富含醯麩胺酸之全靜脈營養對維持正常老鼠小腸黏膜細胞的影響

The study was designed to investigate the effect of glutamine supplementation with different levels of caloric intake on the preservation of proximal jejunum mucosa in rats receiving total parenteral nutrition (TPN). Rats were divided into four groups; a control group was fed a chow diet and infused with saline only. Three experimental groups received TPN solutions at energy levels of 25 kcal, 30 kcal, 35 kcal / 100g body weight, respectively. The experimental groups were mintained with TPN for a period of 6 days. Each experimental group was divided into two subgroups, one of which was supplemented with glutamine, replacing 40% of the total amino acid nitrogen. All of the basal TPN solutions were insonitrogenous and identical in nutrient composition, except for the difference in energy level, which was adjusted with glucose. The results demonstrated that nitrogen retention increased in accordance with the increase of glucose supply. Howerer, no difference was observed in intestinal mucosa weight among the groups with different levels of caloric infusion. There were no differences in proximal jejunum segment and mucosa weight between subgroups with and without glutamine supplementation. It was concluded that higher nitrogen retention had no preventive effect on intestinal mucosa atrophy, and glutamine enrichment of a TPN solution did not have any effect on mucosa maintenance in normal rats.