生藥學研究所

2024

An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors

Lin, T. E., Yen, D., HuangFu, W. C., Wu, Y. W., Hsu, J. Y., Yen, S. C., Sung, T. Y., Hsieh, J. H., Pan, S. L., Yang, C. R., Huang, W. J. & Hsu, K. C., 6月 2024, 於: Protein Science. 33, 6, e5007.

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A new sterol from the Formosan soft coral Lobophytum durum

Hung, C. L., Huang, L. C., Shih, K. Y., Lai, K. H., Peng, B. R., Hwang, T. L., Chien, S. Y., Li, C. Y. & Chung, H. M., 1月 15 2024, 於: Journal of Molecular Structure. 1296, 136790.

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A New Sterol-Related Metabolite from the Soft Coral Capnella imbricata

Tsai, Z. Z., Hsu, C. K., Chen, P. J., Chen, Y. L., Chien, S. Y., Wen, Z. H., Sung, P. J., Lai, K. H. & Chung, H. M., 5月 1 2024, 於: Records of Natural Products. 18, 3, p. 357-362 6 p.

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Anti-inflammatory constituents from a sea anemone-derived fungus Arthrinium arundinis MA30

Lee, Y. S., Wu, H. C., Huang, S. J., Hsiao, G., Chi, W. C. & Lee, T. H., 3月 2024, 於: Phytochemistry. 219, 113998.

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Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats

Shi, B., Lin, C. C., Lee, C. J., Ning, D. S., Lin, C. C., Zhao, H. W., Yang, C. S., Deng, S. X., Chiu, Y. J. & Wang, C. C., 2024, 於: Frontiers in Pharmacology. 15, 1326415.

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A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies

Kao, M.-R., Ma, T.-H., Chou, H.-Y., Chang, S.-C., Cheng, L.-C., Liao, K.-S., Shie, J.-J., Harris, P. J., Wong, C.-H. & Hsieh, Y. S. Y., 7月 19 2024, 於: ACS Chemical Biology. 19, 7, p. 1515-1524 10 p.

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Artemisia monosperma essential oil nanoformulations alleviate imiquimod-induced psoriasis-like dermatitis in mice

Tawfik, N. F., Abdel-Rashid, R. S., El-Sayed, E. K., Abdel-moneum, R., Khattab, M. A., Ahmed, A. A., Lai, K. H., Hashad, N. & Moharram, F. A., 9月 30 2024, 於: International Immunopharmacology. 139, 112733.

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Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

Cheng, T. Y., Yang, C. J., Chen, P. J., Chen, Y. L., Peng, B. R., Kung, T. A., Wen, Z. H., Lai, K. H. & Chung, H. M., 6月 2024, 於: Phytochemistry Letters. 61, p. 115-119 5 p.

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Characteristics and Effects of Chinese Herbal Medicine in the Management of Female Infertility: A Hospital-Based Study

Chou, P. Y., Chen, C. M., Wang, C. C., Tai, C. J., Lin, Y. K. & Tang, Y. J., 1月 1 2024, 於: Complementary Medicine Research. 30, 6, p. 481-491 11 p.

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Chronopharmacology of diuresis via metabolic profiling and key biomarker discovery of the traditional Chinese prescription Ji-Ming-San using tandem mass spectrometry in rat models

Hsieh, C. Y., Tsai, P. W., Tomioka, Y., Matsumoto, Y., Akiyama, Y., Wang, C. C., Tayo, L. L. & Lee, C. J., 2月 2024, 於: Phytomedicine. 124, 155260.

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Evaluating the effects of surfactant types on the properties and stability of oil-in-water Rhodiola rosea nanoemulsion

Iskandar, B., Mei, H. C., Liu, T. W., Lin, H. M. & Lee, C. K., 2月 2024, 於: Colloids and Surfaces B: Biointerfaces. 234, 113692.

