Transplantation of related histocompatible marrow and peripheral blood stem cells in a patient with severe combined immunodeficiency and disseminated BCG infection

Giun Yi Hung, Tzeon Jye Chiou, Ching Yuang Lin, Liang Tsai Hsiao, Po Min Chen, Betau Hwang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We report the results of allogeneic bone marrow transplantation (BMT) in a 15-month-old boy with severe combined immunodeficiency (SCID) complicated by disseminated Bacillus Calmette-Guerin (BCG) infection. Slow immunological recovery after BMT is considered to be associated with prolonged BCG infection. After one booster dose of allogeneic peripheral blood stem cell transplantation (PBSCT), there was still little improvement in immune reconstitution. The patient finally expired because of failure to achieve a functioning immune system after BMT and septic shock.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalJournal of the Chinese Medical Association
Volume66
Issue number1
Publication statusPublished - Jan 2003
Externally publishedYes

Keywords

  • BCG infection
  • Bone marrow transplantation
  • Peripheral blood stem cell transplantation
  • Severe combined immunodeficiency

ASJC Scopus subject areas

  • General Medicine

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