Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma

Wei Fan Chiang, Ching Yu Yen, Chin Nan Lin, Gwo An Liaw, Chang Ta Chiu, Yu Hsia, Shyun Yeu Liu

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39 Citations (Scopus)


The Pim-1 proto-oncogene, encoding a serine-threonine kinase, has been found to play an important role in regulating apoptosis, differentiation, proliferation and tumourigenesis. The present study was conducted to assess the importance of Pim-1 in oral tumourigenesis in vivo. Reverse transcriptase-polymerase chain reaction and immunohistochemistry were used to study the expression of Pim-1 in oral squamous cell carcinoma (OSCC) and non-cancerous match tissue (NCMT) sampled from the periphery of the tumours. Pim-1 mRNA expression in OSCC was significantly higher than that in NCMT in 36 tissue pairs (1.33 ± 0.41 versus 0.97 ± 0.29, P = 0.03). The percentage of OSCCs exhibiting strong cytoplasmic Pim-1 immunoreactivity was significantly higher than that of NCMT (60% versus 19%, P = 0.007). Pim-1 immunoreactivity is higher in the more differentiated components of a tumour. In around 10% of OSCC cases, Pim-1 immunoreactivity was found in the nucleus as well. These results show novel findings of the up-regulation of Pim-1 expression from NCMT to OSCC. The pathogenetic role of Pim-1 expression in oral tumourigenesis deserves further investigation.

Original languageEnglish
Pages (from-to)740-745
Number of pages6
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number8
Publication statusPublished - Aug 2006


  • oral cancer
  • Pim-1

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology
  • Surgery


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