Transplantation of fetal kidney cells: Neuroprotection and neuroregeneration

Yung-Hsiao Chiang; C. V. Borlongan; F. C. Zhou; B. J. Hoffer; Yun Wang

doi:10.3727/000000005783983304

Transplantation of fetal kidney cells: Neuroprotection and neuroregeneration

Yung-Hsiao Chiang, C. V. Borlongan, F. C. Zhou, B. J. Hoffer, Yun Wang

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Various trophic factors in the transforming growth factor-β (TGF-β) superfamily have been reported to have neuroprotective and neuroregenerative effects. Intracerebral administration of glial cell line-derived neurotrophic factor (GDNF) or bone morphogenetic proteins (BMPs), both members of the TGF-β family, reduce ischemia- or 6-hydroxydopamine (6-OHDA)-induced injury in adult rat brain. Because BMPs and GDNF are highly expressed in fetal kidney cells, transplantation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against neuronal injury induced by ischemia, neurotoxins, or reactive oxygen species. In this review, we discuss preclinical evidence for the efficacy of fetal kidney cell transplantation in neuroprotection and regeneration models.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Cell Transplantation
Volume	14
Issue number	1
DOIs	https://doi.org/10.3727/000000005783983304
Publication status	Published - 2005
Externally published	Yes

Keywords

Fetal kidney
Parkinson's disease
Stroke

ASJC Scopus subject areas

Transplantation
Biomedical Engineering
Cell Biology

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10.3727/000000005783983304

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T1 - Transplantation of fetal kidney cells

T2 - Neuroprotection and neuroregeneration

AU - Chiang, Yung-Hsiao

AU - Borlongan, C. V.

AU - Zhou, F. C.

AU - Hoffer, B. J.

AU - Wang, Yun

PY - 2005

Y1 - 2005

N2 - Various trophic factors in the transforming growth factor-β (TGF-β) superfamily have been reported to have neuroprotective and neuroregenerative effects. Intracerebral administration of glial cell line-derived neurotrophic factor (GDNF) or bone morphogenetic proteins (BMPs), both members of the TGF-β family, reduce ischemia- or 6-hydroxydopamine (6-OHDA)-induced injury in adult rat brain. Because BMPs and GDNF are highly expressed in fetal kidney cells, transplantation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against neuronal injury induced by ischemia, neurotoxins, or reactive oxygen species. In this review, we discuss preclinical evidence for the efficacy of fetal kidney cell transplantation in neuroprotection and regeneration models.

AB - Various trophic factors in the transforming growth factor-β (TGF-β) superfamily have been reported to have neuroprotective and neuroregenerative effects. Intracerebral administration of glial cell line-derived neurotrophic factor (GDNF) or bone morphogenetic proteins (BMPs), both members of the TGF-β family, reduce ischemia- or 6-hydroxydopamine (6-OHDA)-induced injury in adult rat brain. Because BMPs and GDNF are highly expressed in fetal kidney cells, transplantation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against neuronal injury induced by ischemia, neurotoxins, or reactive oxygen species. In this review, we discuss preclinical evidence for the efficacy of fetal kidney cell transplantation in neuroprotection and regeneration models.

KW - Fetal kidney

KW - Parkinson's disease

KW - Stroke

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Transplantation of fetal kidney cells: Neuroprotection and neuroregeneration

Abstract

Keywords

ASJC Scopus subject areas

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