Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients

Ta Chen Su; Chang Chuan Chan; Chiau Suong Liau; Lian Yu Lin; Hsian Li Kao; Kai Jen Chuang

doi:10.1097/01.hjr.0000219116.25415.c4

Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients

Ta Chen Su, Chang Chuan Chan, Chiau Suong Liau, Lian Yu Lin, Hsian Li Kao, Kai Jen Chuang

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

BACKGROUND: The cardiovascular effects on fibrinolytic activity by urban air pollution are still unknown. METHODS: Paired fasting blood samples during high and low air pollution days in Taipei were taken from a panel of 49 patients with coronary heart disease or multiple risk factors to study their fibrinolytic and inflammatory response to urban air pollution. Paired t-tests and mixed-effects models were used to determine the air pollution effects. RESULTS: Patients' plasma plasminogen activator inhibitor-1 levels were significantly increased when hourly concentrations of particulate matter with diameters less than 10 μm (PM10) were greater than 100 μg/m during the period 0800 to 1800 h. CONCLUSION: Urban air pollution has an adverse effect on plasma fibrinolytic function in a susceptible population.

Original language	English
Pages (from-to)	849-852
Number of pages	4
Journal	European Journal of Cardiovascular Prevention and Rehabilitation
Volume	13
Issue number	5
DOIs	https://doi.org/10.1097/01.hjr.0000219116.25415.c4
Publication status	Published - Oct 2006
Externally published	Yes

Keywords

Fibrinogen
Inflammation marker
Particulate matter
Plasminogen activator inhibitor-1
Urban air pollution

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Rehabilitation
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/01.hjr.0000219116.25415.c4

Cite this

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title = "Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients",

abstract = "BACKGROUND: The cardiovascular effects on fibrinolytic activity by urban air pollution are still unknown. METHODS: Paired fasting blood samples during high and low air pollution days in Taipei were taken from a panel of 49 patients with coronary heart disease or multiple risk factors to study their fibrinolytic and inflammatory response to urban air pollution. Paired t-tests and mixed-effects models were used to determine the air pollution effects. RESULTS: Patients' plasma plasminogen activator inhibitor-1 levels were significantly increased when hourly concentrations of particulate matter with diameters less than 10 μm (PM10) were greater than 100 μg/m during the period 0800 to 1800 h. CONCLUSION: Urban air pollution has an adverse effect on plasma fibrinolytic function in a susceptible population.",

keywords = "Fibrinogen, Inflammation marker, Particulate matter, Plasminogen activator inhibitor-1, Urban air pollution",

author = "Su, {Ta Chen} and Chan, {Chang Chuan} and Liau, {Chiau Suong} and Lin, {Lian Yu} and Kao, {Hsian Li} and Chuang, {Kai Jen}",

year = "2006",

month = oct,

doi = "10.1097/01.hjr.0000219116.25415.c4",

language = "English",

volume = "13",

pages = "849--852",

journal = "European Journal of Preventive Cardiology",

issn = "2047-4873",

publisher = "SAGE Publications Ltd",

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}

TY - JOUR

T1 - Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients

AU - Su, Ta Chen

AU - Chan, Chang Chuan

AU - Liau, Chiau Suong

AU - Lin, Lian Yu

AU - Kao, Hsian Li

AU - Chuang, Kai Jen

PY - 2006/10

Y1 - 2006/10

N2 - BACKGROUND: The cardiovascular effects on fibrinolytic activity by urban air pollution are still unknown. METHODS: Paired fasting blood samples during high and low air pollution days in Taipei were taken from a panel of 49 patients with coronary heart disease or multiple risk factors to study their fibrinolytic and inflammatory response to urban air pollution. Paired t-tests and mixed-effects models were used to determine the air pollution effects. RESULTS: Patients' plasma plasminogen activator inhibitor-1 levels were significantly increased when hourly concentrations of particulate matter with diameters less than 10 μm (PM10) were greater than 100 μg/m during the period 0800 to 1800 h. CONCLUSION: Urban air pollution has an adverse effect on plasma fibrinolytic function in a susceptible population.

AB - BACKGROUND: The cardiovascular effects on fibrinolytic activity by urban air pollution are still unknown. METHODS: Paired fasting blood samples during high and low air pollution days in Taipei were taken from a panel of 49 patients with coronary heart disease or multiple risk factors to study their fibrinolytic and inflammatory response to urban air pollution. Paired t-tests and mixed-effects models were used to determine the air pollution effects. RESULTS: Patients' plasma plasminogen activator inhibitor-1 levels were significantly increased when hourly concentrations of particulate matter with diameters less than 10 μm (PM10) were greater than 100 μg/m during the period 0800 to 1800 h. CONCLUSION: Urban air pollution has an adverse effect on plasma fibrinolytic function in a susceptible population.

KW - Fibrinogen

KW - Inflammation marker

KW - Particulate matter

KW - Plasminogen activator inhibitor-1

KW - Urban air pollution

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ER -

Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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