Unusual clonal evolution in a case of chronic myelogenous leukemia

J. Whang Peng, S. Broder, E. Lee, R. C. Young

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5 Citations (Scopus)


Several unusual cytogenetic changes have occurred during the evolution of chronic myelogenous leukemia in a 32 year old white male with this disease for 8 years. The first appearance of a hypodiploid cell line containing a dicentric marker occurred 2 years after diagnosis and this line was eliminated by several courses of therapy with hydroxyurea. A second clone, which had a partial deletion of the long arm of one of the number 8 chromosomes (8q-) was noted a year later, but this line is refractory to intensive combination chemotherapy.

Original languageEnglish
Pages (from-to)345-354
Number of pages10
JournalActa Haematologica
Issue number6
Publication statusPublished - Dec 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • Hematology


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