Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity

Thanh Hoa Vo; Yu Chi Lin; Chia Ching Liaw; Wen Pin Pan; Jing Jy Cheng; Ching Kuo Lee; Yao Haur Kuo

doi:10.1016/j.phytochem.2021.112666

Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity

Thanh Hoa Vo, Yu Chi Lin, Chia Ching Liaw, Wen Pin Pan, Jing Jy Cheng, Ching Kuo Lee, Yao Haur Kuo

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

After anti-angiogenic activity screening, the potential n-butanol layer partitioned from the ethanol extract of Staurogyne concinnula was conducted. Further purification by Diaion HP20 column and preparative HPLC chromatography, four undescribed triterpenoid saponin derivatives, along with the known baptisiasaponin I, and four known phenylpropanoid glycosides were isolated and characterized from n-butanol layer. The structures of isolated compounds were elucidated by ESI-MS, 1D, and 2D MNR data. Biological evaluation revealed that baptisiasaponin I possessed significant anti-angiogenic effects (IC₅₀ 4.0 ± 0.2 μM). Further mechanism of action of baptisiasaponin I by inhibition of integrin/FAK/paxillin signaling pathway and its downstream effectors as MMP2 and MMP9 are also presented.

Original language	English
Article number	112666
Journal	Phytochemistry
Volume	184
DOIs	https://doi.org/10.1016/j.phytochem.2021.112666
Publication status	Published - Apr 2021

Keywords

Acanthaceae
Anti-angiogenic effect
MMP2
MMP9
Oleanane saponins
Staurogyne concinnula

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

Access to Document

10.1016/j.phytochem.2021.112666

Cite this

@article{cdf7d5034a364d7789094564a812b074,

title = "Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity",

abstract = "After anti-angiogenic activity screening, the potential n-butanol layer partitioned from the ethanol extract of Staurogyne concinnula was conducted. Further purification by Diaion HP20 column and preparative HPLC chromatography, four undescribed triterpenoid saponin derivatives, along with the known baptisiasaponin I, and four known phenylpropanoid glycosides were isolated and characterized from n-butanol layer. The structures of isolated compounds were elucidated by ESI-MS, 1D, and 2D MNR data. Biological evaluation revealed that baptisiasaponin I possessed significant anti-angiogenic effects (IC50 4.0 ± 0.2 μM). Further mechanism of action of baptisiasaponin I by inhibition of integrin/FAK/paxillin signaling pathway and its downstream effectors as MMP2 and MMP9 are also presented.",

keywords = "Acanthaceae, Anti-angiogenic effect, MMP2, MMP9, Oleanane saponins, Staurogyne concinnula",

author = "Vo, {Thanh Hoa} and Lin, {Yu Chi} and Liaw, {Chia Ching} and Pan, {Wen Pin} and Cheng, {Jing Jy} and Lee, {Ching Kuo} and Kuo, {Yao Haur}",

note = "Funding Information: This work was supported by grants from the Ministry of Health and Welfare (New Southbound Policy-NRICM-NSP-108-01, NRICM-NSP-109-01), and the Ministry of Science and Technology (MOST104-2320-B-077-006 -MY3, MOST107-2320-B-077-003-MY3), Taiwan. Publisher Copyright: {\textcopyright} 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = apr,

doi = "10.1016/j.phytochem.2021.112666",

language = "English",

volume = "184",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity

AU - Vo, Thanh Hoa

AU - Lin, Yu Chi

AU - Liaw, Chia Ching

AU - Pan, Wen Pin

AU - Cheng, Jing Jy

AU - Lee, Ching Kuo

AU - Kuo, Yao Haur

N1 - Funding Information: This work was supported by grants from the Ministry of Health and Welfare (New Southbound Policy-NRICM-NSP-108-01, NRICM-NSP-109-01), and the Ministry of Science and Technology (MOST104-2320-B-077-006 -MY3, MOST107-2320-B-077-003-MY3), Taiwan. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - After anti-angiogenic activity screening, the potential n-butanol layer partitioned from the ethanol extract of Staurogyne concinnula was conducted. Further purification by Diaion HP20 column and preparative HPLC chromatography, four undescribed triterpenoid saponin derivatives, along with the known baptisiasaponin I, and four known phenylpropanoid glycosides were isolated and characterized from n-butanol layer. The structures of isolated compounds were elucidated by ESI-MS, 1D, and 2D MNR data. Biological evaluation revealed that baptisiasaponin I possessed significant anti-angiogenic effects (IC50 4.0 ± 0.2 μM). Further mechanism of action of baptisiasaponin I by inhibition of integrin/FAK/paxillin signaling pathway and its downstream effectors as MMP2 and MMP9 are also presented.

AB - After anti-angiogenic activity screening, the potential n-butanol layer partitioned from the ethanol extract of Staurogyne concinnula was conducted. Further purification by Diaion HP20 column and preparative HPLC chromatography, four undescribed triterpenoid saponin derivatives, along with the known baptisiasaponin I, and four known phenylpropanoid glycosides were isolated and characterized from n-butanol layer. The structures of isolated compounds were elucidated by ESI-MS, 1D, and 2D MNR data. Biological evaluation revealed that baptisiasaponin I possessed significant anti-angiogenic effects (IC50 4.0 ± 0.2 μM). Further mechanism of action of baptisiasaponin I by inhibition of integrin/FAK/paxillin signaling pathway and its downstream effectors as MMP2 and MMP9 are also presented.

KW - Acanthaceae

KW - Anti-angiogenic effect

KW - MMP2

KW - MMP9

KW - Oleanane saponins

KW - Staurogyne concinnula

UR - http://www.scopus.com/inward/record.url?scp=85100033778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85100033778&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2021.112666

DO - 10.1016/j.phytochem.2021.112666

M3 - Article

AN - SCOPUS:85100033778

SN - 0031-9422

VL - 184

JO - Phytochemistry

JF - Phytochemistry

M1 - 112666

ER -

Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this