Additional file 1: of Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses



Figure S1. Effect of apigenin (API) on colony formation in CL1â 5 and H1975 non-small cell lung cancer (NSCLC) cells. Figure S2. Effects of apigenin (API) on changes in different proteases in A549 and H1975 cells following 24-h treatment with API. Figure S3. Knockdown of CD26 suppresses Akt activation and the epithelial-to-mesenchymal transition (EMT) in CL1â 5 cells. Figure S4. Apigenin (API) inhibits phosphorylation of the epidermal growth factor receptor (EGFR) in EGFR-mutant HCC827 and H1975 cells. (DOCX 431 kb)