Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus

Ya Li Huang, Yen Lin Chen, Jiunn Diann Lin, Dee Pei, Pietro Pitrone, Jin Shuen Chen, Chung Ze Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: The prevalence of type 2 diabetes mellitus in adolescents has increased rapidly in recent decades. However, the role of adipokines on pathophysiology in young-onset type 2 diabetes mellitus (YDM) is not clear. In this article, we explored the relationships between the adipokines (visfatin and retinol binding protein 4 (RBP4)) and metabolic syndrome (MetS) components in both YDM and late-onset type 2 diabetes mellitus (ODM). Materials and Methods: There were 36 patients with YDM (23.6 ± 4.8 years) and 36 patients with ODM (54.3 ± 10.1 years) enrolled. Visfatin, RBP4, and MetS components were measured. The relationships between visfatin, RBP4 and MetS components were assessed in YDM and ODM. Results: The visfatin, but not the RPB4 level, was significantly higher in YDM than in ODM. After adjusting for age and body mass index, visfatin was not related to any MetS components except that there was a negative correlation with fasting plasma glucose (FPG). As for RPB4, triglyceride was found to be positively and FPG negatively related to RBP4 in YDM. However, in ODM, the only positive relationship that existed was between RBP4 and diastolic blood pressure. Conclusions: In conclusion, both visfatin and RBP4 had certain roles in diabetes and MetS although their relationships were different in YDM and ODM. Further studies are needed to explore their physiological and pathological effects in glucose metabolism.

Original languageEnglish
Article number1278
JournalMedicina (Lithuania)
Volume59
Issue number7
DOIs
Publication statusPublished - Jul 2023

Keywords

  • metabolic syndrome
  • old diabetes mellitus
  • retinol binding protein 4
  • visfatin
  • young diabetes mellitus

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus'. Together they form a unique fingerprint.

Cite this