Triterpenoidal saponins from Hydrocotyle sibthorpioides

Hui Chi Huang, Chia Ching Liaw, Li Jie Zhang, Hsi Uo Ho, Li Ming Yang Kuo, Ya Ching Shen, Yao Haur Kuo

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques (13C, 1H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.

Original languageEnglish
Pages (from-to)1597-1603
Number of pages7
Issue number7
Publication statusPublished - May 2008


  • Chemotaxonomy
  • Cytotoxicity
  • Hydrocotyle sibthorpioides
  • Oleanane-type triterpenoidal saponin
  • Umbelliferae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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