Usefulness of glycated hemoglobin A1c-based adjusted glycemic variables in diabetic patients presenting with acute ischemic stroke

Chih Jen Yang, Wen I. Liao, Jen Chun Wang, Chia Lin Tsai, Jiunn Tay Lee, Giia Sheun Peng, Chien Hsing Lee, Chin Wang Hsu, Shih Hung Tsai

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Acute hyperglycemia is a common condition among patients with diabetes who are admitted to the emergency department (ED) for acute ischemic stroke (AIS). Previous findings regarding the association between hyperglycemia at admission and adverse outcomes among patients with diabetes and AIS have been inconsistent. When investigating this association, it is necessary to consider premorbid blood glucose control. The objective of the current study was to assess whether HbA1c-based adjusted glycemic variables were associated with unfavorable outcomes among patients admitted to the hospital for AIS. We retrospectively analyzed data from 309 patients who were hospitalized for AIS at a single medical center in Taiwan between January 1, 2013, and October 31, 2015. We found that 1) HbA1c-based adjusted glycemic variables, including the glycemic gap and stress hyperglycemia ratio, were associated with both AIS severity and neurological status at discharge; additionally, 2) HbA1c-based adjusted glycemic variables showed superior discriminative power compared with acute hyperglycemia regarding the development of severe AIS. We conclude that both the glycemic gap and stress hyperglycemia ratio might be useful in assessing the disease severity and prognosis of patients presenting with AIS. Further prospective long-term follow-up studies should be performed to validate these findings.

Original languageEnglish
Pages (from-to)1240-1246
Number of pages7
JournalAmerican Journal of Emergency Medicine
Issue number9
Publication statusPublished - Sept 1 2017


  • Acute ischemic stroke
  • Diabetes mellitus
  • Glycated hemoglobin
  • Hyperglycemia, glycemic gap, stress hyperglycemia ratio, stress-induced hyperglycemia
  • Outcome assessment

ASJC Scopus subject areas

  • Emergency Medicine


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