Tuberculosis-associated hemophagocytic syndrome in a hemodialysis patient with protracted fever

Chih Chiang Chien, Tzeon Jye Chiou, Ming Yang Lee, Liang Tsai Hsiao, Wei Kang Kwang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Hemophagocytic syndrome (HPS) is a clinicopathological reflection of uncontrolled activation of macrophages. To our knowledge, only a few cases of tuberculosis-associated HPS in hemodialysis have been reported in the English literature. We report a case of tuberculosis-associated HPS during hemodialysis. Bone marrow aspiration showed histiocytosis with hemophagocytosis; in addition, results of acid-fast staining and polymerase chain reaction showed the presence of acid-fast bacilli. Mycobacterium tuberculosis was subsequently cultured from sputum. The patient received late treatment with antituberculosis agents combined with intravenous immunoglobulin and had a poor response. On the basis of the results in this case, we recommend early bone marrow and tuberculous examination for patients undergoing maintenance hemodialysis who have fever of unknown origin.

Original languageEnglish
Pages (from-to)334-336
Number of pages3
JournalInternational Journal of Hematology
Issue number4
Publication statusPublished - May 2004
Externally publishedYes


  • Fever of unknown origin
  • Hemodialysis
  • Hemophagocytic syndrome

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Tuberculosis-associated hemophagocytic syndrome in a hemodialysis patient with protracted fever'. Together they form a unique fingerprint.

Cite this