Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma

Ruoh-Fang Yen; Lai-Lei Ting; Mei-Fang Cheng; Yen-Wen Wu; Kai-Yuan Tzen; Ruey-Long Hong

doi:10.1002/hed.21026

Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma

Ruoh-Fang Yen
, Lai-Lei Ting
, Mei-Fang Cheng
, Yen-Wen Wu
, Kai-Yuan Tzen
, Ruey-Long Hong

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).

METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.

RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.

CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.

Original language	English
Pages (from-to)	717-24
Number of pages	8
Journal	Head and Neck
Volume	31
Issue number	6
DOIs	https://doi.org/10.1002/hed.21026
Publication status	Published - Jun 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Aged
Cohort Studies
Female
Fluorodeoxyglucose F18
Humans
Image Interpretation, Computer-Assisted
Logistic Models
Male
Middle Aged
Nasopharyngeal Neoplasms/diagnostic imaging
Neoplasm Recurrence, Local/diagnostic imaging
Positron-Emission Tomography/methods
Predictive Value of Tests
Probability
Prospective Studies
ROC Curve
Radiopharmaceuticals
Sensitivity and Specificity
Skull Base/diagnostic imaging
Tomography, Emission-Computed, Single-Photon/methods

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10.1002/hed.21026

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@article{1b7de94682ee4f4aa6a9db608bdee68d,

title = "Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma",

abstract = "BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7\% and 100\%, and those for (18)F-FDG PET/CT were 86.7\% and 75.0\%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.",

keywords = "Adult, Aged, Cohort Studies, Female, Fluorodeoxyglucose F18, Humans, Image Interpretation, Computer-Assisted, Logistic Models, Male, Middle Aged, Nasopharyngeal Neoplasms/diagnostic imaging, Neoplasm Recurrence, Local/diagnostic imaging, Positron-Emission Tomography/methods, Predictive Value of Tests, Probability, Prospective Studies, ROC Curve, Radiopharmaceuticals, Sensitivity and Specificity, Skull Base/diagnostic imaging, Tomography, Emission-Computed, Single-Photon/methods",

author = "Ruoh-Fang Yen and Lai-Lei Ting and Mei-Fang Cheng and Yen-Wen Wu and Kai-Yuan Tzen and Ruey-Long Hong",

year = "2009",

month = jun,

doi = "10.1002/hed.21026",

language = "English",

volume = "31",

pages = "717--24",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma

AU - Yen, Ruoh-Fang

AU - Ting, Lai-Lei

AU - Cheng, Mei-Fang

AU - Wu, Yen-Wen

AU - Tzen, Kai-Yuan

AU - Hong, Ruey-Long

PY - 2009/6

Y1 - 2009/6

N2 - BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.

AB - BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.

KW - Adult

KW - Aged

KW - Cohort Studies

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Nasopharyngeal Neoplasms/diagnostic imaging

KW - Neoplasm Recurrence, Local/diagnostic imaging

KW - Positron-Emission Tomography/methods

KW - Predictive Value of Tests

KW - Probability

KW - Prospective Studies

KW - ROC Curve

KW - Radiopharmaceuticals

KW - Sensitivity and Specificity

KW - Skull Base/diagnostic imaging

KW - Tomography, Emission-Computed, Single-Photon/methods

U2 - 10.1002/hed.21026

DO - 10.1002/hed.21026

M3 - Article

C2 - 19189341

SN - 1043-3074

VL - 31

SP - 717

EP - 724

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma

Abstract

UN SDGs

Keywords

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