Viral infection, psychopathology, and autonomic modulation among methadone users in Taiwan

Wei Lieh Huang, Li Ren Chang, Terry B.J. Kuo, Yu Hsuan Lin, Jia Ling Yang, Ying Zai Chen, Cheryl C.H. Yang

Research output: Contribution to journalArticlepeer-review


Aim: We aimed to explore the impact of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection on autonomic modulation in heroin users. Methods: Fifty-nine subjects were divided into three groups: no infection group, HCV infection group, and HIV infection group (IG). Heart rate variability of all participants was measured. Results: The high frequency power (a parasympathetic index) and the total power (a combined autonomic index) of the IG were significantly lower before and after taking methadone. Above finding could not be explained by psychopathology. Conclusions: The results indicated that early HIV infection may play a role in autonomic dysregulation in heroin users.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalHeroin Addiction and Related Clinical Problems
Issue number6
Publication statusPublished - Dec 1 2017
Externally publishedYes


  • Heart rate variability
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Methadone

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health


Dive into the research topics of 'Viral infection, psychopathology, and autonomic modulation among methadone users in Taiwan'. Together they form a unique fingerprint.

Cite this