Water ingestion reduces skin blood flow through sympathetic vasoconstriction

Chih Cherng Lu, Min Hui Li, Tso Chou Lin, Ta Liang Chen, Ruei Ming Chen, Che Se Tung, Ching Jiunn Tseng, Shung Tai Ho

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Objective: Water ingestion induces a pressor effect in patients with efferent baroreflex impairment and a mild pressor effect in elderly healthy subjects. However, water raised the total peripheral vascular resistance (TPR) without a prominent change in blood pressure in young healthy subjects. We try to investigate whether water elicits a cardiovascular response via regulating regional skin blood flow (SkBF) in young healthy subjects. Methods: In a randomized, controlled, crossover fashion, 15 healthy male subjects (19-27 years old) ingested either 500 (water session) or 50 ml of water (control). The heart rate, blood pressure, cardiac index, and TPR were measured using a Task Force Monitor. A laser Doppler velocimeter was used to determine the change in the SkBF at the left thenar eminence. Plasma catecholamines and their metabolites were also measured. Results: At 25 min after ingestion of 500 ml water, the cardiac index and SkBF significantly decreased compared to control. In contrast, the TPR significantly increased after ingestion of 500 ml water. Plasma dihydroxyphenylalanine significantly increased at 25 min after water. Interpretation: Water ingestion decreases the cardiac index to compensate for the increase in the TPR, leading to no net change in blood pressure in young healthy subjects. This study suggests that water decreases the SkBF, a mechanism that might account partly for the nature of osmopressor response to water in young healthy subjects.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalClinical Autonomic Research
Issue number2
Publication statusPublished - Apr 2012


  • Laser Doppler skin blood flow (SkBF)
  • Plasma catecholamines
  • Total peripheral vascular resistance (TPR)
  • Water ingestion

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology


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