TY - JOUR
T1 - Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan
AU - Huang, Y. W.
AU - Liao, Y. T.
AU - Chen, W.
AU - Chen, C. L.
AU - Hu, J. T.
AU - Liu, C. J.
AU - Lai, M. Y.
AU - Chen, P. J.
AU - Chen, D. S.
AU - Yang, S. S.
AU - Kao, J. H.
N1 - Funding Information:
This study was supported by grants from the National Taiwan University Hospital; Cathay General Hospital (97-CGN01), Department of Health and the National Science Council, Executive Yuan, Taiwan; National Health Research Institutes, Taiwan; and Liver Disease Prevention and Treatment Research Foundation.
PY - 2010/1
Y1 - 2010/1
N2 - Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. We genotyped the BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) polymorphisms of VDR gene in 250 Taiwanese chronic hepatitis B virus (HBV) carriers who were categorized into six phenotypes. After adjustment for age and sex, the frequencies of the VDR B/b, B/a, B/T, B/a/T in patients with hepatitis flare(s) were lower than those without (7 vs 20%, P0.009; 1 vs 9%, P0.004; 3 vs 10%, P0.007; 1 vs 9%, P0.005, respectively); in contrast, T/t, A/T, A/t, b/A/t were higher in flare(s) (8 vs 3%, P0.003; 49 vs 34%, P0.027; 2 vs 1%, P0.004; 0.5 vs 0%, P0.001, respectively). In addition, B/b, B/B, T/t, b/A, B/a, B/A, B/T, B/t, A/t, b/A/T, B/a/T, B/A/T, B/A/t, b/A/t were higher in patients positive for HBeAg. The distribution of VDR genotypes was comparable between patients with and without hepatocellular carcinoma (HCC). VDR gene polymorphisms are associated with distinct clinical phenotypes in Taiwanese HBV carriers but not with HCC development.
AB - Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. We genotyped the BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) polymorphisms of VDR gene in 250 Taiwanese chronic hepatitis B virus (HBV) carriers who were categorized into six phenotypes. After adjustment for age and sex, the frequencies of the VDR B/b, B/a, B/T, B/a/T in patients with hepatitis flare(s) were lower than those without (7 vs 20%, P0.009; 1 vs 9%, P0.004; 3 vs 10%, P0.007; 1 vs 9%, P0.005, respectively); in contrast, T/t, A/T, A/t, b/A/t were higher in flare(s) (8 vs 3%, P0.003; 49 vs 34%, P0.027; 2 vs 1%, P0.004; 0.5 vs 0%, P0.001, respectively). In addition, B/b, B/B, T/t, b/A, B/a, B/A, B/T, B/t, A/t, b/A/T, B/a/T, B/A/T, B/A/t, b/A/t were higher in patients positive for HBeAg. The distribution of VDR genotypes was comparable between patients with and without hepatocellular carcinoma (HCC). VDR gene polymorphisms are associated with distinct clinical phenotypes in Taiwanese HBV carriers but not with HCC development.
KW - Chronic carrier
KW - Hepatitis B virus
KW - Hepatocellular carcinoma
KW - Polymorphism
KW - Vitamin D receptor
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U2 - 10.1038/gene.2009.65
DO - 10.1038/gene.2009.65
M3 - Article
C2 - 19693091
AN - SCOPUS:84984555556
SN - 1466-4879
VL - 11
SP - 87
EP - 93
JO - Genes and Immunity
JF - Genes and Immunity
IS - 1
ER -
