月 2022, 於: Journal of Traditional and Complementary Medicine. 12, 4, p. 402-413 12 p.

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2 引文斯高帕斯（Scopus）

Seed extract of Thai Mucuna pruriens (L.) DC. var. pruriens enhances sexual performance and improves male reproductive damages in ethanol-induced rats

Tangsrisakda, N., Kamollerd, T., Taoto, C., Bunsueb, S., Chaimontri, C., Choowong-In, P., Lapyuneyong, N., Wu, A. TH., Thukhammee, W., Wattanathorn, J., Arun, S., Sawatpanich, T. & Iamsaard, S., 6月 28 2022, 於: Journal of Ethnopharmacology. 292, 115219.

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1 引文斯高帕斯（Scopus）

Seed extract of Thai Mucuna pruriens reduced male reproductive damage in rats induced by chronic stress

Lapyuneyong, N., Tangsrisakda, N., Choowong-In, P., Chaisiwamongkol, K., Uabundit, N., Sawatpanich, T., Arun, S., Wu, A. T. H. & Iamsaard, S., 2022, 於: Pharmaceutical Biology. 60, 1, p. 374-383 10 p.

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2 引文斯高帕斯（Scopus）

Transcriptomic discovery of a theranostic signature (SERPINE1/MMP3/COL1A1/SPP1) for head and neck squamous cell carcinomas and identification of antrocinol as a candidate drug

Shih, M. L., Lee, J. C., Cheng, S. Y., Lawal, B., Ho, C. L., Wu, C. C., Tzeng, D. T. W., Chen, J. H. & Wu, A. T. H., 11月 2022, 於: Computers in Biology and Medicine. 150, 106185.

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1 引文斯高帕斯（Scopus）

2021

An integrated bioinformatics study of a novel niclosamide derivative, nsc765689, a potential gsk3β/β-catenin /stat3/ cd44 suppressor with anti-glioblastoma properties

Mokgautsi, N., Wen, Y. T., Lawal, B., Khedkar, H., Sumitra, M. R., Wu, A. T. H. & Huang, H. S., 3月 1 2021, 於: International journal of molecular sciences. 22, 5, p. 1-23 23 p., 2464.

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14 引文斯高帕斯（Scopus）

A preclinical investigation of gbm-n019 as a potential inhibitor of glioblastoma via exosomal mtor/cdk6/stat3 signaling

Wu, A. T. H., Huang, H. S., Wen, Y. T., Lawal, B., Mokgautsi, N., Huynh, T. T., Hsiao, M. & Wei, L., 9月 11 2021, 於: Cells. 10, 9, 2391.

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2 引文斯高帕斯（Scopus）

Bc-n102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at g1/g0 phase

Lawal, B., Kuo, Y. C., Wu, A. T. H. & Huang, H. S., 2021, 於: International Journal of Biological Sciences. 17, 12, p. 3224-3238 15 p.

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12 引文斯高帕斯（Scopus）

Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma

Yeh, C. T., Chen, T. T., Satriyo, P. B., Wang, C. H., Wu, A. T. H., Chao, T. Y., Lee, K. Y., Hsiao, M., Wang, L. S. & Kuo, K. T., 7月 2021, 於: Oncogenesis. 10, 7, 56.

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3 引文斯高帕斯（Scopus）

Chronic stress affects tyrosine phosphorylated protein expression and secretion of male rat epididymis

Arun, S., Chaiyamoon, A., Lapyuneyong, N., Bunsueb, S., Wu, A. T. H. & Iamsaard, S., 4月 2021, 於: Andrologia. 53, 3, e13981.

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7 引文斯高帕斯（Scopus）

Comprehensive omics analysis of a novel small-molecule inhibitor of chemoresistant oncogenic signatures in colorectal cancer cell with antitumor effects

Huang, T. H., Mokgautsi, N., Huang, Y. J., Wu, A. T. H. & Huang, H. S., 8月 2021, 於: Cells. 10, 8, 1970.

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6 引文斯高帕斯（Scopus）

Effect of chronic stress on expression and secretion of seminal vesicle proteins in adult rats

Iamsaard, S., Tongpan, S., Yannasithinon, S., Arun, S., Wu, A. T. H. & Sukhorum, W., 2月 2021, 於: Andrologia. 53, 1, e13800.

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10 引文斯高帕斯（Scopus）

Identification of cancer hub gene signatures associated with immune-suppressive tumor microenvironment and ovatodiolide as a potential cancer immunotherapeutic agent

Chen, J. H., Wu, A. T. H., Lawal, B., Tzeng, D. T. W., Lee, J. C., Ho, C. L. & Chao, T. Y., 8月 1 2021, 於: Cancers. 13, 15, 3847.

