Yes-associated protein is not an independent prognostic marker in breast cancer

Shyr Ming Sheen-Chen; Chun Ying Huang; Ching Hua Tsai; Yueh Wei Liu; Shih Chung Wu; Chao Cheng Huang; Hock Liew Eng; Yi Chia Chan; Sheung Fat Ko; Rei Ping Tang

Yes-associated protein is not an independent prognostic marker in breast cancer

Shyr Ming Sheen-Chen, Chun Ying Huang, Ching Hua Tsai, Yueh Wei Liu, Shih Chung Wu, Chao Cheng Huang, Hock Liew Eng, Yi Chia Chan, Sheung Fat Ko, Rei Ping Tang

Department of Pathology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.

Original language	English
Pages (from-to)	3321-3326
Number of pages	6
Journal	Anticancer Research
Volume	32
Issue number	8
Publication status	Published - Aug 1 2012

Keywords

Breast cancer
Tissue microarray
Yes-assosiated protein

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Yes-associated protein is not an independent prognostic marker in breast cancer",

abstract = "Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.",

keywords = "Breast cancer, Tissue microarray, Yes-assosiated protein",

author = "Sheen-Chen, {Shyr Ming} and Huang, {Chun Ying} and Tsai, {Ching Hua} and Liu, {Yueh Wei} and Wu, {Shih Chung} and Huang, {Chao Cheng} and Eng, {Hock Liew} and Chan, {Yi Chia} and Ko, {Sheung Fat} and Tang, {Rei Ping}",

year = "2012",

month = aug,

day = "1",

language = "English",

volume = "32",

pages = "3321--3326",

journal = "Anticancer Research",

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publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Yes-associated protein is not an independent prognostic marker in breast cancer

AU - Sheen-Chen, Shyr Ming

AU - Huang, Chun Ying

AU - Tsai, Ching Hua

AU - Liu, Yueh Wei

AU - Wu, Shih Chung

AU - Huang, Chao Cheng

AU - Eng, Hock Liew

AU - Chan, Yi Chia

AU - Ko, Sheung Fat

AU - Tang, Rei Ping

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.

AB - Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.

KW - Breast cancer

KW - Tissue microarray

KW - Yes-assosiated protein

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AN - SCOPUS:84865701871

SN - 0250-7005

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EP - 3326

JO - Anticancer Research

JF - Anticancer Research

IS - 8

ER -

Yes-associated protein is not an independent prognostic marker in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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