TY - JOUR
T1 - Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma
AU - Chiang, Wei Fan
AU - Yen, Ching Yu
AU - Lin, Chin Nan
AU - Liaw, Gwo An
AU - Chiu, Chang Ta
AU - Hsia, Yu
AU - Liu, Shyun Yeu
PY - 2006/8
Y1 - 2006/8
N2 - The Pim-1 proto-oncogene, encoding a serine-threonine kinase, has been found to play an important role in regulating apoptosis, differentiation, proliferation and tumourigenesis. The present study was conducted to assess the importance of Pim-1 in oral tumourigenesis in vivo. Reverse transcriptase-polymerase chain reaction and immunohistochemistry were used to study the expression of Pim-1 in oral squamous cell carcinoma (OSCC) and non-cancerous match tissue (NCMT) sampled from the periphery of the tumours. Pim-1 mRNA expression in OSCC was significantly higher than that in NCMT in 36 tissue pairs (1.33 ± 0.41 versus 0.97 ± 0.29, P = 0.03). The percentage of OSCCs exhibiting strong cytoplasmic Pim-1 immunoreactivity was significantly higher than that of NCMT (60% versus 19%, P = 0.007). Pim-1 immunoreactivity is higher in the more differentiated components of a tumour. In around 10% of OSCC cases, Pim-1 immunoreactivity was found in the nucleus as well. These results show novel findings of the up-regulation of Pim-1 expression from NCMT to OSCC. The pathogenetic role of Pim-1 expression in oral tumourigenesis deserves further investigation.
AB - The Pim-1 proto-oncogene, encoding a serine-threonine kinase, has been found to play an important role in regulating apoptosis, differentiation, proliferation and tumourigenesis. The present study was conducted to assess the importance of Pim-1 in oral tumourigenesis in vivo. Reverse transcriptase-polymerase chain reaction and immunohistochemistry were used to study the expression of Pim-1 in oral squamous cell carcinoma (OSCC) and non-cancerous match tissue (NCMT) sampled from the periphery of the tumours. Pim-1 mRNA expression in OSCC was significantly higher than that in NCMT in 36 tissue pairs (1.33 ± 0.41 versus 0.97 ± 0.29, P = 0.03). The percentage of OSCCs exhibiting strong cytoplasmic Pim-1 immunoreactivity was significantly higher than that of NCMT (60% versus 19%, P = 0.007). Pim-1 immunoreactivity is higher in the more differentiated components of a tumour. In around 10% of OSCC cases, Pim-1 immunoreactivity was found in the nucleus as well. These results show novel findings of the up-regulation of Pim-1 expression from NCMT to OSCC. The pathogenetic role of Pim-1 expression in oral tumourigenesis deserves further investigation.
KW - oral cancer
KW - Pim-1
UR - http://www.scopus.com/inward/record.url?scp=33745220298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745220298&partnerID=8YFLogxK
U2 - 10.1016/j.ijom.2006.01.027
DO - 10.1016/j.ijom.2006.01.027
M3 - Article
C2 - 16546353
AN - SCOPUS:33745220298
SN - 0901-5027
VL - 35
SP - 740
EP - 745
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 8
ER -