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20 引文斯高帕斯（Scopus）

In-silico evaluation of genetic alterations in ovarian carcinoma and therapeutic efficacy of nsc777201, as a novel multi-target agent for ttk, nek2, and cdk1

Khedkar, H. N., Wang, Y. C., Yadav, V. K., Srivastava, P., Lawal, B., Mokgautsi, N., Sumitra, M. R., Wu, A. T. H. & Huang, H. S., 6月 2021, 於: International journal of molecular sciences. 22, 11, 5895.

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5 引文斯高帕斯（Scopus）

In vivo pharmacokinetic and anticancer studies of hh-n25, a selective inhibitor of topoisomerase i, and hormonal signaling for treating breast cancer

Lawal, B., Kuo, Y. C., Sumitra, M. R., Wu, A. T. H. & Huang, H. S., 2021, 於: Journal of Inflammation Research. 14, p. 4901-4913 13 p.

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17 引文斯高帕斯（Scopus）

Lcc-09, a novel salicylanilide derivative, exerts anti-inflammatory effect in vascular endothelial cells

Angom, R. S., Zhu, J., Wu, A. T. H., Sumitra, M. R., Pham, V., Dutta, S., Wang, E., Madamsetty, V. S., Perez-Cordero, G. D., Huang, H. S., Mukhopadhyay, D. & Wang, Y., 2021, 於: Journal of Inflammation Research. 14, p. 4551-4565 15 p.

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2 引文斯高帕斯（Scopus）

mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2′,4′-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications

Lawal, B., Lee, C-Y., Mokgautsi, N., Sumitra, M. R., Khedkar, H., Wu, A. T. H. & Huang, H-S., 3月 26 2021, 於: Frontiers in Oncology. 11, p. 656738 656738.

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35 引文斯高帕斯（Scopus）

Multi‐omics data analysis of gene expressions and alterations, cancer‐associated fibroblast and immune infiltrations, reveals the onco‐immune prognostic relevance of stat3/cdk2/4/6 in human malignancies

Lawal, B., Lin, L. C., Lee, J. C., Chen, J. H., Bekaii‐saab, T. S., Wu, A. T. H. & Ho, C. L., 3月 1 2021, 於: Cancers. 13, 5, p. 1-26 26 p., 954.

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27 引文斯高帕斯（Scopus）

Multiomics identification of potential targets for alzheimer disease and antrocin as a therapeutic candidate

Wu, A. T. H., Lawal, B., Wei, L., Wen, Y. T., Tzeng, D. T. W. & Lo, W. C., 10月 2021, 於: Pharmaceutics. 13, 10, 1555.

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14 引文斯高帕斯（Scopus）

MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types

Wu, S. Y., Lin, K. C., Lawal, B., Wu, A. T. H. & Wu, C. Z., 1月 2021, 於: Computational and Structural Biotechnology Journal. 19, p. 4970-4983 14 p.

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23 引文斯高帕斯（Scopus）

Network pharmacological analysis through a bioinformatics approach of novel nsc765600 and nsc765691 compounds as potential inhibitors of ccnd1/cdk4/plk1/cd44 in cancer types

Mokgautsi, N., Wang, Y. C., Lawal, B., Khedkar, H., Sumitra, M. R., Wu, A. T. H. & Huang, H. S., 6月 2021, 於: Cancers. 13, 11, 2523.

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10 引文斯高帕斯（Scopus）

Nsc828779 alleviates renal tubulointerstitial lesions involving interleukin-36 signaling in mice

Yang, S. R., Hung, S. C., Chu, L. J., Hua, K. F., Wei, C. W., Tsai, I. L., Kao, C. C., Sung, C. C., Chu, P., Wu, C. Y., Chen, A., Wu, A. T. H., Liu, F. C., Huang, H. S. & Ka, S. M., 11月 2021, 於: Cells. 10, 11, 3060.

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1 引文斯高帕斯（Scopus）

Pan‐cancer analysis of immune complement signature c3/c5/c3ar1/c5ar1 in association with tumor immune evasion and therapy resistance

Lawal, B., Tseng, S. H., Olugbodi, J. O., Iamsaard, S., Ilesanmi, O. B., Mahmoud, M. H., Ahmed, S. H., Batiha, G. E. S. & Wu, A. T. H., 8月 2 2021, 於: Cancers. 13, 16, 4124.