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Exploring anti-inflammatory non-essential oil metabolites in Mentha canadensis: Insights into neutrophil extracellular trap inhibition for functional health promotion

Le, H. G., Chen, Y. S., Cheng, T. P., Tsai, Y. F., Chen, P. J., Cheng, W. C., El-Shazly, M., Chang, Y. C., Hwang, T. L. & Lai, K. H., 6月 2024, 於: Journal of Functional Foods. 117, 106233.

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1 引文斯高帕斯（Scopus）

Exploring the wound-healing potential and seasonal chemical variability of the Formosan Callery pear Pyrus calleryana: implications for therapeutic applications

Peng, B. R., Tang, X. Y., Chen, Y. S., Lai, K. H. & Lee, M. H., 2024, 於: Pharmaceutical Biology. 62, 1, p. 621-633 13 p.

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Flexible nanohybrid substrates utilizing gold nanocubes/nano mica platelets with 3D lightning-rod effect for highly efficient bacterial biosensors based on surface-enhanced Raman scattering

Chen, Y. F., Lu, M. C., Lee, C. J. & Chiu, C. W., 2024, (接受/付印) 於: Journal of Materials Chemistry B.

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1 引文斯高帕斯（Scopus）

Hypermethylation of the Gene Body in SRCIN1 Is Involved in Breast Cancer Cell Proliferation and Is a Potential Blood-Based Biomarker for Early Detection and a Poor Prognosis

Shen, H. T., Hung, C. S., Davis, C., Su, C. M., Liao, L. M., Shih, H. M., Lee, K. D., Ansar, M. & Lin, R. K., 5月 2024, 於: Biomolecules. 14, 5, 571.

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Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells

Tran, H. L., Lai, K. H., Chang, H. S., Chen, Y. S., Wang, H. C., Yang, S. S., Chang, H. W., Hsu, C. M., Yen, C. H. & Hsiao, H. H., 12月 2024, 於: BMC Complementary Medicine and Therapies. 24, 1, 28.

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Inequality relations for NMR-based polymer homoblock analysis and extended application: Reanalysis of historical data on alginates, chitosans, homogalacturonans, and galactomannans

Xing, X., Xing, K., Hsieh, Y. S. Y. & Abbott, D. W., 8月 2024, 於: Carbohydrate Research. 542, 109189.

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Is the CslF6 gene involved in the accumulation of (1,3;1,4)-β-D-glucan in wheats, their wild relatives and their hybrids?

Marcotuli, I., Xing, X., Caranfa, D., Giove, S. L., Hsieh, Y. S. Y., Chang, S.-C., Wade Abbott, D. & Gadaleta, A., 7月 2024, 於: Food Chemistry: Molecular Sciences.

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Phenolic profiling and bioactivity assessment of in vitro propagated Psidium cattleianum Sabine: A promising study

El-Deeb, E. M., Elsayed, H. E., Ateya, H. B., Taha, H. S., Elgindi, M. R., Abouelenein, D., Caprioli, G., Lai, K. H., Mustafa, A. M. & Moharram, F. A., 4月 30 2024, 於: Heliyon. 10, 8, e29379.

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Polymethoxyflavone from Citrus depressa as an inhibitor against various variants of SARS-CoV-2 spike protein

Liu, T.-W., Hsu, S.-J., Hsieh, Y. S. Y., Liu, H.-K. & Lee, C.-K., 2月 10 2024, 於: Journal of Ethnopharmacology. 320, p. 117412 117412.

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1 引文斯高帕斯（Scopus）

Spermatozoon-propelled microcellular submarines combining innate magnetic hyperthermia with derived nanotherapies for thrombolysis and ischemia mitigation

Weng, P.-W., Liu, C.-H., Jheng, P.-R., Chiang, C.-C., Chen, Y.-T., Rethi, L., Hsieh, Y. S. Y. & Chuang, A.E.-Y., 8月 2024, 於: Journal of Nanobiotechnology. 22, 1

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Substrate Specificities of Variants of Barley (1,3)- and (1,3;1,4)-β-d-Glucanases Resulting from Mutagenesis and Segment Hybridization

Kao, M. R., Jake , P., Daniel, O., Chang, S. C., Cheng, L. C., Wang, D., Srivastava, V., Wagner, J. E., Harris, P. J. & Hsieh, Y., 4月 10 2024, 於: Biochemistry.

