Volume-dependent overestimation of spontaneous intracerebral hematoma volume by the abc/2 formula

Chih Wei Wang, Chun Jung Juan, Yi Jui Liu, Hsian He Hsu, Hua Shan Liu, Cheng Yu Chen, Chun Jen Hsueh, Chung Ping Lo, Hung Wen Kao, Guo Shu Huang

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


Background: Although the ABC/2 formula has been widely used to estimate the volume of intracerebral hematoma (ICH), the formula tends to overestimate hematoma volume. The volume-related imprecision of the ABC/2 formula has not been documented quantitatively. Purpose: To investigate the volume-dependent overestimation of the ABC/2 formula by comparing it with computer-assisted volumetric analysis (CAVA). Material and Methods: Forty patients who had suffered spontaneous ICH and who had undergone non-enhanced brain computed tomography scans were enrolled in this study. The ICH volume was estimated based on the ABC/2 formula and also calculated by CAVA. Based on the ICH volume calculated by the CAVA method, the patients were divided into three groups: group 1 consisted of 17 patients with an ICH volume of less than 20 ml; group 2 comprised 13 patients with an ICH volume of 20 to 40 ml; and group 3 was composed of 10 patients with an ICH volume larger than 40 ml. Results: The mean estimated hematoma volume was 43.6 ml when using the ABC/2 formula, compared with 33.8 ml when using the CAVA method. The mean estimated difference was 1.3 ml, 4.4 ml, and 31.4 ml for groups 1, 2, and 3, respectively, corresponding to an estimation error of 9.9%, 16.7%, and 37.1% by the ABC/2 formula (P0.05). Conclusion: The ABC/2 formula significantly overestimates the volume of ICH. A positive association between the estimation error and the volume of ICH is demonstrated.

Original languageEnglish
Pages (from-to)306-311
Number of pages6
JournalActa Radiologica
Issue number3
Publication statusPublished - 2009
Externally publishedYes


  • Computed tomography
  • Computer-assisted volumetric analysis
  • Intracerebral hematoma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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