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14 引文斯高帕斯（Scopus）

Pharmacoinformatics and preclinical studies of nsc765690 and nsc765599, potential stat3/cdk2/4/6 inhibitors with antitumor activities against nci60 human tumor cell lines

Lawal, B., Liu, Y. L., Mokgautsi, N., Khedkar, H., Sumitra, M. R., Wu, A. T. H. & Huang, H. S., 2021, 於: Biomedicines. 9, 1, p. 1-22 22 p., 92.

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34 引文斯高帕斯（Scopus）

Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives

Lawal, B., Wang, Y. C., Wu, A. T. H. & Huang, H. S., 8月 27 2021, 於: Frontiers in Pharmacology. 12, 691234.

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16 引文斯高帕斯（Scopus）

Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment

Onikanni, A. S., Lawal, B., Olusola, A. O., Olugbodi, J. O., Sani, S., Ajiboye, B. O., Ilesanmi, O. B., Alqarni, M., Mostafahedeab, G., Obaidullah, A. J., Batiha, G. E. S. & Wu, A. T. H., 2021, 於: Journal of Inflammation Research. 14, p. 6749-6764 16 p.

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12 引文斯高帕斯（Scopus）

Structure-based strategies for synthesis, lead optimization and biological evaluation of N-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as potential multi-target anticancer agents

Ali, A. A. A., Lee, Y. R., Wu, A. T. H., Yadav, V. K., Yu, D. S. & Huang, H. S., 2月 2021, 於: Arabian Journal of Chemistry. 14, 2, 102884.

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8 引文斯高帕斯（Scopus）

The effect of Dolichandrone serrulata (wall. ex DC.) Seem. flower extract containing antioxidant capacity and terpenoids on the male reproductive system

Chaimontri, C., Arun, S., Sawatpanich, T., Yannasithinon, S., Tangsrisakda, N., Bunsueb, S., Wu, A. T. H. & Iamsaard, S., 4月 2021, 於: Andrologia. 53, 3, e13966.

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6 引文斯高帕斯（Scopus）

Thrombus-specific theranostic nanocomposite for codelivery of thrombolytic drug, algae-derived anticoagulant and NIR fluorescent contrast agent

Chang, L. H., Chuang, E. Y., Cheng, T. M., Lin, C., Shih, C. M., Wu, A. TH., Jheng, P. R., Lu, H. Y., Shih, C. C. & Mi, F. L., 2021, 於: Acta Biomaterialia. 134, p. 686-701 16 p.

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11 引文斯高帕斯（Scopus）

Transcriptomic-based identification of the immuno-oncogenic signature of cholangiocarcinoma for hlc-018 multi-target therapy exploration

Lawal, B., Kuo, Y. C., Tang, S. L., Liu, F. C., Wu, A. T. H., Lin, H. Y. & Huang, H. S., 11月 2021, 於: Cells. 10, 11, 2873.

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14 引文斯高帕斯（Scopus）

2020

Assessment of Predictive Scoring System for 90-Day Mortality Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Completed Concurrent Chemoradiotherapy

Lin, K. C., Chen, T. M., Yuan, K. S. P., Wu, A. T. H. & Wu, S. Y., 3月 2 2020, 於: JAMA network open. 3, 3, p. e1920671

研究成果: 雜誌貢獻 › 文章 › 同行評審

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20 引文斯高帕斯（Scopus）

Biomechanical comparison of four tibial fixation techniques for meniscal root sutures in posterior medial meniscus root repair: A porcine study

Wu, S. H., Yeh, T. T., Hsu, W. C., Wu, A. T. H., Li, G., Chen, C. H., Lee, C. H. & Wu, J. L., 9月 1 2020, 於: Journal of Orthopaedic Translation. 24, p. 144-149 6 p.

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3 引文斯高帕斯（Scopus）

Galectin-3 modulates macrophage activation and contributes smooth muscle cells apoptosis in abdominal aortic aneurysm pathogenesis

Lu, H. Y., Shih, C. M., Huang, C. Y., Wu, A. T. H., Cheng, T. M., Mi, F. L. & Shih, C. C., 11月 1 2020, 於: International journal of molecular sciences. 21, 21, p. 1-15 15 p., 8257.

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4 引文斯高帕斯（Scopus）

Hnc0014, a multi-targeted small-molecule, inhibits head and neck squamous cell carcinoma by suppressing c-met/stat3/cd44/pd-l1 oncoimmune signature and eliciting antitumor immune responses

Lee, J. C., Wu, A. T. H., Chen, J. H., Huang, W. Y., Lawal, B., Mokgautsi, N., Huang, H. S. & Ho, C. L., 12月 2020, 於: Cancers. 12, 12, p. 1-18 18 p., 3759.

研究成果: 雜誌貢獻 › 文章 › 同行評審

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19 引文斯高帕斯（Scopus）

吳 駿翃

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吳駿翃