Why context matters? Divisive normalization and canonical microcircuits in psychiatric disorders

Georg Northoff, Hajime Mushiake

    Research output: Contribution to journalReview articlepeer-review

    10 Citations (Scopus)

    Abstract

    Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like schizophrenia or depression whose various symptoms can be characterized by abnormal context-dependence.

    Original languageEnglish
    Pages (from-to)130-140
    Number of pages11
    JournalNeuroscience Research
    Volume156
    DOIs
    Publication statusPublished - Jul 2020

    ASJC Scopus subject areas

    • General Neuroscience

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