Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks

Ru Siou Hsu, Ssu Ju Li, Jen Hung Fang, I. Chi Lee, Li An Chu, Yu Chun Lo, Yu Jen Lu, You Yin Chen, Shang Hsiu Hu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Traumatic brain injury causes inflammation and glial scarring that impede brain tissue repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here we present an adaptable conductive microporous hydrogel consisting of gold nanoyarn balls-coated injectable building blocks possessing interconnected pores to improve angiogenesis and recovery of brain function in traumatic brain injury. We show that following minimally invasive implantation, the adaptable hydrogel is able to fill defects with complex shapes and regulate the traumatic brain injury environment in a mouse model. We find that placement of this injectable hydrogel at peri-trauma regions enhances mature brain-derived neurotrophic factor by 180% and improves angiogenesis by 250% in vivo within 2 weeks after electromagnetized stimulation, and that these effects facilitate neuron survival and motor function recovery by 50%. We use blood oxygenation level-dependent functional neuroimaging to reveal the successful restoration of functional brain connectivity in the corticostriatal and corticolimbic circuits.

Original languageEnglish
Article number5172
JournalNature Communications
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • brain derived neurotrophic factor
  • gold
  • gold nanoyarn ball
  • hydrogel
  • unclassified drug

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy

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