Waning population immunity to measles in Taiwan

Chih Jung Chen; Ping Ing Lee; Yu Chia Hsieh; Po Yen Chen; Yu Huai Ho; Chee Jen Chang; Ding Ping Liu; Feng Yee Chang; Cheng Hsun Chiu; Yhu Chering Huang; Chin Yun Lee; Tzou Yien Lin

doi:10.1016/j.vaccine.2012.05.019

Waning population immunity to measles in Taiwan

Chih Jung Chen, Ping Ing Lee, Yu Chia Hsieh, Po Yen Chen, Yu Huai Ho, Chee Jen Chang, Ding Ping Liu, Feng Yee Chang, Cheng Hsun Chiu, Yhu Chering Huang, Chin Yun Lee, Tzou Yien Lin

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (≥35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older.

Original language	English
Pages (from-to)	6721-6727
Number of pages	7
Journal	Vaccine
Volume	30
Issue number	47
DOIs	https://doi.org/10.1016/j.vaccine.2012.05.019
Publication status	Published - Oct 19 2012
Externally published	Yes

Keywords

Measles
Seropositive rate
Taiwan
Waning immunity

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2012.05.019

Cite this

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title = "Waning population immunity to measles in Taiwan",

abstract = "To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (≥35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older.",

keywords = "Measles, Seropositive rate, Taiwan, Waning immunity",

author = "Chen, {Chih Jung} and Lee, {Ping Ing} and Hsieh, {Yu Chia} and Chen, {Po Yen} and Ho, {Yu Huai} and Chang, {Chee Jen} and Liu, {Ding Ping} and Chang, {Feng Yee} and Chiu, {Cheng Hsun} and Huang, {Yhu Chering} and Lee, {Chin Yun} and Lin, {Tzou Yien}",

note = "Funding Information: The study was supported by a grant from Centers for Disease Control in Taiwan ( DOH96-DC-1017 ). We thank Dr. Min-Shi Lee from National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes for his critical reading of the manuscript. ",

year = "2012",

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doi = "10.1016/j.vaccine.2012.05.019",

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T1 - Waning population immunity to measles in Taiwan

AU - Chen, Chih Jung

AU - Lee, Ping Ing

AU - Hsieh, Yu Chia

AU - Chen, Po Yen

AU - Ho, Yu Huai

AU - Chang, Chee Jen

AU - Liu, Ding Ping

AU - Chang, Feng Yee

AU - Chiu, Cheng Hsun

AU - Huang, Yhu Chering

AU - Lee, Chin Yun

AU - Lin, Tzou Yien

N1 - Funding Information: The study was supported by a grant from Centers for Disease Control in Taiwan ( DOH96-DC-1017 ). We thank Dr. Min-Shi Lee from National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes for his critical reading of the manuscript.

PY - 2012/10/19

Y1 - 2012/10/19

N2 - To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (≥35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older.

AB - To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (≥35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older.

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KW - Seropositive rate

KW - Taiwan

KW - Waning immunity

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Waning population immunity to measles in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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