TY - JOUR
T1 - Unprecedented green-emissive boranyl-hydrazone supramolecular assemblies and their in vitro diagnostic applications
AU - Pandith, Anup
AU - Kim, Hye Yeon
AU - Shin, Taeho
AU - Seo, Young Jun
N1 - Funding Information:
Our research has been supported by the Basic Science Research Program through the National Research Foundation of Korea ( 2017R1A2B4002398 ) funded by the Republic of Korea. A.P. thanks Professor Hong-Seok Kim, Kyungpook National University, for providing the computational (SPARTAN 04) facilities.
Funding Information:
Our research has been supported by the Basic Science Research Program through the National Research Foundation of Korea (2017R1A2B4002398) funded by the Republic of Korea. A.P. thanks Professor Hong-Seok Kim, Kyungpook National University, for providing the computational (SPARTAN 04) facilities.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/8
Y1 - 2019/8
N2 - This paper describes a novel symmetric N,N′-diethylsalicylaldehyde boranyl hydrazone (1) and its in situ-generated assemblies displaying opto-analytical capabilities for the diagnosis of nucleic acids under physiological conditions. The sensing capabilities of these unprecedented supramolecular assemblies were characterized using UV–Vis spectroscopy, fluorescence spectroscopy, 1D and 2D NMR spectroscopy, dynamic light scattering, and zeta potential measurements. Model compounds lacking boranyl units (2, 3) were prepared to correlate and evaluate the sensing mechanism. The rationally designed probe 1 displays unusual aggregation-induced emissive (AIE) properties, with an average particle size of 1096 nm exhibiting green emission upon excitation at 377 nm in pH-7.2 TRIZMA buffer. A selective switch on response toward organic PO4 3− accompanied through specific nano-aggregations patterns and sizes, thereby causing a significant red-shift through AIE. Exploiting such switch on in green channel behavior has allowed the monitoring of DNase I activities and polymerase chain reactions.
AB - This paper describes a novel symmetric N,N′-diethylsalicylaldehyde boranyl hydrazone (1) and its in situ-generated assemblies displaying opto-analytical capabilities for the diagnosis of nucleic acids under physiological conditions. The sensing capabilities of these unprecedented supramolecular assemblies were characterized using UV–Vis spectroscopy, fluorescence spectroscopy, 1D and 2D NMR spectroscopy, dynamic light scattering, and zeta potential measurements. Model compounds lacking boranyl units (2, 3) were prepared to correlate and evaluate the sensing mechanism. The rationally designed probe 1 displays unusual aggregation-induced emissive (AIE) properties, with an average particle size of 1096 nm exhibiting green emission upon excitation at 377 nm in pH-7.2 TRIZMA buffer. A selective switch on response toward organic PO4 3− accompanied through specific nano-aggregations patterns and sizes, thereby causing a significant red-shift through AIE. Exploiting such switch on in green channel behavior has allowed the monitoring of DNase I activities and polymerase chain reactions.
KW - Aggregation-induced emission
KW - Boranyl-hydrazone
KW - DNase I
KW - Nano-aggregates
KW - Polymerase chain reactions
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U2 - 10.1016/j.jphotobiol.2019.111553
DO - 10.1016/j.jphotobiol.2019.111553
M3 - Article
C2 - 31326845
AN - SCOPUS:85069490324
SN - 1011-1344
VL - 197
JO - Journal of Photochemistry and Photobiology B: Biology
JF - Journal of Photochemistry and Photobiology B: Biology
M1 - 111553
ER -