Urinary microRNA in Diabetic Kidney Disease: A Literature Review

Chin Chan Lee, Chia Chun Chen, Cheng Kai Hsu, Yih Ting Chen, Chun Yu Chen, Kai Jie Yang, Ming Jui Hung, I. Wen Wu

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Diabetic kidney disease is the most common primary disease of end-stage kidney disease globally; however, a sensitive and accurate biomarker to predict this disease remains awaited. microRNAs are endogenous single-stranded noncoding RNAs that have intervened in different post-transcriptional regulations of various cellular biological functions. Previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of Transforming Growth Factor-β1-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. In this review, we describe the available experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and discuss the future application of microRNA in routine practice.

Original languageEnglish
Article number354
JournalMedicina (Lithuania)
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 2023
Externally publishedYes

Keywords

  • diabetes mellitus
  • diabetic kidney disease
  • exosomes
  • microRNA
  • urinary

ASJC Scopus subject areas

  • General Medicine

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