Triterpenoidal saponins from Hydrocotyle sibthorpioides

Hui Chi Huang; Chia Ching Liaw; Li Jie Zhang; Hsi Uo Ho; Li Ming Yang Kuo; Ya Ching Shen; Yao Haur Kuo

doi:10.1016/j.phytochem.2008.01.005

Triterpenoidal saponins from Hydrocotyle sibthorpioides

Hui Chi Huang, Chia Ching Liaw, Li Jie Zhang, Hsi Uo Ho, Li Ming Yang Kuo, Ya Ching Shen, Yao Haur Kuo

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques (¹³C, ¹H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.

Original language	English
Pages (from-to)	1597-1603
Number of pages	7
Journal	Phytochemistry
Volume	69
Issue number	7
DOIs	https://doi.org/10.1016/j.phytochem.2008.01.005
Publication status	Published - May 2008

Keywords

Chemotaxonomy
Cytotoxicity
Hydrocotyle sibthorpioides
Oleanane-type triterpenoidal saponin
Umbelliferae

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2008.01.005

Cite this

@article{9d39baf79e9749349ce9ae6787f5fcb6,

title = "Triterpenoidal saponins from Hydrocotyle sibthorpioides",

abstract = "Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques (13C, 1H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.",

keywords = "Chemotaxonomy, Cytotoxicity, Hydrocotyle sibthorpioides, Oleanane-type triterpenoidal saponin, Umbelliferae",

author = "Huang, {Hui Chi} and Liaw, {Chia Ching} and Zhang, {Li Jie} and Ho, {Hsi Uo} and Kuo, {Li Ming Yang} and Shen, {Ya Ching} and Kuo, {Yao Haur}",

note = "Funding Information: The authors like to thank the grants from National Science Council, Republic of China (NSC 93-2323-B-077-002) and National Research Institute of Chinese Medicine, Republic of China (NRICM-95-DHM-02) to Y.H. Kuo.",

year = "2008",

month = may,

doi = "10.1016/j.phytochem.2008.01.005",

language = "English",

volume = "69",

pages = "1597--1603",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

number = "7",

}

TY - JOUR

T1 - Triterpenoidal saponins from Hydrocotyle sibthorpioides

AU - Huang, Hui Chi

AU - Liaw, Chia Ching

AU - Zhang, Li Jie

AU - Ho, Hsi Uo

AU - Kuo, Li Ming Yang

AU - Shen, Ya Ching

AU - Kuo, Yao Haur

N1 - Funding Information: The authors like to thank the grants from National Science Council, Republic of China (NSC 93-2323-B-077-002) and National Research Institute of Chinese Medicine, Republic of China (NRICM-95-DHM-02) to Y.H. Kuo.

PY - 2008/5

Y1 - 2008/5

N2 - Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques (13C, 1H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.

AB - Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques (13C, 1H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.

KW - Chemotaxonomy

KW - Cytotoxicity

KW - Hydrocotyle sibthorpioides

KW - Oleanane-type triterpenoidal saponin

KW - Umbelliferae

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UR - http://www.scopus.com/inward/citedby.url?scp=42149148092&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2008.01.005

DO - 10.1016/j.phytochem.2008.01.005

M3 - Article

C2 - 18329675

AN - SCOPUS:42149148092

SN - 0031-9422

VL - 69

SP - 1597

EP - 1603

JO - Phytochemistry

JF - Phytochemistry

IS - 7

ER -

Triterpenoidal saponins from Hydrocotyle sibthorpioides

Abstract

Keywords

ASJC Scopus subject areas

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