Vasicine and structurally related quinazolines

Kunal Nepali; Sahil Sharma; Ritu Ojha; Kanaya Lal Dhar

doi:10.1007/s00044-012-0002-5

Vasicine and structurally related quinazolines

Kunal Nepali, Sahil Sharma, Ritu Ojha, Kanaya Lal Dhar

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	Medicinal Chemistry Research
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/s00044-012-0002-5
Publication status	Published - Jan 1 2013
Externally published	Yes

Keywords

Alkaloid
Antitussive
Bronchodilator
Quinazoline
Synthesis

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1007/s00044-012-0002-5

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title = "Vasicine and structurally related quinazolines",

abstract = "Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.",

keywords = "Alkaloid, Antitussive, Bronchodilator, Quinazoline, Synthesis",

author = "Kunal Nepali and Sahil Sharma and Ritu Ojha and Dhar, {Kanaya Lal}",

note = "Funding Information: Bromhexine exhibited pH-dependent growth inhibition of strains of M. tuberculosis in a study conducted by Medical Research Council of Ireland.",

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doi = "10.1007/s00044-012-0002-5",

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T1 - Vasicine and structurally related quinazolines

AU - Nepali, Kunal

AU - Sharma, Sahil

AU - Ojha, Ritu

AU - Dhar, Kanaya Lal

N1 - Funding Information: Bromhexine exhibited pH-dependent growth inhibition of strains of M. tuberculosis in a study conducted by Medical Research Council of Ireland.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.

AB - Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.

KW - Alkaloid

KW - Antitussive

KW - Bronchodilator

KW - Quinazoline

KW - Synthesis

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DO - 10.1007/s00044-012-0002-5

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SP - 1

EP - 15

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

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Vasicine and structurally related quinazolines

Abstract

Keywords

ASJC Scopus subject areas

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