每年研究成果
每年研究成果
Description
Accession Number: GSE44827
Platform:
GPL13693: Phalanx Human OneArray® v5
Organism: Homo sapiens
Published on 2013-04-30
Summary:
Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor activated by trypsin and coagulant factors, plays broad spectrum of physiological and pathological roles especially in cancer development. In this study, we used PAR-2 activating peptide to mimic the action of trypsin to trigger PAR-2 signaling pathway and effects of PAR-2 activation on gene expression in human pancreatic cancer cell line BxPC-3 investigated by microarray analysis. Through DAVID bioinformatic resources, we observed that activated PAR-2-mediated genes are summarized to two different pathways, renal cell carcinoma and NFkB pathway. In renal cell carcinoma pathway, activated PAR-2 dysregulated hypoxia-inducible factors and its target genes, including glucose transporter 1 (GLUT1), transforming growth factor-b (TGF-b) and vascular endothelial growth factor-A (VEGF-A). In addition, activated PAR-2 induced MAPK signaling and transcriptional factors, such as JUN, MAP2K1 and ETS1. The regulation of these genes by PAR-2 assumed that PAR-2 signaling was associated with cancer progression. On the other hand, activated PAR-2 upregulated interleukin-1b (IL-1b) and toll-like receptor 4 (TLR4) related with NFkB activation, which indicated that PAR-2 signaling may cause cancer-related inflammation. In conclusion, PAR-2 may be a factor to regulate cancer progression and inflammation.
Overall Design:
Two-condition experiment, control cells vs PAR-2 AP-treated cells.
Contact:
Name: Che-Ming Teng
Organization: National Taiwan University
Deparment: Pharmacology
Address: No.1, Jen-Ai Road Taipei Taiwan
Email: [email protected]
Phone: +886-2-23123456
Name: Phalanx Biotech
Organization: Phalanx Biotech
Address: 6 Technology Road 5, 6th Floor Hsinchu Science Park Hsinchu 30077 Taiwan
Email: [email protected]
Phone: 886-3-5781168
Web-Link: http://www.onearray.com/
Platform:
GPL13693: Phalanx Human OneArray® v5
Organism: Homo sapiens
Published on 2013-04-30
Summary:
Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor activated by trypsin and coagulant factors, plays broad spectrum of physiological and pathological roles especially in cancer development. In this study, we used PAR-2 activating peptide to mimic the action of trypsin to trigger PAR-2 signaling pathway and effects of PAR-2 activation on gene expression in human pancreatic cancer cell line BxPC-3 investigated by microarray analysis. Through DAVID bioinformatic resources, we observed that activated PAR-2-mediated genes are summarized to two different pathways, renal cell carcinoma and NFkB pathway. In renal cell carcinoma pathway, activated PAR-2 dysregulated hypoxia-inducible factors and its target genes, including glucose transporter 1 (GLUT1), transforming growth factor-b (TGF-b) and vascular endothelial growth factor-A (VEGF-A). In addition, activated PAR-2 induced MAPK signaling and transcriptional factors, such as JUN, MAP2K1 and ETS1. The regulation of these genes by PAR-2 assumed that PAR-2 signaling was associated with cancer progression. On the other hand, activated PAR-2 upregulated interleukin-1b (IL-1b) and toll-like receptor 4 (TLR4) related with NFkB activation, which indicated that PAR-2 signaling may cause cancer-related inflammation. In conclusion, PAR-2 may be a factor to regulate cancer progression and inflammation.
Overall Design:
Two-condition experiment, control cells vs PAR-2 AP-treated cells.
Contact:
Name: Che-Ming Teng
Organization: National Taiwan University
Deparment: Pharmacology
Address: No.1, Jen-Ai Road Taipei Taiwan
Email: [email protected]
Phone: +886-2-23123456
Name: Phalanx Biotech
Organization: Phalanx Biotech
Address: 6 Technology Road 5, 6th Floor Hsinchu Science Park Hsinchu 30077 Taiwan
Email: [email protected]
Phone: 886-3-5781168
Web-Link: http://www.onearray.com/
| 可用日期 | 2013 |
|---|---|
| 發行者 | Gene Expression Omnibus |
研究成果
- 1 文章
-
Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-a-mediated angiogenesis
Chang, L. H., Pan, S. L., Lai, C. Y., Tsai, A. C. & Teng, C. M., 8月 2013, 於: American Journal of Pathology. 183, 2, p. 566-575 10 p.研究成果: 雜誌貢獻 › 文章 › 同行評審
開啟存取41 引文 斯高帕斯（Scopus）