TY - JOUR
T1 - Vasicine and structurally related quinazolines
AU - Nepali, Kunal
AU - Sharma, Sahil
AU - Ojha, Ritu
AU - Dhar, Kanaya Lal
N1 - Funding Information:
Bromhexine exhibited pH-dependent growth inhibition of strains of M. tuberculosis in a study conducted by Medical Research Council of Ireland.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.
AB - Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.
KW - Alkaloid
KW - Antitussive
KW - Bronchodilator
KW - Quinazoline
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=84872020460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872020460&partnerID=8YFLogxK
U2 - 10.1007/s00044-012-0002-5
DO - 10.1007/s00044-012-0002-5
M3 - Review article
AN - SCOPUS:84872020460
SN - 1054-2523
VL - 22
SP - 1
EP - 15
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
IS - 1
ER -