Tribological process induced conformational transformation of protein may change the friction of cartilage

Chih Hung Chang; Hsu Wei Fang; Huei Ting Huang; Hsuan Liang Liu; Wei Ming Lee; Man Ching Hsieh; Chiang San Chen

doi:10.1016/j.matlet.2006.11.077

Tribological process induced conformational transformation of protein may change the friction of cartilage

Chih Hung Chang, Hsu Wei Fang, Huei Ting Huang, Hsuan Liang Liu, Wei Ming Lee, Man Ching Hsieh, Chiang San Chen

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.

Original language	English
Pages (from-to)	3381-3384
Number of pages	4
Journal	Materials Letters
Volume	61
Issue number	16
DOIs	https://doi.org/10.1016/j.matlet.2006.11.077
Publication status	Published - Jun 1 2007
Externally published	Yes

Keywords

Albumin
Cartilage
Friction
Partial joint arthroplasty
Tribochemistry
UHMWPE

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.matlet.2006.11.077

Cite this

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title = "Tribological process induced conformational transformation of protein may change the friction of cartilage",

abstract = "In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.",

keywords = "Albumin, Cartilage, Friction, Partial joint arthroplasty, Tribochemistry, UHMWPE",

author = "Chang, {Chih Hung} and Fang, {Hsu Wei} and Huang, {Huei Ting} and Liu, {Hsuan Liang} and Lee, {Wei Ming} and Hsieh, {Man Ching} and Chen, {Chiang San}",

note = "Funding Information: The authors are pleased to acknowledge the financial support from the US Air Force (AOARD-05-4081) and the Far Eastern Memorial Hospital (FEMH-94-C-040), Taiwan.",

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doi = "10.1016/j.matlet.2006.11.077",

language = "English",

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AU - Chang, Chih Hung

AU - Fang, Hsu Wei

AU - Huang, Huei Ting

AU - Liu, Hsuan Liang

AU - Lee, Wei Ming

AU - Hsieh, Man Ching

AU - Chen, Chiang San

N1 - Funding Information: The authors are pleased to acknowledge the financial support from the US Air Force (AOARD-05-4081) and the Far Eastern Memorial Hospital (FEMH-94-C-040), Taiwan.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.

AB - In-vitro testing procedures have been successfully developed to investigate the effects of tribological process induced transformation of protein-based lubricant on the friction change of articular cartilages. Serum and albumin solutions were the biological lubricants used in this study. The results indicated that the lubricating ability for cartilages deteriorates after the biological lubricants were articulated between polyethylene and stainless steel materials. In addition, the secondary structure change of the albumin molecule has been characterized after the molecules were articulated by the artificial joint materials. We have provided evidence that the conformational change of protein lubricants leads to the friction increase of articular cartilage.

KW - Albumin

KW - Cartilage

KW - Friction

KW - Partial joint arthroplasty

KW - Tribochemistry

KW - UHMWPE

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Tribological process induced conformational transformation of protein may change the friction of cartilage

Abstract

Keywords

ASJC Scopus subject areas

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