Uremic toxins-novel arrhythmogenic factor in chronic kidney disease-related atrial fibrillation

Shih Yu Huang; Yi Ann Chen; Shih Ann Chen; Yi Jen Chen; Yung Kuo Lin

doi:10.6515/ACS20151116A

Uremic toxins-novel arrhythmogenic factor in chronic kidney disease-related atrial fibrillation

Shih Yu Huang, Yi Ann Chen, Shih Ann Chen, Yi Jen Chen, Yung Kuo Lin

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Chronic kidney disease (CKD) is associated with a high prevalence of AF, and uremic toxins are an important risk factor for cardiovascular diseases associated with CKD. Uremic toxins can produce pro-fibrotic, pro-hypertrophic, and pro-inflammatory effects on cardiac tissues and enhance oxidative stress or neurohormonal phenomena of cardiovascular injury, which are recognized as arrhythmogenic factors of AF. This article reviews the clinical, molecular, and electrophysiological data of uremic toxins in CKD considered to induce AF through multiple mechanisms on structural and electrical remodeling of the cardiovascular system.

Original language	English
Pages (from-to)	259-264
Number of pages	6
Journal	Acta Cardiologica Sinica
Volume	32
Issue number	3
DOIs	https://doi.org/10.6515/ACS20151116A
Publication status	Published - May 2016

Keywords

Atrial fibrillation
Inflammation
Oxidative stress
Uremic toxins

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.6515/ACS20151116A

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title = "Uremic toxins-novel arrhythmogenic factor in chronic kidney disease-related atrial fibrillation",

abstract = "Atrial fibrillation (AF) is the most common cardiac arrhythmia. Chronic kidney disease (CKD) is associated with a high prevalence of AF, and uremic toxins are an important risk factor for cardiovascular diseases associated with CKD. Uremic toxins can produce pro-fibrotic, pro-hypertrophic, and pro-inflammatory effects on cardiac tissues and enhance oxidative stress or neurohormonal phenomena of cardiovascular injury, which are recognized as arrhythmogenic factors of AF. This article reviews the clinical, molecular, and electrophysiological data of uremic toxins in CKD considered to induce AF through multiple mechanisms on structural and electrical remodeling of the cardiovascular system.",

keywords = "Atrial fibrillation, Inflammation, Oxidative stress, Uremic toxins",

author = "Huang, {Shih Yu} and Chen, {Yi Ann} and Chen, {Shih Ann} and Chen, {Yi Jen} and Lin, {Yung Kuo}",

note = "Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan, (MOST103-2314-B-038-041-MY2, MOST103-2314-B-281-005-MY2, MOST103- 2314-B-281-006, MOST103-2314-B-038-055), the Cathay General Hospital, Taiwan, (CGH-MR-10221, CGH-MR-10123), and the Taiwan Heart Rhythm Society (THRS-1501). Publisher Copyright: {\textcopyright} 2016, Republic of China Society of Cardiology. All Rights Reserved.",

year = "2016",

month = may,

doi = "10.6515/ACS20151116A",

language = "English",

volume = "32",

pages = "259--264",

journal = "Acta Cardiologica Sinica",

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publisher = "Republic of China Society of Cardiology",

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T1 - Uremic toxins-novel arrhythmogenic factor in chronic kidney disease-related atrial fibrillation

AU - Huang, Shih Yu

AU - Chen, Yi Ann

AU - Chen, Shih Ann

AU - Chen, Yi Jen

AU - Lin, Yung Kuo

N1 - Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan, (MOST103-2314-B-038-041-MY2, MOST103-2314-B-281-005-MY2, MOST103- 2314-B-281-006, MOST103-2314-B-038-055), the Cathay General Hospital, Taiwan, (CGH-MR-10221, CGH-MR-10123), and the Taiwan Heart Rhythm Society (THRS-1501). Publisher Copyright: © 2016, Republic of China Society of Cardiology. All Rights Reserved.

PY - 2016/5

Y1 - 2016/5

N2 - Atrial fibrillation (AF) is the most common cardiac arrhythmia. Chronic kidney disease (CKD) is associated with a high prevalence of AF, and uremic toxins are an important risk factor for cardiovascular diseases associated with CKD. Uremic toxins can produce pro-fibrotic, pro-hypertrophic, and pro-inflammatory effects on cardiac tissues and enhance oxidative stress or neurohormonal phenomena of cardiovascular injury, which are recognized as arrhythmogenic factors of AF. This article reviews the clinical, molecular, and electrophysiological data of uremic toxins in CKD considered to induce AF through multiple mechanisms on structural and electrical remodeling of the cardiovascular system.

AB - Atrial fibrillation (AF) is the most common cardiac arrhythmia. Chronic kidney disease (CKD) is associated with a high prevalence of AF, and uremic toxins are an important risk factor for cardiovascular diseases associated with CKD. Uremic toxins can produce pro-fibrotic, pro-hypertrophic, and pro-inflammatory effects on cardiac tissues and enhance oxidative stress or neurohormonal phenomena of cardiovascular injury, which are recognized as arrhythmogenic factors of AF. This article reviews the clinical, molecular, and electrophysiological data of uremic toxins in CKD considered to induce AF through multiple mechanisms on structural and electrical remodeling of the cardiovascular system.

KW - Atrial fibrillation

KW - Inflammation

KW - Oxidative stress

KW - Uremic toxins

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DO - 10.6515/ACS20151116A

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VL - 32

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EP - 264

JO - Acta Cardiologica Sinica

JF - Acta Cardiologica Sinica

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ER -

Uremic toxins-novel arrhythmogenic factor in chronic kidney disease-related atrial fibrillation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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