Uremic toxins-novel arrhythmogenic factor in chronic kidney disease-related atrial fibrillation

Shih Yu Huang, Yi Ann Chen, Shih Ann Chen, Yi Jen Chen, Yung Kuo Lin

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Atrial fibrillation (AF) is the most common cardiac arrhythmia. Chronic kidney disease (CKD) is associated with a high prevalence of AF, and uremic toxins are an important risk factor for cardiovascular diseases associated with CKD. Uremic toxins can produce pro-fibrotic, pro-hypertrophic, and pro-inflammatory effects on cardiac tissues and enhance oxidative stress or neurohormonal phenomena of cardiovascular injury, which are recognized as arrhythmogenic factors of AF. This article reviews the clinical, molecular, and electrophysiological data of uremic toxins in CKD considered to induce AF through multiple mechanisms on structural and electrical remodeling of the cardiovascular system.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalActa Cardiologica Sinica
Issue number3
Publication statusPublished - May 2016


  • Atrial fibrillation
  • Inflammation
  • Oxidative stress
  • Uremic toxins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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