Using three-dimensional multigrid-based snake and multiresolution image registration for reconstruction of cranial defect

Yuan-Lin Liao, Chia-Feng Lu, Chieh-Tsai Wu, Jiann-Der Lee, Shih-Tseng Lee, Yung-Nien Sun, Yu-Te Wu

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


In cranioplasty, neurosurgeons use bone grafts to repair skull defects. To ensure the protection of intracranial tissues and recover the original head shape for aesthetic purposes, a custom-made pre-fabricated prosthesis must match the cranial incision as closely as possible. In our previous study (Liao et al. in Med Biol Eng Comput 49:203-211, 2011), we proposed an algorithm consisting of the 2D snake and image registration using the patient's own diagnostic low-resolution and defective high-resolution computed tomography (CT) images to repair the impaired skull. In this study, we developed a 3D multigrid snake and employed multiresolution image registration to improve the computational efficiency. After extracting the defect portion images, we designed an image-trimming process to remove the bumped inner margin that can facilitate the placement of skull implants without manual trimming during surgery. To evaluate the performance of the proposed algorithm, a set of skull phantoms were manufactured to simulate six different conditions of cranial defects, namely, unilateral, bilateral, and cross-midline defects with 20 or 40 % skull defects. The overall image processing time in reconstructing the defect portion images can be reduced from 3 h to 20 min, as compared with our previous method. Furthermore, the reconstruction accuracies using the 3D multigrid snake were superior to those using the 2D snake. © 2012 International Federation for Medical and Biological Engineering.
Original languageEnglish
Pages (from-to)89-101
Number of pages13
JournalMedical and Biological Engineering and Computing
Issue number1-2
Publication statusPublished - 2013
Externally publishedYes


  • Active contour model
  • Computed tomography
  • Cranial defect
  • Image registration
  • Skull reconstruction
  • Bone graft
  • Computed Tomography
  • Cranial defects
  • Cranioplasty
  • Head shapes
  • High-resolution computed tomography
  • Low resolution
  • Multi-grid
  • Multiresolution images
  • Reconstruction accuracy
  • Algorithms
  • Computerized tomography
  • Defects
  • Image matching
  • Musculoskeletal system
  • Three dimensional computer graphics
  • Tissue
  • Trimming
  • Three dimensional
  • algorithm
  • article
  • computer simulation
  • human
  • image quality
  • male
  • methodology
  • pathology
  • prostheses and orthoses
  • skull
  • three dimensional imaging
  • young adult
  • procedures
  • Computer Simulation
  • Humans
  • Imaging, Three-Dimensional
  • Male
  • Phantoms, Imaging
  • Prostheses and Implants
  • Skull
  • Young Adult


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