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The knowns and unknowns of callose biosynthesis in terrestrial plants

Hsieh, Y. S. Y., Kao, M.-R. & Tucker, M. R., 4月 2024, 於: Carbohydrate Research. 538, 109103.

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1 引文斯高帕斯（Scopus）

Two glycosyl transferase 2 genes from the gram-positive bacterium Clostridium ventriculi encode (1,3;1,4)-β-D-glucan synthases

Chang, S.-C., Karmakar Saldivar, R., Kao, M.-R., Xing, X., Yeh, C.-H., Shie, J.-J., Abbott, D. W., Harris, P. J. & Hsieh, Y. S. Y., 2024, 於: Carbohydrate Polymers. 342

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Xanthine oxidase inhibition study of isolated secondary metabolites from Dolichandrone spathacea (Bignoniaceae): In vitro and in silico approach

Nguyen, D. K., Liu, T. W., Hsu, S. J., Huynh, Q. D. T., Thi Duong, T. L., Chu, M. H., Wang, Y. H., Vo, T. H. & Lee, C. K., 4月 2024, 於: Saudi Pharmaceutical Journal. 32, 4, 101980.

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2023

Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer’s disease

Sanotra, M. R., Kao, S. H., Lee, C. K., Hsu, C. H., Huang, W. C., Chang, T. C., Tu, F. Y., Hsu, I. U. & Lin, Y. F., 12月 2023, 於: Alzheimer's Research and Therapy. 15, 1, 115.

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5 引文斯高帕斯（Scopus）

A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway

Lin, S. Y., Oakley, C. E., Jenkinson, C. B., Chiang, Y. M., Lee, C. K., Jones, C. G., Seidler, P. M., Nelson, H. M., Todd, R. B., Wang, C. C. C. & Oakley, B. R., 2023, (接受/付印) 於: Chemical Science. 14, 40, p. 11022-11032 11 p.

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4 引文斯高帕斯（Scopus）

A new capnellene skeleton from the octocoral Capnella imbricata (Quoy & Gaimard, 1833)

Wu, I. T., Fan, Y. C., Lin, G. Z., Wang, Y. L., Hwang, T. L., Lai, K. H. & Chung, H. M., 1月 2023, 於: Journal of Molecular Structure. 1271, 133995.

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2 引文斯高帕斯（Scopus）

An integrative approach for compressive quality control of RespireAid™, a traditional Chinese medicine formula against SARS-CoV-2

Wang, K. T., Lee, C. J., Lee, M. C., Chen, C. Y., Tsai, Y. C. & Chuang, W. C., 2023, 於: Journal of Food and Drug Analysis. 31, 3, p. 473-484 12 p., 7.

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A non-genetic engineering platform for rapidly generating and expanding cancer-specific armed T cells

Chen, Y. J., Chen, M., Cheng, T. L., Tsai, Y. S., Wang, C. H., Chen, C. Y., Wu, T. Y., Tzou, S. C., Wang, K. H., Cheng, J. J., Kao, A. P., Lin, S. Y. & Chuang, K. H., 12月 2023, 於: Journal of Biomedical Science. 30, 1, 35.

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2 引文斯高帕斯（Scopus）

Anti-Aging Constituents from Pinus morrisonicola Leaves

Liu, T. W., Hsiao, S. W., Lin, C. T., Hsiao, G. & Lee, C. K., 7月 2023, 於: Molecules. 28, 13, 5063.

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Anti-COVID-19, Anti-Inflammatory, and Anti-Osteoarthritis Activities of Sesamin from Sesamum indicum L.

