Well-ordered mesoporous silica nanoparticles as cell markers

Yu Shen Lin; Chih Pin Tsai; Hsing Yi Huang; Chieh Ti Kuo; Yann Hung; Dong Ming Huang; Yao Chang Chen; Chung Yuan Mou

doi:10.1021/cm051014c

Well-ordered mesoporous silica nanoparticles as cell markers

Yu Shen Lin, Chih Pin Tsai, Hsing Yi Huang, Chieh Ti Kuo, Yann Hung, Dong Ming Huang, Yao Chang Chen, Chung Yuan Mou

Research output: Contribution to journal › Article › peer-review

431 Citations (Scopus)

Abstract

Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.

Original language	English
Pages (from-to)	4570-4573
Number of pages	4
Journal	Chemistry of Materials
Volume	17
Issue number	18
DOIs	https://doi.org/10.1021/cm051014c
Publication status	Published - Sept 6 2005
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Materials Chemistry

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10.1021/cm051014c

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title = "Well-ordered mesoporous silica nanoparticles as cell markers",

abstract = "Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.",

author = "Lin, {Yu Shen} and Tsai, {Chih Pin} and Huang, {Hsing Yi} and Kuo, {Chieh Ti} and Yann Hung and Huang, {Dong Ming} and Chen, {Yao Chang} and Mou, {Chung Yuan}",

year = "2005",

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T1 - Well-ordered mesoporous silica nanoparticles as cell markers

AU - Lin, Yu Shen

AU - Tsai, Chih Pin

AU - Huang, Hsing Yi

AU - Kuo, Chieh Ti

AU - Hung, Yann

AU - Huang, Dong Ming

AU - Chen, Yao Chang

AU - Mou, Chung Yuan

PY - 2005/9/6

Y1 - 2005/9/6

N2 - Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.

AB - Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells.

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JO - Chemistry of Materials

JF - Chemistry of Materials

IS - 18

ER -

Well-ordered mesoporous silica nanoparticles as cell markers

Abstract

ASJC Scopus subject areas

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