Well-ordered mesoporous silica nanoparticles as cell markers

Yu Shen Lin, Chih Pin Tsai, Hsing Yi Huang, Chieh Ti Kuo, Yann Hung, Dong Ming Huang, Yao Chang Chen, Chung Yuan Mou

Research output: Contribution to journalArticlepeer-review

419 Citations (Scopus)


Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.

Original languageEnglish
Pages (from-to)4570-4573
Number of pages4
JournalChemistry of Materials
Issue number18
Publication statusPublished - Sept 6 2005
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry


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