Huang, S. M., Hsieh, C. Y., Ting, J. U., De Castro-Cruz, K. A., Wang, C. C., Lee, C. J. & Tsai, P. W., 11月 2023, 於: Bioengineering. 10, 11, 1263.

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Antihyperglycemic and Anti-inflammatory Activities of Traditional Philippine Herbal Formula (Pito-pito)

Ramos, J. L. T., Hsieh, C. Y., Lee, C. J., De Castro-Cruz, K. A. & Tsai, P. W., 2023, 於: Biointerface Research in Applied Chemistry. 13, 1, 99.

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Anti-inflammatory and antiviral activities of flavone C-glycosides of Lophatherum gracile for COVID-19

Chen, Y. L., Chen, C. Y., Lai, K. H., Chang, Y. C. & Hwang, T. L., 2月 2023, 於: Journal of Functional Foods. 101, 105407.

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9 引文斯高帕斯（Scopus）

Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis

Kung, T. A., Chen, L. Y., Li, C. Y., Peng, B. R., Hwang, T. L., Sung, P. J., Lai, K. H. & Chung, H. M., 6月 2023, 於: Phytochemistry Letters. 55, p. 12-16 5 p.

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Assessing the skin-whitening property of plant extracts from taiwanese species using zebrafish as a rapid screening platform

Hsiao, S. W., Kuo, I. C., Syu, L. L., Lee, T. H., Cheng, C. H., Mei, H. C. & Lee, C. K., 9月 2023, 於: Arabian Journal of Chemistry. 16, 9, 105035.

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3 引文斯高帕斯（Scopus）

Biological Properties and Phytonutrient Profile of Beans: Vigna angularis, Vigna radiata, and Glycine max

Hsieh, C. Y., Tsai, J. R., Lee, C. J., Ciou, Y. R., Li, J. S., Tayo, L. L. & Tsai, P. W., 2月 15 2023, 於: Biointerface Research in Applied Chemistry. 13, 1, 53.

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3 引文斯高帕斯（Scopus）

Biomimetic Platelet Nanomotors for Site-Specific Thrombolysis and Ischemic Injury Alleviation

Chen, Y.-T., Liu, C.-H., Pan, W.-Y., Jheng, P.-R., Hsieh, Y. S. Y., Burnouf, T., Fan, Y.-J., Chiang, C.-C., Chen, T.-Y. & Chuang, E.-Y., 7月 12 2023, 於: ACS applied materials & interfaces.

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10 引文斯高帕斯（Scopus）

Capnellenes from Capnella imbricata: Deciphering Their Anti-Inflammatory-Associated Chemical Features

Lai, K. H., Fan, Y. C., Peng, B. R., Wen, Z. H. & Chung, H. M., 7月 2023, 於: Pharmaceuticals. 16, 7, 916.

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2 引文斯高帕斯（Scopus）

Chemical Constituents and Bioactive Principles from the Mexican Truffle and Fermented Products of the Derived Fungus Ustilago maydis MZ496986

Wu, H. C., His, H. Y., Hsiao, G., Yen, C. H., Leu, J. Y., Wu, C. C., Chang, S. H., Huang, S. J. & Lee, T. H., 1月 18 2023, 於: Journal of Agricultural and Food Chemistry. 71, 2, p. 1122-1131 10 p.

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4 引文斯高帕斯（Scopus）

Chemical investigations and cytotoxic effects of metabolites from Antrodia camphorata against human hepatocellular carcinoma cells

Chen, Y. F., Wu, H. C., Chang, J. M., Ko, H. H., Lin, C. H. & Chang, H. S., 2023, 於: Natural Product Research. 37, 4, p. 560-570 11 p.

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3 引文斯高帕斯（Scopus）

Chemometric-guided chemical marker selection: A case study of the heat-clearing herb Scrophularia ningpoensis

Wang, L. S., Chen, P. J., Cheng, W. C., Chang, Y. C., El-Shazly, M., Chen, L. Y., Peng, B. R., Su, C. H., Yen, P. T., Hwang, T. L. & Lai, K. H., 3月 2023, 於: Frontiers in Plant Science. 14, 1153710.

