TY - JOUR
T1 - Trauma and the default mode network
T2 - review and exploratory study
AU - Chan, Aldrich
AU - Harvey, Philip
AU - Hernandez-Cardenache, Rene
AU - Alperin, Noam
AU - Lee, Sang
AU - Hunt, Christopher
AU - Petersen, Nick
AU - Northoff, Georg
AU - Robertson, Nadine
AU - Ouyang, Jason
AU - Karasik, Ryan
AU - Williams, Kate
N1 - Publisher Copyright:
Copyright © 2024 Chan, Harvey, Hernandez-Cardenache, Alperin, Lee, Hunt, Petersen, Northoff, Robertson, Ouyang, Karasik and Williams.
PY - 2024
Y1 - 2024
N2 - While PTSD continues to be researched in great depth, less attention has been given to the continuum of traumatic responses that resides outside this diagnosis. This investigation begins with a literature review examining the spectrum of responses through the lens of the default mode network (DMN). To build upon this literature, a systematic exploratory study was incorporated, examining DMN-related neuropsychological functioning of 27 participants (16 trauma-exposed, and 11 non-trauma-exposed), with a subset (15 participants) completing neuroimaging. This study revealed that in comparison to the control group, the trauma-exposed group had reductions in their capacity for self-referential processing, social cognition, autobiographical recall, prospection, and increased mind-wandering. While correlations were encountered between cognitive findings and brain volume, comparative volumetric findings between trauma-exposed and non-t rauma exposed were insignificant. This suggests that the conservation of DMN structural integrity may play a role in resilience, supporting the existing theory that reduced hippocampal volume may be a pre-existing vulnerability to PTSD rather than a consequence and that reductions in DMN related cognition are functionally mediated.
AB - While PTSD continues to be researched in great depth, less attention has been given to the continuum of traumatic responses that resides outside this diagnosis. This investigation begins with a literature review examining the spectrum of responses through the lens of the default mode network (DMN). To build upon this literature, a systematic exploratory study was incorporated, examining DMN-related neuropsychological functioning of 27 participants (16 trauma-exposed, and 11 non-trauma-exposed), with a subset (15 participants) completing neuroimaging. This study revealed that in comparison to the control group, the trauma-exposed group had reductions in their capacity for self-referential processing, social cognition, autobiographical recall, prospection, and increased mind-wandering. While correlations were encountered between cognitive findings and brain volume, comparative volumetric findings between trauma-exposed and non-t rauma exposed were insignificant. This suggests that the conservation of DMN structural integrity may play a role in resilience, supporting the existing theory that reduced hippocampal volume may be a pre-existing vulnerability to PTSD rather than a consequence and that reductions in DMN related cognition are functionally mediated.
KW - default mode network
KW - neuropsychology
KW - non-trauma-exposed
KW - PTSD
KW - resilience
KW - review
KW - trauma
KW - trauma-exposed
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U2 - 10.3389/fnbeh.2024.1499408
DO - 10.3389/fnbeh.2024.1499408
M3 - Article
AN - SCOPUS:85213946695
SN - 1662-5153
VL - 18
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
M1 - 1499408
ER -