Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study

Tsan Yang, Chi Hong Chu, Chyi Huey Bai, San Lin You, Yu Ching Chou, Lee Ching Hwang, Kuo Liong Chien, Ta Chen Su, Chin Hsiao Tseng, Chien An Sun

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.

Original languageEnglish
Pages (from-to)1747-1755
Number of pages9
JournalMetabolism: Clinical and Experimental
Issue number12
Publication statusPublished - Dec 2012


  • Abdominal obesity
  • Longitudinal study
  • Serum uric acid

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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