TY - JOUR
T1 - What is new for an old molecule? systematic review and recommendations on the use of resveratrol
AU - Vang, Ole
AU - Ahmad, Nihal
AU - Baile, Clifton A.
AU - Baur, Joseph A.
AU - Brown, Karen
AU - Csiszar, Anna
AU - Das, Dipak K.
AU - Delmas, Dominique
AU - Gottfried, Carmem
AU - Lin, Hung Yun
AU - Ma, Qing Yong
AU - Mukhopadhyay, Partha
AU - Nalini, Namasivayam
AU - Pezzuto, John M.
AU - Richard, Tristan
AU - Shukla, Yogeshwer
AU - Surh, Young Joon
AU - Szekeres, Thomas
AU - Szkudelski, Tomasz
AU - Walle, Thomas
AU - Wu, Joseph M.
PY - 2011
Y1 - 2011
N2 - Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed "side effects" caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.
AB - Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed "side effects" caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.
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U2 - 10.1371/journal.pone.0019881
DO - 10.1371/journal.pone.0019881
M3 - Review article
C2 - 21698226
AN - SCOPUS:79959261445
SN - 1932-6203
VL - 6
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e19881
ER -
