Treatment of advanced gastric cancer with a modified regimen of etoposide/leucovorin/5-fluorouracil

Tzeon Jye Chiou, Sung Pao Kung, Ruey Kuen Hsieh, San Fan, Cheng Hwai Tzeng, Chih Hsin Wei, Po Min Chen

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3 Citations (Scopus)


The efficacy and toxicity of a combination of etoposide 100 mg/m2/day iv on day 2-4, leucovorin 300 mg/m2/day iv, and 5-FU 500 mg/m2 day iv on day 1-5 every 4 weeks were assessed in 21 patients with advanced gastric cancer with measurable or evaluable diseases. Eight patients had an objective response, including 3 in CR. The overall response rate was 38.1% (95% CI 33.4-42.8%). Five of 8 patients who exhibited locally advanced and unresectable diseases had an objective response (2 CR, 3 PR). The response rate in patients with metastatic disease was 23.0% (95% CI 14.4-31.6%). The median progression-free interval and overall survival time were 7 and 10 months, respectively. The most frequent side effect was alopecia (Gr I/II 71.4%). No treatment-related death occurred. Modified ELF is a relatively effective and tolerable combination regimen for advanced gastric cancer and can be safely administered to elderly patients and patients with systemic diseases.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalCancer Investigation
Issue number3
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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