TY - JOUR
T1 - What can different motor circuits tell us about psychosis? An RDoC perspective
AU - Mittal, Vijay A.
AU - Bernard, Jessica A.
AU - Northoff, Georg
N1 - Funding Information:
G.N. acknowledges financial support from Canada Research Chair (CRC), the CIHR, the Michael Smith Foundation, the University of Ottawa Brain and Mind Research Institute, the Seventh Hospital for Mental Health in Hangzhou/ China, and the National Science Foundation of China (NSF). V.A.M. is a consultant to Takeda Pharmaceuticals and no author authors have any disclosures.
Funding Information:
V.A.M. was supported by R01MH094650, R21/ R33MH103231, and R21MH110374. J.A.B. was supported in part by a Brain and Behavior Research Foundation NARSAD Young Investigator Award as the Donald and Janet Boardman Family Investigator.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Signs of motor dysfunction are evidenced across a range of psychiatric disorders including schizophrenia. Historically, these features have been neglected but emerging theoretical and methodological advancements have shed new light on the utility of considering movement abnormalities. Indeed, the National Institute of Mental Health Research Domain Criteria initiative has recently met to develop a Motor Systems Domain. This reflects a growing appreciation for the enhanced reliability and validity that can come along with evaluating disturbances relevant to psychiatric illnesses from multiple levels of analysis, and conceptualizing these domains with respect to the complexity of their role in a broader integrated system (ie, weighing contributions and interactions between the cognitive, affective, and motor domains). This article discusses motor behaviors and seeks to explain how research into basal ganglia, cerebellar, and cortico-motor circuit function/dysfunction, grounded in brain circuitmotor behavior relationships, can elucidate our understanding of pathophysiology, provide vital links to other key systems of interest, significantly improve identification and classification, and drive development of targeted individualized treatments.
AB - Signs of motor dysfunction are evidenced across a range of psychiatric disorders including schizophrenia. Historically, these features have been neglected but emerging theoretical and methodological advancements have shed new light on the utility of considering movement abnormalities. Indeed, the National Institute of Mental Health Research Domain Criteria initiative has recently met to develop a Motor Systems Domain. This reflects a growing appreciation for the enhanced reliability and validity that can come along with evaluating disturbances relevant to psychiatric illnesses from multiple levels of analysis, and conceptualizing these domains with respect to the complexity of their role in a broader integrated system (ie, weighing contributions and interactions between the cognitive, affective, and motor domains). This article discusses motor behaviors and seeks to explain how research into basal ganglia, cerebellar, and cortico-motor circuit function/dysfunction, grounded in brain circuitmotor behavior relationships, can elucidate our understanding of pathophysiology, provide vital links to other key systems of interest, significantly improve identification and classification, and drive development of targeted individualized treatments.
KW - RDoC
KW - basal ganglia
KW - cerebellum
KW - cortico-motor circuits
KW - motor
KW - movement abnormalities
KW - psychosis
KW - schizophrenia
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U2 - 10.1093/schbul/sbx087
DO - 10.1093/schbul/sbx087
M3 - Review article
C2 - 28911048
AN - SCOPUS:85032032934
SN - 0586-7614
VL - 43
SP - 949
EP - 955
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 5
ER -