Waning population immunity to measles in Taiwan

Chih Jung Chen, Ping Ing Lee, Yu Chia Hsieh, Po Yen Chen, Yu Huai Ho, Chee Jen Chang, Ding Ping Liu, Feng Yee Chang, Cheng Hsun Chiu, Yhu Chering Huang, Chin Yun Lee, Tzou Yien Lin

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (≥35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older.

Original languageEnglish
Pages (from-to)6721-6727
Number of pages7
Issue number47
Publication statusPublished - Oct 19 2012
Externally publishedYes


  • Measles
  • Seropositive rate
  • Taiwan
  • Waning immunity

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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