Vascular space occupancy-dependent functional MRI by tissue suppression

Changwei W. Wu, Kai Hsiang Chuang, Yau Yau Wai, Yung Liang Wan, Jyh Horng Chen, Ho Ling Liu

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Purpose: To measure the cerebral blood volume (CBV) dynamics during neural activation, a novel technique named vascular space occupancy (VASO)-based functional MRI (fMRI) was recently introduced for noninvasive CBV detection. However, its application is limited because of its low contrast-to-noise ratio (CNR) due to small signal change from the inverted blood. Materials and Methods: In this study a new approach-VASO with tissue suppression (VAST) - is proposed to enhance CNR. This technique is compared with VASO and blood oxygenation level-dependent (BOLD) fMRI in block-design and event-related visual experiments. Results: Based on acquired T1 maps, 75.3% of the activated pixels detected by VAST are located in the cortical gray matter. Temporal characteristics of functional responses obtained by VAST were consistent with that of VASO. Although the baseline signal was decreased by the tissue suppression, the CNR of VAST was about 43% higher than VASO. Conclusion: With the improved sensitivity, VAST fMRI provides a useful alternative for mapping the spatial/temporal features of regional CBV changes during brain activation. However, the technical imperfectness of VAST, such as the nonideal inversion efficiency and physiological contaminations, limits its application to precise CBV quantification.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number1
Publication statusPublished - Jul 1 2008
Externally publishedYes


  • BOLD
  • Cerebral blood volume
  • Functional MRI
  • Tissue suppression
  • VASO

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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