Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study

Tsan Yang, Chi Hong Chu, Chyi Huey Bai, San Lin You, Yu Ching Chou, Wan Yun Chou, Kuo Liong Chien, Lee Ching Hwang, Ta Chen Su, Chin Hsiao Tseng, Chien An Sun

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123 Citations (Scopus)


Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited. Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7. mg/dL for men and ≥6.6. mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations. Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend <0.001). Among women, this association was more robust than in men. After adjustment for age, variations of blood pressure, triglycerides, HDL-C, glucose, and waist circumference, females in the middle and upper tertiles of SUA had significantly higher risk of developing MetS when compared with subjects in the lowest tertile [adjusted-HR (95% CI) was 1.67 (1.12-2.49) and 3.18 (2.20-4.60), respectively; p for trend <0.001]. Overall, hyperuricemia was a significantly independent risk determinant for MetS in women, but it was a non-significant factor for MetS mediating waist circumference and serum triglycerides in men. Conclusion: SUA concentration is more closely associated with MetS in females than in males. Future investigations are needed to explore the underlying mechanisms involved in the sex-related association between SUA concentration and MetS risk.

Original languageEnglish
Pages (from-to)525-531
Number of pages7
Issue number2
Publication statusPublished - Feb 2012


  • Cohort study
  • Hyperuricemia
  • Metabolic syndrome
  • Uric acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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