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3 引文斯高帕斯（Scopus）

Chemopreventive effects of Xiang Sha Liu Jun Zi Tang on paclitaxel-induced leucopenia and neuropathy in animals

Shiah, H.-S., Lee, C.-J., Lee, F.-Y., Tseng, S.-H., Chen, S.-H. & Wang, C.-C., 2023, 於: Frontiers in Pharmacology. 14

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Cinnamic aldehyde, an anti-inflammatory component in Du-Huo-Ji-Sheng-Tang, ameliorates arthritis in II collagenase and monosodium iodoacetate induced osteoarthritis rat models

Tseng, S. H., Lee, C. J., Chen, S. H., Chen, C. H., Tsai, P. W., Hsieh, M. S., Chu, J. S. & Wang, C. C., 1月 2023, 於: Journal of Traditional and Complementary Medicine. 13, 1, p. 51-61 11 p.

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3 引文斯高帕斯（Scopus）

Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice With Acute Liver Failure

Wang, C. H., Chen, C. Y., Wang, K. H., Kao, A. P., Chen, Y. J., Lin, P. H., Chen, M., Wu, T. Y., Cheng, J. J., Lee, K. D. & Chuang, K. H., 1月 30 2023, 於: Stem cells translational medicine. 12, 1, p. 39-53 15 p.

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6 引文斯高帕斯（Scopus）

Composite Hydrogels of Ultrasound-Assisted-Digested Formic Acid-Decellularized Extracellular Matrix and Sacchachitin Nanofibers Incorporated with Platelet-Rich Plasma for Diabetic Wound Treatment

Lin, C. J., Lin, H. L., You, W. C., Ho, H. O., Sheu, M. T., Chen, L. C. & Cheng, W. J., 8月 2023, 於: Journal of Functional Biomaterials. 14, 8, 423.

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1 引文斯高帕斯（Scopus）

Cucurbitacin E Exerts Anti-Proliferative Activity via Promoting p62-Dependent Apoptosis in Human Non-Small-Cell Lung Cancer A549 Cells

Hsu, H. L., Lin, B. J., Lin, Y. C., Tu, C. C., Nguyen, N. L., Wang, C. C., Chen, M. C. & Chen, C. H., 10月 2023, 於: Current Issues in Molecular Biology. 45, 10, p. 8138-8151 14 p.

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1 引文斯高帕斯（Scopus）

Design, Structure–Activity Relationships, and Enzyme Kinetic Studies of Tricyclic and Tetracyclic Coumarin–based Sulfamates as Steroid Sulfatase Inhibitors

Chiu, P.-F., Lin, I.-C., Lu, Y.-L., Chang, C.-N., Chan, H.-Y., Lin, T.-S., Tsai, K.-C., S. Y. Hsieh, Y., Chen, M.-J., Lin, M.-H. & Liang, P.-H., 9月 2023, 於: Bioorganic Chemistry. 138, 106581.

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1 引文斯高帕斯（Scopus）

Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma

Tseng, H. J., Banerjee, S., Qian, B., Lai, M. J., Wu, T. Y., Hsu, T. I., Lin, T. E., Hsu, K. C., Chuang, K. H., Liou, J. P. & Shih, J. C., 8月 2023, 於: European Journal of Medicinal Chemistry. 256, 115459.

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4 引文斯高帕斯（Scopus）

Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors

Hsu, J. Y., Hsu, K. C., Sun, C., Chou, C. H., Lin, T. E., Sung, T. Y., Tseng, H. J., Yen, S. C., Yang, C. R. & Huang, W. J., 3月 2023, 於: Biomedicine and Pharmacotherapy. 159, 114258.

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4 引文斯高帕斯（Scopus）

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