Trifunctional Fe3O4/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy

Yu Pu Wang; Yu Te Liao; Chia Hung Liu; Jiashing Yu; Hatem R. Alamri; Zeid A. Alothman; Md Shahriar A. Hossain; Yusuke Yamauchi; Kevin C.W. Wu

doi:10.1021/acsbiomaterials.7b00230

Trifunctional Fe₃O₄/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy

Yu Pu Wang, Yu Te Liao, Chia Hung Liu, Jiashing Yu, Hatem R. Alamri, Zeid A. Alothman, Md Shahriar A. Hossain, Yusuke Yamauchi, Kevin C.W. Wu

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe₃O₄) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe₃O₄/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe₃O₄/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe₃O₄/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.

Original language	English
Pages (from-to)	2366-2374
Number of pages	9
Journal	ACS Biomaterials Science and Engineering
Volume	3
Issue number	10
DOIs	https://doi.org/10.1021/acsbiomaterials.7b00230
Publication status	Published - Oct 9 2017

Keywords

bladder cancer
controlled release
core-shell-corona nanoparticles
magnetic guidance
targeting

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acsbiomaterials.7b00230

Cite this

Wang, Y. P., Liao, Y. T., Liu, C. H., Yu, J., Alamri, H. R., Alothman, Z. A., Hossain, M. S. A., Yamauchi, Y., & Wu, K. C. W. (2017). Trifunctional Fe₃O₄/CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy. ACS Biomaterials Science and Engineering, 3(10), 2366-2374. https://doi.org/10.1021/acsbiomaterials.7b00230

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abstract = "Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe3O4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe3O4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe3O4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe3O4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.",

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AU - Wang, Yu Pu

AU - Liao, Yu Te

AU - Liu, Chia Hung

AU - Yu, Jiashing

AU - Alamri, Hatem R.

AU - Alothman, Zeid A.

AU - Hossain, Md Shahriar A.

AU - Yamauchi, Yusuke

AU - Wu, Kevin C.W.

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N2 - Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe3O4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe3O4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe3O4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe3O4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.

AB - Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe3O4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe3O4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe3O4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe3O4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.

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