Ubiquitin-Like Proteins

L. S. Lu, E. T.H. Yeh

Research output: Chapter in Book/Report/Conference proceedingChapter


Ubiquitin-like proteins (UBLs) are posttranslational modifiers with a structurally conserved β-grasp fold. These sequence-wise unrelated proteins share similar modification mechanism with ubiquitin and regulate every facet of eukaryote life. With rapidly advancing proteomic techniques, it is now possible to systemically decode UBL modification on protein functions. In this article, we first cover basic biochemical principles of UBL cycling. Then, a brief review of biological implications on several well-characterized UBLs (small ubiquitin-like modifiers (SUMOs), neural precursor cell expressed, developmentally down regulated 8 (NEDD8), interferon-induced 15-kDa protein (Isg15), Atg8, Atg12, and Fat10) is provided.

Original languageEnglish
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
Publication statusPublished - Feb 15 2013
Externally publishedYes


  • ATG12
  • ATG8
  • Cullins
  • FAT10
  • Interferon-induced 15-kDa protein (ISG15)
  • Neural precursor cell expressed, developmentally down regulated 8 (NEDD8)
  • Small ubiquitin-like modifier (SUMO)
  • Ubiquitin-like proteins (UBL)
  • UBL-binding domain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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