Abstract
Chronic obstructive pulmonary disease (COPD), in defined as a disease state characterized by the presence of air flow obstruction due to chronic bronchitis or emphysema, the main risk factor is smoking.
The mechanism by which cigarette smoking reduce exhaled NO is not certain, because NO itself appears to reduce the activity of iNOS (indicuble NOS), may downregulate the enzyme in cells of the respiratory tract, resulting in a reduction of exhaled NO, Increase the risk of respiratory infections.
Most of COPD patients are chronic smoker. In those chronic stable COPD patients, the level of endogenous NO deceased as FEV1 deteriorated. In those unstable or severe type of COPD patients , the sputum neutrophil increased as the airway obstruction got worse, which might induce endogenous NO production .Therefore the NO level was negatively relative to FEV1.
The mechanism by which cigarette smoking reduce exhaled NO is not certain, because NO itself appears to reduce the activity of iNOS (indicuble NOS), may downregulate the enzyme in cells of the respiratory tract, resulting in a reduction of exhaled NO, Increase the risk of respiratory infections.
Most of COPD patients are chronic smoker. In those chronic stable COPD patients, the level of endogenous NO deceased as FEV1 deteriorated. In those unstable or severe type of COPD patients , the sputum neutrophil increased as the airway obstruction got worse, which might induce endogenous NO production .Therefore the NO level was negatively relative to FEV1.
| Translated title of the contribution | Exhaled Nitric Oxide Levels in Smokers with Chronic Obstructive Pulmonary Disease |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 23-28 |
| Number of pages | 6 |
| Journal | 呼吸治療 |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2002 |
| Externally published | Yes |
Keywords
- Chronic Obstrictive Pulmonary Disease
- Nitric Oxide
- Inducible NOS