Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy

Shih Hsun Cheng; Cheng Chih Hsieh; Nai Tzu Chen; Chia Hui Chu; Ching Mao Huang; Pi Tai Chou; Fan Gang Tseng; Chung Shi Yang; Chung Yuan Mou; Leu Wei Lo

doi:10.1016/j.nantod.2011.10.003

Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy

Shih Hsun Cheng, Cheng Chih Hsieh, Nai Tzu Chen, Chia Hui Chu, Ching Mao Huang, Pi Tai Chou, Fan Gang Tseng, Chung Shi Yang, Chung Yuan Mou, Leu Wei Lo

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Two-photon activated-photodynamic therapy (TPA-PDT) allows for spatially selective treatment of cancers, and enhances the tissue penetration depth of incident light. The three dimensional (3D) interface energy transfers in hexagonal mesoporous silica nanoparticles (MSNs) can significantly enhance the photodynamic effect. By providing a well-defined mesoporous nanostructure, we established an efficient and controllable energy transfer mechanism via the facile modification of a two-photon antenna molecule and photosensitizer on different topological domains in the MSN. The cytotoxicity induced by the singlet oxygen, generated following relay of energy transfer, was demonstrated in both in vitro and in vivo breast cancer models. Therefore, our results contribute new insight to the highly efficient energy transfer within a single nanoparticle for two-photon activated PDT, worthwhile for studying its potential for development in clinical translation.

Original language	English
Pages (from-to)	552-563
Number of pages	12
Journal	Nano Today
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.nantod.2011.10.003
Publication status	Published - Dec 2011
Externally published	Yes

Keywords

Energy transfer
Mesoporous silica nanoparticles
Two-photon activated-photodynamic therapy

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
General Materials Science
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nantod.2011.10.003

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title = "Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy",

abstract = "Two-photon activated-photodynamic therapy (TPA-PDT) allows for spatially selective treatment of cancers, and enhances the tissue penetration depth of incident light. The three dimensional (3D) interface energy transfers in hexagonal mesoporous silica nanoparticles (MSNs) can significantly enhance the photodynamic effect. By providing a well-defined mesoporous nanostructure, we established an efficient and controllable energy transfer mechanism via the facile modification of a two-photon antenna molecule and photosensitizer on different topological domains in the MSN. The cytotoxicity induced by the singlet oxygen, generated following relay of energy transfer, was demonstrated in both in vitro and in vivo breast cancer models. Therefore, our results contribute new insight to the highly efficient energy transfer within a single nanoparticle for two-photon activated PDT, worthwhile for studying its potential for development in clinical translation.",

keywords = "Energy transfer, Mesoporous silica nanoparticles, Two-photon activated-photodynamic therapy",

author = "Cheng, {Shih Hsun} and Hsieh, {Cheng Chih} and Chen, {Nai Tzu} and Chu, {Chia Hui} and Huang, {Ching Mao} and Chou, {Pi Tai} and Tseng, {Fan Gang} and Yang, {Chung Shi} and Mou, {Chung Yuan} and Lo, {Leu Wei}",

note = "Funding Information: The study was supported by the Grants MED-099-PP-04 and NM-099-PP-01 from National Health Research Institutes of Taiwan , and NSC 98–2221-E-400–001 and NSC 99–2113-M-400–001-MY3 from the National Science Council of Taiwan . We thank Ms. Yu-Ching Chen for her assistance on TEM measurements ",

year = "2011",

month = dec,

doi = "10.1016/j.nantod.2011.10.003",

language = "English",

volume = "6",

pages = "552--563",

journal = "Nano Today",

issn = "1748-0132",

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TY - JOUR

T1 - Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy

AU - Cheng, Shih Hsun

AU - Hsieh, Cheng Chih

AU - Chen, Nai Tzu

AU - Chu, Chia Hui

AU - Huang, Ching Mao

AU - Chou, Pi Tai

AU - Tseng, Fan Gang

AU - Yang, Chung Shi

AU - Mou, Chung Yuan

AU - Lo, Leu Wei

N1 - Funding Information: The study was supported by the Grants MED-099-PP-04 and NM-099-PP-01 from National Health Research Institutes of Taiwan , and NSC 98–2221-E-400–001 and NSC 99–2113-M-400–001-MY3 from the National Science Council of Taiwan . We thank Ms. Yu-Ching Chen for her assistance on TEM measurements

PY - 2011/12

Y1 - 2011/12

N2 - Two-photon activated-photodynamic therapy (TPA-PDT) allows for spatially selective treatment of cancers, and enhances the tissue penetration depth of incident light. The three dimensional (3D) interface energy transfers in hexagonal mesoporous silica nanoparticles (MSNs) can significantly enhance the photodynamic effect. By providing a well-defined mesoporous nanostructure, we established an efficient and controllable energy transfer mechanism via the facile modification of a two-photon antenna molecule and photosensitizer on different topological domains in the MSN. The cytotoxicity induced by the singlet oxygen, generated following relay of energy transfer, was demonstrated in both in vitro and in vivo breast cancer models. Therefore, our results contribute new insight to the highly efficient energy transfer within a single nanoparticle for two-photon activated PDT, worthwhile for studying its potential for development in clinical translation.

AB - Two-photon activated-photodynamic therapy (TPA-PDT) allows for spatially selective treatment of cancers, and enhances the tissue penetration depth of incident light. The three dimensional (3D) interface energy transfers in hexagonal mesoporous silica nanoparticles (MSNs) can significantly enhance the photodynamic effect. By providing a well-defined mesoporous nanostructure, we established an efficient and controllable energy transfer mechanism via the facile modification of a two-photon antenna molecule and photosensitizer on different topological domains in the MSN. The cytotoxicity induced by the singlet oxygen, generated following relay of energy transfer, was demonstrated in both in vitro and in vivo breast cancer models. Therefore, our results contribute new insight to the highly efficient energy transfer within a single nanoparticle for two-photon activated PDT, worthwhile for studying its potential for development in clinical translation.

KW - Energy transfer

KW - Mesoporous silica nanoparticles

KW - Two-photon activated-photodynamic therapy

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Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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