What can different motor circuits tell us about psychosis? An RDoC perspective

Vijay A. Mittal, Jessica A. Bernard, Georg Northoff

    Research output: Contribution to journalReview articlepeer-review

    93 Citations (Scopus)


    Signs of motor dysfunction are evidenced across a range of psychiatric disorders including schizophrenia. Historically, these features have been neglected but emerging theoretical and methodological advancements have shed new light on the utility of considering movement abnormalities. Indeed, the National Institute of Mental Health Research Domain Criteria initiative has recently met to develop a Motor Systems Domain. This reflects a growing appreciation for the enhanced reliability and validity that can come along with evaluating disturbances relevant to psychiatric illnesses from multiple levels of analysis, and conceptualizing these domains with respect to the complexity of their role in a broader integrated system (ie, weighing contributions and interactions between the cognitive, affective, and motor domains). This article discusses motor behaviors and seeks to explain how research into basal ganglia, cerebellar, and cortico-motor circuit function/dysfunction, grounded in brain circuitmotor behavior relationships, can elucidate our understanding of pathophysiology, provide vital links to other key systems of interest, significantly improve identification and classification, and drive development of targeted individualized treatments.

    Original languageEnglish
    Pages (from-to)949-955
    Number of pages7
    JournalSchizophrenia bulletin
    Issue number5
    Publication statusPublished - Sept 1 2017


    • RDoC
    • basal ganglia
    • cerebellum
    • cortico-motor circuits
    • motor
    • movement abnormalities
    • psychosis
    • schizophrenia

    ASJC Scopus subject areas

    • Psychiatry and Mental health


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