TY - GEN
T1 - Ultra-compliant peripheral nerve cuff electrode with hydrogel adhesion
AU - Ong, Xiao Chuan
AU - Huang, Wei Chen
AU - Kwon, Ik Soo
AU - Gopinath, Chaitanya
AU - Wu, Haosheng
AU - Fisher, Lee E.
AU - Gaunt, Robert A.
AU - Bettinger, Christopher J.
AU - Fedder, Gary K.
N1 - Funding Information:
We thank Dr. Matt Moneck and his staff in the Carnegie Mellon Nanofabrication Facility for their support in the fabrication equipment. This work was partially sponsored by the Defense Advanced Research Projects Agency (DARPA) BTO under the auspices of Dr. Douglas Weber through the Space and Naval Warfare Systems Center, Pacific Grant/Contract No. D14AP00040 and HR0011-15-2-0009). Any opinions, findings and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of SPAWAR or DARPA.
Publisher Copyright:
© 2018 IEEE.
PY - 2018/4/24
Y1 - 2018/4/24
N2 - This paper reports a method of fabricating peripheral nerve cuff electrodes attached to a sticky hydrogel. The nerve cuff electrode is much more compliant compared to typical cuff electrodes made of polyimide or PDMS and contains adhesion-promoting functional groups that allow for good electrical contact with the nerve without the need for continuous application of pressure on the nerve. A transfer process is used to fabricate the device using poly(acrylic acid) as the sacrificial material that has tunable solubility in aqueous media. This avoids the need for harsh release chemicals that may affect the properties of the hydrogel. The transfer process also allows for electrode contacts that are flush with the surface of the probe and allow intimate contact of with the nerve, as compared with typical recessed electrode contacts. Patterned SU-8 provides a gradual change in Young's modulus from the stiff pad region to the compliant electrode contact region. The measured impedance of the 75 μm radius Pt electrode contacts is ∼100 kΩ. In vivo recordings have been demonstrated using fabricated devices in the dorsal root ganglia of a cat.
AB - This paper reports a method of fabricating peripheral nerve cuff electrodes attached to a sticky hydrogel. The nerve cuff electrode is much more compliant compared to typical cuff electrodes made of polyimide or PDMS and contains adhesion-promoting functional groups that allow for good electrical contact with the nerve without the need for continuous application of pressure on the nerve. A transfer process is used to fabricate the device using poly(acrylic acid) as the sacrificial material that has tunable solubility in aqueous media. This avoids the need for harsh release chemicals that may affect the properties of the hydrogel. The transfer process also allows for electrode contacts that are flush with the surface of the probe and allow intimate contact of with the nerve, as compared with typical recessed electrode contacts. Patterned SU-8 provides a gradual change in Young's modulus from the stiff pad region to the compliant electrode contact region. The measured impedance of the 75 μm radius Pt electrode contacts is ∼100 kΩ. In vivo recordings have been demonstrated using fabricated devices in the dorsal root ganglia of a cat.
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U2 - 10.1109/MEMSYS.2018.8346566
DO - 10.1109/MEMSYS.2018.8346566
M3 - Conference contribution
AN - SCOPUS:85046995857
VL - 2018-January
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 376
EP - 379
BT - 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
Y2 - 21 January 2018 through 25 January 2018
ER -